Journal of the Korea Academia-Industrial cooperation Society (한국산학기술학회논문지)

The Korea Academia-Industrial cooperation Society (한국산학기술학회)
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Development of depression diagnosis system using EEG signal

뇌파 측정 신호를 이용한 우울증 진단장치 개발

  • Kim, Kyu-Sung (Division of Biomedical Engineering, Eulji University) ;
  • Jung, Ju-Hyeon (Division of Biomedical Engineering, Eulji University) ;
  • Lee, Woo-Cheol (Division of Biomedical Engineering, Eulji University)
  • Received : 2017.10.18
  • Accepted : 2017.12.08
  • Published : 2017.12.31
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Abstract

In this study, a device was developed for diagnosing depression using EEG signals from July 2016 to June 2017. For normal people, the left alpha rhythm is more activated than the right alpha rhythm, but for the depressed patients, the right alpha rhythm is more activated than the left one. An analog circuit and digital low pass filter were used for noise removal and amplification of EEG, and the Hamming window function was applied to eliminate the signal leakage generated by the fast Fourier transform. To verify the validity of the developed diagnosis system, the EEG of 20 university students in the 3rd and 4th grade with an average age of 24 years was measured. Calculations of the relative value of the left and right alpha rhythm for the depression diagnosis revealed a minimum, maximum, and mean value of 66.7, 113.3, and 92.2, respectively. In addition, 7 out of 20 subjects were between 90 and 95, and those with a higher mean deviation of approximately 20 tended to have mild depression. These results can provide meaningful data for the development of depression treatment equipment by solving the left and right brain asymmetry problem, and it may be applied usefully to diagnose depression after clinical trials on a large number of depressed patients.

본 연구에서는 2016년 7월부터 2017년 6월까지 1년 동안 뇌파 측정 신호를 이용한 우울증 진단장치를 개발하였다. 정상인의 경우 좌측 알파파가 우측 알파파에 비해 활성화되는 양상을 보이고, 우울증 환자의 경우 반대로 우측 알파파가 더 활성화된다. 뇌파의 잡음제거와 증폭을 위해 아날로그 회로와 디지털 저역통과필터를 사용하였고, 고속 푸리에 변환을 실시할 때 발생하는 신호의 누수를 제거하기 위해 해밍 창 함수를 적용하였다. 개발한 진단장치의 유효성능을 확인하기 위해 평균연령 24세의 대학교 3, 4학년 학생 20명을 대상으로 뇌파 측정을 실시하였다. 우울증 판독을 하기 위해 좌, 우 알파파의 상대 값을 계산한 결과 최솟값은 66.7, 최댓값은 113.3의 값을 가졌으며, 평균값은 92.2이었다. 또한 20명 중 7명이 90~95 사이에 해당되었고, 우울 점수의 평균 편차가 20가량 높은 사람의 경우 경미한 우울증세의 경향을 보였다. 본 연구 결론을 향후 좌, 우 뇌 비대칭 해소를 통한 우울증 치료기 제작 시 유의미한 자료로 사용할 수 있으며 다수의 우울증 환자에 대한 임상실험이 이루어질 경우 실제적 우울증 진단에 유용하게 적용할 수 있다.

Keywords

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