동의신경정신과학회지 (Journal of Oriental Neuropsychiatry)

  • 제28권4호
  • /
  • Pages.319-332
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  • 2017
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  • 1226-6396(pISSN)
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  • 2234-4942(eISSN)
대한한방신경정신과학회 (The Korean Society of Oriental Neuropsychiatry)
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불면장애에 대한 혈부축어탕의 체계적 문헌 고찰 및 메타분석 연구

Herbal Medicine (Hyeolbuchukeo-tang, Xuefu Zhuyu Decoction) for Insomnia Disorder: A Systematic Review and Meta-analysis of Randomized Controlled Trials

  • 김동희 (동의대학교 부속한방병원 한방신경정신과) ;
  • 이승환 (부산대학교 부속한방병원 한방신경정신과) ;
  • 임정화 (부산대학교 한의학전문대학원 한방신경정신과교실) ;
  • 김상호 (대구한의대학교 한의과대학 한방신경정신과교실) ;
  • 이상협 (동의대학교 한의과대학 원전학교실) ;
  • 김보경 (동의대학교 한의과대학 한방신경정신과교실)
  • Kim, Dong-Hee (Department of Oriental Neuropsychiatry, Dong-Eui University Korean Medical Hospital) ;
  • Lee, Seung-Hwan (Department of Oriental Neuropsychiatry, Pusan National University Korean Medical Hospital) ;
  • Lim, Jung-Hwa (Department of Oriental Neuropsychiatry, School of Korean Medicine, Pusan National University) ;
  • Kim, Sang-Ho (Department of Oriental Neuropsychiatry, School of Korean Medicine, Daegu Haany University) ;
  • Lee, Sang-Hyup (Department of Korean Medical Classics, School of Korean Medicine, Dong-Eui University) ;
  • Kim, Bo-Kyung (Department of Oriental Neuropsychiatry, School of Korean Medicine, Dong-Eui University)
  • 투고 : 2017.10.16
  • 심사 : 2017.12.18
  • 발행 : 2017.12.30
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초록

Objectives: The present study aimed to provide clinical evidence on the effect of herbal medicine, Hyeolbuchukeo-tang or Xuefu Zhuyu decoction for the treatment of primary insomnia using a systematic review and meta-analysis of randomized controlled trials (RCTs). Methods: This study included RCTs that verified the effects of Hyeolbuchukeo-tang or Xuefu Zhuyu decoction for the treatment of primary insomnia. Literature searches of English, Chinese and Korean databases were performed, and the selected literature was assessed for investigating the risk of bias. Results: The analysis included 10 RCTs. The Chinese Classification of Mental Disorders-3 was most frequently used to define the diagnostic criteria for Hyeolbuchukeo-tang or Xuefu Zhuyu decoction intervention in patients with primary insomnia. The effective rate was the most commonly used outcome measure. A meta-analysis revealed that the effective rate, the Pittsburgh Sleep Quality Index, and the Athens Insomnia Scale in the Modified Xuefu Zhuyu decoction (MXZD) group were higher compared to Western Medicine (WM) group (RR: 1.17, 95% Cl: 1.08 to 1.26, p<0.0001, $I^2$=0/MD: -1.29, 95% Cl: -2.09 to -0.49, p=0.002, $I^2$=0%/MD: -0.99, 95% Cl: -1.81 to -0.18, p=0.02, $I^2$=15%). The effective rate of the MXZD+WM group was significantly different compared to the WM group (RR: 1.28, 95% Cl: 1.11 to 1.47, p=0.0006, $I^2$=2%). The included RCTs were of relatively poor quality and had small sample sizes. Conclusions: Treatment with Hyeolbuchukeo-tang or Xuefu Zhuyu decoction was found to be effective in treating primary insomnia. However, the included RCTs were of relatively poor quality and had small sample sizes. It is hypothesized that this study could serve as a foundation for further clinical studies on the development of diagnosis and treatment methods for primary insomnia based on Korean medicine.

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