한국자원식물학회지 (Korean Journal of Plant Resources)

  • 제30권6호
  • /
  • Pages.601-611
  • /
  • 2017
  • /
  • 1226-3591(pISSN)
  • /
  • 2287-8203(eISSN)
한국자원식물학회 (The Plant Resources Society of Korea)
권호 표지
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Effects of the Jinan Red Ginseng Extract Treatment on Poloxamer 407-induced Hyperlipidemia in Rabbits

  • Choi, Kyung-Min (Nakdonggang Institute of Biological Resources) ;
  • Lee, Jeong Ho (Sunchang Research Institute of Health and Longevity) ;
  • Adam, Gareeballah Osman (Department of Pharmacology, College of Veterinary Medicine, Chonbuk National University, Iksan Campus) ;
  • Kim, Shang-Jin (Department of Pharmacology, College of Veterinary Medicine, Chonbuk National University, Iksan Campus) ;
  • Kang, Hyung-Sub (Department of Pharmacology, College of Veterinary Medicine, Chonbuk National University, Iksan Campus) ;
  • Yang, Yeong-Seok (Division of Pharmaceutical Engineering, Woosuk University) ;
  • Kim, Gi-Beum (Korea Pickle Co., LTD.)
  • 투고 : 2017.08.09
  • 심사 : 2017.10.16
  • 발행 : 2017.12.31
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초록

Hyperlipidemia is an increase in one or more of the plasma lipids, including triglycerides, cholesterol. Ginseng has been used as a valuable tonic and for the treatment of various diseases. The objective of this study was to evaluate the effects of Jinan red ginseng (JRG) water extract on the blood and serum in rabbits with hyperlipidemia induced by poloxamer 407 when supplied in drinking water. JRG treatment was performed for 20 weeks. We evaluated the effects of the JRG treatment on diabetes through hematological and biochemical analysis before and after JRG treatment were performed. Our results indicate that LDL, total cholesterol, and triglycerides were significantly decreased compared prior JRG supply. CRE, BUN, CK and UA levels indicating renal functions are significantly reduced when compared to those prior to the JRG supply. In addition, AST, ALT, ALP, and LDH were significantly reduced indicating hepatoprotective effect. Blood electrolytes deteriorated in HL rabbits were improved when JRG supplied. In conclusion, Biochemical and hematological analysis demonstrate that the JRG is effective to alleviate the hyperlipidemia signs.

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참고문헌

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