Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Effect and Response of Skeletal Muscle Cells on Electrical Stimulation Condition

전기자극 조건에 따른 근육 세포에 미치는 영향과 반응

  • Seo, Hyung Woo (Dept. of Biomedical Engineering, Konyang University) ;
  • Shin, Hyun Young (Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST)) ;
  • Lee, Hyun-Ju (Dept. of Physical Therapy, Konyang University) ;
  • Tae, Ki-Sik (Dept. of Biomedical Engineering, Konyang University) ;
  • Kim, Minseok S. (Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST))
  • 서형우 (건양대학교 의공학부) ;
  • 신현영 (대구경북과학기술원 뉴바이올로지학과) ;
  • 이현주 (건양대학교 물리치료학과) ;
  • 태기식 (건양대학교 의공학부) ;
  • 김민석 (대구경북과학기술원 뉴바이올로지학과)
  • Received : 2017.11.16
  • Accepted : 2017.11.25
  • Published : 2017.12.31
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Abstract

Skeletal muscle function plays a very important role in quality of life. However, skeletal muscle causes functional decline under aging or some diseases. Exercise and muscle training are good solutions to delay sarcopenia, but there are limitations to those who are uncomfortable in exercise. For this reason, alternative interventions for muscle sarcopenia are required, and many studies proved the increase of skeletal muscle mass by electrical stimulation. In conventional studies, however, mouse skeletal muscle cells have been mostly used in experiments to identify electrical stimulation conditions while human derived cells have not been frequently utilized in these studies. Stimulation used for rehabilitation has been uniformly treated without the consideration of aging. In addition, many studies have been used with conventional petri dish usually requiring many numbers of cells, which is not appropriate for rare. Moreover, they are not usually condition uniformity of electrical field. In this study, we have developed an electrical stimulation device which consumes a small amount of cells and can form a uniform electrical field. With the system, we analyzed the skeletal muscle differentiation and Myotube thickness depending on the electrical stimulation condition.

Keywords

References

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