Journal of Korean Medicine for Obesity Research (한방비만학회지)

The Society of Korean Medicine for obesity Research (한방비만학회)
권호 표지
DOI QR코드

DOI QR Code

A 8-Week, Randomized, Double-Blind, Placebo-Controlled Human Trial to Evaluate the Efficacy and Safety of Punica granatum L.·Actinidia chinensis Planch. Mixed Extract on Body Fat

석류·참다래 혼합추출물의 체지방 감소에 대한 유효성 및 안전성을 평가하기 위한 8주, 무작위 배정, 이중눈가림, 위약-대조 인체적용시험

  • Choi, Jin-Bong (Department of Oriental Rehabilitation, College of Oriental Medicine, Dongshin University) ;
  • Lee, Ji-Eun (Department of Oriental Rehabilitation, College of Oriental Medicine, Dongshin University) ;
  • Do, Yun-Kyoung (Researcher Clinical Trial Center, College of Oriental Medicine, Dongshin University)
  • 최진봉 (동신대학교 광주한방병원 한방재활의학과) ;
  • 이지은 (동신대학교 광주한방병원 한방재활의학과) ;
  • 도윤경 (동신대학교 광주한방병원 임상시험센터)
  • Received : 2017.11.04
  • Accepted : 2017.11.27
  • Published : 2017.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: This study was conducted to evaluate efficacy and safety of Punica granatum L. Actinidia chinensis Planch. mixed extract on body fat. Methods: Thirty women were recruited ($25kg/m^2{\leq}body$ mass index [BMI]${\leq}29.9kg/m^2$) ($19yr{\leq}age{\leq}38yr$) and randomized to receive Punica granatum L. Actinidia chinensis Planch. mixed extract or placebo for 8 weeks. During the test, they visited four times including screening. Body fat mass, body fat rate, anthropometric dimensions at waist and hip, waist-hip ratio, total cholesterol, triglyceride, low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein-cholesterol (HDL-C) were measured at screening and 8 weeks after screening. Adverse reaction were also checked each visit. Results: There were no significant differences in all index. But when divide experimental group by BMI index, age, and compliance, less than BMI $27kg/m^2$ group decreased body weight, body fat mass and more than BMI $27kg/m^2$ group also decreased body weight, body fat mass and waist circumference. Less than age 30 years group showed decline of waist circumference, fat free rate and T-cholesterol and more than age 30 years group showed decline of fat free mass. Group with compliance more than 95% was decreased BMI, fat free mass, and hip circumference. Conclusions: There was no significant efficacy as compared with placebo group, but as divide experimental group according to BMI index, age, compliance, mixed extract might be effective to reduce obesity index.

Keywords

References

  1. Brat GA. Office management of obestiy. Seoul: Hanmi. 2005 : 30.
  2. James WP. The epidemiology of obesity: the size of the problem. J Intern Med. 2008 ; 263 : 336-52. https://doi.org/10.1111/j.1365-2796.2008.01922.x
  3. Statistical Office. Obesity prevalence trend [Internet]. Daejeon: Statistical Office; 2016. Available from: http://kosis.kr/index/index.do.
  4. Park HS, Park CY, Oh SW, Yoo HJ. Prevalence of obesity and metabolic syndroms in Korea adults. Obes Rev. 2008 ; 9 : 104-7.
  5. Yanovski SZ. Overweight, obesity, and health risk: National Task Force on the Prevention and Treatment of Obesity. Arch Intern Med. 2000 ; 160 : 898-904. https://doi.org/10.1001/archinte.160.7.898
  6. National Institutes of Health. National Institutes of Health Clinical Guideline on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report. Obes Res. 1998 : 6(2) : 518-209.
  7. Kaukua J, Pekkarinen T, Sane T, Muttajoki P. Health-related quality of life in obese outpatients losing weight with very low energy diet and behaviour modification; a 2y follow up study. Int J Obes Related Metab Disorder. 2003 ; 27(10) : 1233-41. https://doi.org/10.1038/sj.ijo.0802379
  8. Kang JG, Park CY. Antiobesity Drugs: A review about their effects and safety. Diabetes Metab J. 2012 ; 36 : 13-25. https://doi.org/10.4093/dmj.2012.36.1.13
  9. Kim SH, Kim IH, Kang BH, Cha TY, Lee JY, Lee JH, et al. Analysis of extraction characteristics of phytoestrogen components from Punica granatum L. J Korean Soc Appl Bio Chem. 2005 ; 48 : 352-7.
  10. Schubert SY, Lansky EP, Neeman I. Antioxidant and eicosanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavonoids. J Ethnopharmacol. 1999 ; 66 : 11-7. https://doi.org/10.1016/S0378-8741(98)00222-0
  11. Seeram N, Lee R, Hardy M, Heber D. Rapid large scale purification of ellagitannins from pomergranate peel, a by product of the commercial juice industry. Separ Purif Technol. 2005 ; 41 : 49-55. https://doi.org/10.1016/j.seppur.2004.04.003
  12. Lee DH, Lee SC, Hwang YI. Processing properties of kiwifruit treated with protopectinase. J Kor Soc Food Sci Nutr. 2000 ; 29 : 401-6.
  13. Kim HS, Kim BY, Kim MH. Utility of post-mature kiwi fruit powder in bakery products. J Kor Soc Food Sci Nutr. 2003 ; 32 : 581-5. https://doi.org/10.3746/jkfn.2003.32.4.581
  14. Sugiyama S, Hirota A, Okada C, Yorita T, Sato K, Ohtsuki K. Effect of kiwifruit juice on beef collagen. J Nutr Sci Vitaminol. 2005 ; 51 : 27-33. https://doi.org/10.3177/jnsv.51.27
  15. Oh JH, Lee KE, Kim JM, Lee SC. Preparation and chracteristics of whelk internal organ Jeotgal with the addition of fruit juice. J Kor Soc Food Sci Nutr. 2001 ; 30 : 641.
  16. Park YS, Jung ST, Kang SG, Drzewiecki J, Namiesnik J, Haruenkit R, et al. 2006. In vitro stuides polyphenols, antioxidants and other dietary indices in kiwifruit (Actinidia deliciosa). Int J Food Sci Nutr. 1983 ; 57 : 107-22. https://doi.org/10.1080/09637480600658385
  17. Motohashi N, Shirataki Y, Kawase M, Tani S, Sakagami H, Satoh K, et al. Cancer prevention and therapy with kiwifruit in Chinese folklore medicine: a study of kiwifruit extracts. J Ethnopharmacol. 2002 ; 81 : 357-64. https://doi.org/10.1016/S0378-8741(02)00125-3
  18. Kim JH, Yang HK, Hong HJ, Kang WY, Kim DG, Kim SC, et al. Neuroprotective effects of Korean kiwifruit against t-BHP induced cell damage in PC12 cells. Korea Plant Res. 2010 ; 23(2) : 165.
  19. Grube B, Chong PW, Lau KZ, Orzechowski HD. A natural fiber complex reduces body weight in the overweight and obese: a double-blind, randomized, placebo-controlled study. Obesity. 2013 ; 21(1) : 58-64. https://doi.org/10.1002/oby.20244
  20. Kim HK, Kim JH. Comparison of awareness and practice on well-being life and related behaviors according to generations. Korean J Community Nutr. 2007 ; 12(4) : 426-39.
  21. KNHANES. Health behaviors and chronic disease statistics [Internet]. Cheongwon: KNHANES; [cited 2010]. Available from: http://knhanes.cdc.go.kr/knhanes/index.do.
  22. Kim SY. The relationship between obesity degree and psychological factors, diettary behaviors and health-related quality of life in adult women in their twentis in Seoul and Kyungin area. Korean J Food Nutr. 2013 ; 26(3) ; 535-46. https://doi.org/10.9799/ksfan.2013.26.3.535
  23. Lim MY. A study of usage dietary supplement and related factors in college student attending web class via internet Korea. Korean J Food Nutr. 2001 ; 34 : 946-55.
  24. Seol YH. Consumer perception yoward antiobesity functional foods by women employees in their thirties and forties residing in capital region of Korea. Master's thesis. Seoul: Chung-ang University. 2011 : 1.
  25. Jeon B, Jeong HW. The experimental effects of pomegranate on the cerebral blood flow and obesity in rats. Korean J Food Nutr. 2007 ; 20(2) ; 143-9.
  26. Shin SM. Management of overweight and obesity: review of the “2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults”. Korean J Med. 2014 ; 82(2) : 136-41.

Cited by

  1. 최근 10년간 한방비만학회지의 연구동향 분석: 2010-2019년 한방비만학회지 게재논문을 중심으로 vol.20, pp.2, 2017, https://doi.org/10.15429/jkomor.2020.20.2.149