Journal of Oral Medicine and Pain

Korean Academy of Orofacial Pain and Oral Medicine (대한안면통증구강내과학회)
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Titanium Ions Released from Oral Casting Alloys May Contribute to the Symptom of Burning Mouth Syndrome

  • Park, Yang Mi (Department of Oral Medicine, School of Dentistry, Pusan National University, Dental Research Institute, Institute of Translational Dental Sciences) ;
  • Kim, Kyung-Hee (Department of Oral Medicine, Busan Paik Hospital, Inje University College of Medicine) ;
  • Lee, Sunhee (Department of Oral Medicine, School of Dentistry, Pusan National University, Dental Research Institute, Institute of Translational Dental Sciences) ;
  • Jeon, Hye-Mi (Dental Clinic Center, Pusan National University Hospital) ;
  • Heo, Jun-Young (Department of Oral Medicine, School of Dentistry, Pusan National University, Dental Research Institute, Institute of Translational Dental Sciences) ;
  • Ahn, Yong-Woo (Department of Oral Medicine, School of Dentistry, Pusan National University, Dental Research Institute, Institute of Translational Dental Sciences) ;
  • Ok, Soo-Min (Department of Oral Medicine, School of Dentistry, Pusan National University, Dental Research Institute, Institute of Translational Dental Sciences) ;
  • Jeong, Sung-Hee (Department of Oral Medicine, School of Dentistry, Pusan National University, Dental Research Institute, Institute of Translational Dental Sciences)
  • Received : 2017.10.31
  • Accepted : 2017.11.27
  • Published : 2017.12.30
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Abstract

Purpose: Many metal ions released from dental casting alloys have been reported to influence the intraoral symptoms of oral lichen planus (OLP) and burning mouth syndrome (BMS). The aim of this study was to investigate the relationship between salivary metal ion levels and the prosthetic duration as well as to evaluate the time-dependent morbid effects of metal ions in OLP and BMS patients. Methods: Three study groups consist of the following subjects respectively: 17 OLP patients, 12 BMS patients, and 12 patients without oral symptoms. The salivary concentrations of 13 metal ions (copper, cobalt, zinc, chromium, nickel, aluminum, silver, iron, titanium [Ti], platinum, tin, palladium, and gold) were measured by Laser Ablation Microprobe Inductively coupled Plasma Mass Spectrometry. Results: The Ti ions had statistically significant differences among the groups with a prosthetic duration of less than 5 years. There were no significant differences between all ion levels among the groups wearing dental cast alloys for over 5 years. In the BMS group, the level of Ti ions in patients with prosthetic restorations less than 5 years old were significantly high (p<0.05). Conclusions: In the BMS group, 3-60 months during which salivary Ti levels were higher were matched with the duration of burning symptoms ($15.6{\pm}17.1months$). Furthermore, Ti ions were statistically high in the oral cavity of BMS patients fitted with dental casting alloys for 5 years. These results suggest that Ti ions released from dental implants and oral prostheses could attribute to burning sensation of BMS.

Keywords

References

  1. Baricevic M, Mravak-Stipetic M, Stanimirovic A, et al. Salivary concentrations of nickel and chromium in patients with burning mouth syndrome. Acta Dermatovenerol Croat 2011;19:2-5.
  2. Garhammer P, Schmalz G, Hiller KA, Reitinger T. Metal content of biopsies adjacent to dental cast alloys. Clin Oral Investig 2003;7:92-97. https://doi.org/10.1007/s00784-003-0204-9
  3. Geurtsen W. Biocompatibility of dental casting alloys. Crit Rev Oral Biol Med 2002;13:71-84. https://doi.org/10.1177/154411130201300108
  4. Chainani-Wu N, Silverman S Jr, Lozada-Nur F, Mayer P, Watson JJ. Oral lichen planus: patient profile, disease progression and treatment responses. J Am Dent Assoc 2001;132:901-909. https://doi.org/10.14219/jada.archive.2001.0302
  5. Roopashree MR, Gondhalekar RV, Shashikanth MC, George J, Thippeswamy SH, Shukla A. Pathogenesis of oral lichen planus--a review. J Oral Pathol Med 2010;39:729-734. https://doi.org/10.1111/j.1600-0714.2010.00946.x
  6. Yiannias JA, el-Azhary RA, Hand JH, Pakzad SY, Rogers RS 3rd. Relevant contact sensitivities in patients with the diagnosis of oral lichen planus. J Am Acad Dermatol 2000;42:177-182. https://doi.org/10.1016/S0190-9622(00)90123-3
  7. Athavale PN, Shum KW, Yeoman CM, Gawkrodger DJ. Oral lichenoid lesions and contact allergy to dental mercury and gold. Contact Dermatitis 2003;49:264-265. https://doi.org/10.1111/j.0105-1873.2003.0225g.x
  8. Ditrichova D, Kapralova S, Tichy M, et al. Oral lichenoid lesions and allergy to dental materials. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2007;151:333-339. https://doi.org/10.5507/bp.2007.057
  9. Gawkrodger DJ. Investigation of reactions to dental materials. Br J Dermatol 2005;153:479-485. https://doi.org/10.1111/j.1365-2133.2005.06821.x
  10. Laeijendecker R, Dekker SK, Burger PM, Mulder PG, Van Joost T, Neumann MH. Oral lichen planus and allergy to dental amalgam restorations. Arch Dermatol 2004;140:1434-1438.
  11. Vucicevic-Boras V, Topic B, Zadro R, Stavljenic-Rukavina A. Quantity of salivary immunoglobulin A, lysozyme and magnesium in patients with burning mouth syndrome and xerostomia. Acta Stomat Croat 2001;35:211-214.
  12. Lopez-Jornet P, Juan H, Alvaro PF. Mineral and trace element analysis of saliva from patients with BMS: a cross-sectional prospective controlled clinical study. J Oral Pathol Med 2014;43:111-116. https://doi.org/10.1111/jop.12105
  13. Scala A, Checchi L, Montevecchi M, Marini I, Giamberardino MA. Update on burning mouth syndrome: overview and patient management. Crit Rev Oral Biol Med 2003;14:275-291. https://doi.org/10.1177/154411130301400405
  14. Pekiner FN, Gumru B, Demirel GY, Ozbayrak S. Burning mouth syndrome and saliva: detection of salivary trace elements and cytokines. J Oral Pathol Med 2009;38:269-275. https://doi.org/10.1111/j.1600-0714.2008.00734.x
  15. Cho GS, Han MW, Lee B, et al. Zinc deficiency may be a cause of burning mouth syndrome as zinc replacement therapy has therapeutic effects. J Oral Pathol Med 2010;39:722-727. https://doi.org/10.1111/j.1600-0714.2010.00914.x
  16. Maragou P, Ivanyi L. Serum zinc levels in patients with burning mouth syndrome. Oral Surg Oral Med Oral Pathol 1991;71:447-450. https://doi.org/10.1016/0030-4220(91)90427-E
  17. Garhammer P, Schmalz G, Hiller KA, Reitinger T, Stolz W. Patients with local adverse effects from dental alloys: frequency, complaints, symptoms, allergy. Clin Oral Investig 2001;5:240-249. https://doi.org/10.1007/s007840100127
  18. Lee JJ, Song KY, Ahn SG, Choi JY, Seo JM, Park JM. Evaluation of effect of galvanic corrosion between nickel-chromium metal and titanium on ion release and cell toxicity. J Adv Prosthodont 2015;7:172-177. https://doi.org/10.4047/jap.2015.7.2.172
  19. Wataha JC. Biocompatibility of dental casting alloys: a review. J Prosthet Dent 2000;83:223-234. https://doi.org/10.1016/S0022-3913(00)80016-5
  20. Wataha JC, Hanks CT, Craig RG. In vitro synergistic, antagonistic, and duration of exposure effects of metal cations on eukaryotic cells. J Biomed Mater Res 1992;26:1297-1309. https://doi.org/10.1002/jbm.820261004
  21. van der Meij EH, van der Waal I. Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications. J Oral Pathol Med 2003;32:507-512. https://doi.org/10.1034/j.1600-0714.2003.00125.x
  22. Kim HI, Kim YY, Chang JY, Ko JY, Kho HS. Salivary cortisol, $17{\beta}$-estradiol, progesterone, dehydroepiandrosterone, and ${\alpha}$-amylase in patients with burning mouth syndrome. Oral Dis 2012;18:613-620. https://doi.org/10.1111/j.1601-0825.2012.01937.x
  23. Chaturvedi T. Allergy related to dental implant and its clinical significance. Clin Cosmet Investig Dent 2013;5:57-61.
  24. Chaturvedi TP. An overview of the corrosion aspect of dental implants (titanium and its alloys). Indian J Dent Res 2009;20:91-98. https://doi.org/10.4103/0970-9290.49068
  25. Elshahawy W, Watanabe I, Koike M. Elemental ion release from four different fixed prosthodontic materials. Dent Mater 2009;25:976-981. https://doi.org/10.1016/j.dental.2009.02.004
  26. Mutlu-Sagesen L, Ergun G, Karabulut E. Ion release from metal-ceramic alloys in three different media. Dent Mater J 2011;30:598-610. https://doi.org/10.4012/dmj.2011-031
  27. Tamam E, Turkyilmaz I. Effects of pH and elevated glucose levels on the electrochemical behavior of dental implants. J Oral Implantol 2014;40:153-159. https://doi.org/10.1563/AAID-JOI-D-11-00083
  28. Schmalz G, Garhammer P. Biological interactions of dental cast alloys with oral tissues. Dent Mater 2002;18:396-406. https://doi.org/10.1016/S0109-5641(01)00063-X
  29. Kratzenstein B, Sauer KH, Weber H. In-vivo corrosion phenomena of cast restorations and their interactions with the oral cavity. Dtsch Zahnarztl Z 1988;43:343-348.
  30. Marcusson JA. Contact allergies to nickel sulfate, gold sodium thiosulfate and palladium chloride in patients claiming sideeffects from dental alloy components. Contact Dermatitis 1996;34:320-323. https://doi.org/10.1111/j.1600-0536.1996.tb02215.x
  31. Sperl K. Risikominimierung dentaler Legierungen. Rundschreiben der Interessengemeinschaft der Zahnmetallgeschadigten eV vom Dezember: Zahnmetallgeschadigten e.V. vom; 1995.
  32. Wirz J, Jager K, Schmidli F. Clinical corrosion. Effect of fissures on an incompatible nonprecious-metal crown alloy. Schweiz Monatsschr Zahnmed 1987;97:1151-1158.
  33. Frisken KW, Dandie GW, Lugowski S, Jordan G. A study of titanium release into body organs following the insertion of single threaded screw implants into the mandibles of sheep. Aust Dent J 2002;47:214-217. https://doi.org/10.1111/j.1834-7819.2002.tb00331.x
  34. Goutam M, Giriyapura C, Mishra SK, Gupta S. Titanium allergy: a literature review. Indian J Dermatol 2014;59:630.
  35. Sicilia A, Cuesta S, Coma G, et al. Titanium allergy in dental implant patients: a clinical study on 1500 consecutive patients. Clin Oral Implants Res 2008;19:823-835. https://doi.org/10.1111/j.1600-0501.2008.01544.x
  36. Smith DC, Lugowski S, McHugh A, Deporter D, Watson PA, Chipman M. Systemic metal ion levels in dental implant patients. Int J Oral Maxillofac Implants 1997;12:828-834.
  37. Takeuchi M, Abe Y, Yoshida Y, Nakayama Y, Okazaki M, Akagawa Y. Acid pretreatment of titanium implants. Biomaterials 2003;24:1821-1827. https://doi.org/10.1016/S0142-9612(02)00576-8
  38. Schliephake H, Lehmann H, Kunz U, Schmelzeisen R. Ultrastructural findings in soft tissues adjacent to titanium plates used in jaw fracture treatment. Int J Oral Maxillofac Surg 1993;22:20-25. https://doi.org/10.1016/S0901-5027(05)80350-9
  39. Weingart D, Steinemann S, Schilli W, et al. Titanium deposition in regional lymph nodes after insertion of titanium screw implants in maxillofacial region. Int J Oral Maxillofac Surg 1994;23:450-452. https://doi.org/10.1016/S0901-5027(05)80045-1
  40. Hicks DG, Judkins AR, Sickel JZ, Rosier RN, Puzas JE, O'Keefe RJ. Granular histiocytosis of pelvic lymph nodes following total hip arthroplasty. The presence of wear debris, cytokine production, and immunologically activated macrophages. J Bone Joint Surg Am 1996;78:482-496. https://doi.org/10.2106/00004623-199604000-00002
  41. Valentine-Thon E, Muller K, Guzzi G, Kreisel S, Ohnsorge P, Sandkamp M. LTT-MELISA is clinically relevant for detecting and monitoring metal sensitivity. Neuro Endocrinol Lett 2006;27 Suppl 1:17-24.
  42. Bilhan H, Bural C, Geckili O. Titanium hypersensitivity. A hidden threat for dental implant patients? N Y State Dent J 2013;79:38-43.
  43. Katou F, Andoh N, Motegi K, Nagura H. Immuno-inflammatory responses in the tissue adjacent to titanium miniplates used in the treatment of mandibular fractures. J Craniomaxillofac Surg 1996;24:155-162.
  44. Matthew IR, Frame JW. Ultrastructural analysis of metal particles released from stainless steel and titanium miniplate components in an animal model. J Oral Maxillofac Surg 1998;56:45-50. https://doi.org/10.1016/S0278-2391(98)90915-6
  45. Jacobs JJ, Skipor AK, Patterson LM, et al. Metal release in patients who have had a primary total hip arthroplasty. A prospective, controlled, longitudinal study. J Bone Joint Surg Am 1998;80:1447-1458. https://doi.org/10.2106/00004623-199810000-00006
  46. Jacobs JJ, Skipor AK, Black J, Urban Rm, Galante JO. Release and excretion of metal in patients who have a total hip-replacement component made of titanium-base alloy. J Bone Joint Surg Am 1991;73:1475-1486. https://doi.org/10.2106/00004623-199173100-00005
  47. Levine BR, Hsu AR, Skipor AK, et al. Ten-year outcome of serum metal ion levels after primary total hip arthroplasty: a concise follow-up of a previous report*. J Bone Joint Surg Am 2013;95:512-518. https://doi.org/10.2106/JBJS.L.00471
  48. Hirayama T, Koike M, Kurogi T, et al. Ion release from casts of commercially pure titanium in mixed solutions of organic acids contained in human saliva. Nihon Hotetsu Shika Gakkai Zasshi 2008;52:501-506. https://doi.org/10.2186/jjps.52.501
  49. Maruthamuthu S, Rajasekar A, Sathiyanarayanan S, Muthukumar N, Palaniswamy N. Electrochemical behaviour of microbes on orthodontic wires. Curr Sci 2005;89:988-996.
  50. Rosalbino F, Delsante S, Borzone G, Scavino G. Influence of noble metals alloying additions on the corrosion behaviour of titanium in a fluoride-containing environment. J Mater Sci Mater Med 2012;23:1129-1137. https://doi.org/10.1007/s10856-012-4591-9