Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Tyndallized Lactobacillus plantarum HY7712 Restores Whole-Body γ-Irradiation-Impaired Th Cell Differentiation in Mice

  • Jang, Se-Eun (College of Pharmacy, Kyung Hee University) ;
  • Ko, Da-Bin (College of Pharmacy, Kyung Hee University) ;
  • Ahn, Young-Tae (Korea Yakult Co., Ltd.) ;
  • Sim, Jae-Hun (Korea Yakult Co., Ltd.) ;
  • Kim, Cha Soon (Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd.) ;
  • Kim, Dong-Hyun (College of Pharmacy, Kyung Hee University)
  • Received : 2017.06.13
  • Accepted : 2017.09.16
  • Published : 2017.12.28
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Abstract

In the present study, we investigated the effect of tyndallized HY7712 (tHY7712) on the expression of Th cell specific transcription factors and cytokines in whole-body ${\gamma}$-irradiated mice. Oral administration of tHY7712 strongly recovered the ${\gamma}$-irradiation-suppressed expression of helper T (Th) cell- and regulatory T cell-related transcription factors and cytokines, such as T-bet, Foxp3, IFN-${\gamma}$, TNF-${\alpha}$, and IL-10, and suppressed Th2 cell-associated transcription factor and cytokine GATA3 and IL-5, respectively. Furthermore, compared with the control, tHY7712 treatment also restored ${\gamma}$-irradiation-impaired natural killer and cytotoxic T cell activities against YAC-1 tumor cells to 97.8% and 98.6%, respectively.

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