Korean Journal of Agricultural Science (농업과학연구)

Institute of Agricultural Science, CNU (충남대학교 농업과학연구소)
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Population genetic analysis of special purpose dogs: linkage disequilibrium and effective population size

  • Lee, Doo Ho (Division of Animal & dairy Science, College of Agriculture & Life Sciences, Chungnam National University) ;
  • Lee, Soo Hyun (Division of Animal & dairy Science, College of Agriculture & Life Sciences, Chungnam National University) ;
  • Kang, Ji Min (Division of Animal & dairy Science, College of Agriculture & Life Sciences, Chungnam National University) ;
  • Ju, Ho Young (Department of Defense Military Observer Corps) ;
  • Lee, Cheol Koo (Department of Biotechnology, Korea University) ;
  • Choi, Bong Hwan (Animal Genome & Bioinformatics Division, National Institute of Animal Science, RDA) ;
  • Lee, Seung Hwan (Division of Animal & dairy Science, College of Agriculture & Life Sciences, Chungnam National University)
  • Received : 2017.09.20
  • Accepted : 2017.12.14
  • Published : 2017.12.31
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Abstract

As exchanges between countries become more active, new threats such as drugs, illegal imports of food and medicines, and terrorism are present all over the world. From this, increased border security that protects people's safety is becoming a new issue. The activities of special purpose dogs that detect these threats in advance are becoming very important. One of the obstacles in securing superior individuals is musculoskeletal disorders which interfere with the work of special purpose dogs. In order to search for genes associated with these genetic disorders, we conducted genomic analysis using linkage disequilibrium information and investigated genetic characteristics to know heterozygosity and inbreeding status in the population. In this study, two breeds (Malinois, Shepherd) of army dogs and three breeds (Malinois, Shepherd, Retriever) from public databases were used for comparison. The 170K SNP marker panel was used for this study. In the principal component analysis, it was confirmed that clusters were formed for each breed. The number of effective populations differed for each cultivar, but this was due to the difference in numbers of individuals for each breed used for the analysis. The results of heterozygosity decay analysis showed that heterozygous alleles decreased with each generation. In the army dog group, if the population number is maintained properly, the frequency of allele genotype will not decrease significantly.

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References

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