대한후두음성언어의학회지 (Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics)

  • 제28권2호
  • /
  • Pages.144-147
  • /
  • 2017
  • /
  • 2508-268X(pISSN)
  • /
  • 2508-5603(eISSN)
대한후두음성언어의학회 (The Korean Society of Laryngology, Phoniatrics and Logopedics. )
권호 표지

흡인성 화상을 입은 환자에서 관찰된 후두점막의 악성변화 1례

A Case of Malignant Transformation of Layngeal Mucosa after Inhalation Injury 25 Years Ago

  • 이재영 (경북대학교 의학전문대학원 칠곡경북대학교병원 이비인후과-두경부외과학교실) ;
  • 이길준 (경북대학교 의학전문대학원 칠곡경북대학교병원 이비인후과-두경부외과학교실) ;
  • 안동빈 (경북대학교 의학전문대학원 칠곡경북대학교병원 이비인후과-두경부외과학교실) ;
  • 손진호 (경북대학교 의학전문대학원 칠곡경북대학교병원 이비인후과-두경부외과학교실)
  • Lee, Jae Young (Department of Otorhinolaryngology-Head and Neck Surgery, Kyungpook National University School of Medicine, Kyungpook National University Chilgok Hospital) ;
  • Lee, GilJoon (Department of Otorhinolaryngology-Head and Neck Surgery, Kyungpook National University School of Medicine, Kyungpook National University Chilgok Hospital) ;
  • Ahn, Dongbin (Department of Otorhinolaryngology-Head and Neck Surgery, Kyungpook National University School of Medicine, Kyungpook National University Chilgok Hospital) ;
  • Sohn, Jin Ho (Department of Otorhinolaryngology-Head and Neck Surgery, Kyungpook National University School of Medicine, Kyungpook National University Chilgok Hospital)
  • 투고 : 2017.10.25
  • 심사 : 2017.11.25
  • 발행 : 2017.12.30
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초록

Laryngeal neoplasm is the second most common malignancy of the upper aerodigestive tract. About 85% to 95% of laryngeal malignancies are squamous cell carcinoma that arises from the epithelial lining of the larynx. The exact cause of laryngeal neoplasm is unknown, but certain risk factors can affect the chances of developing it. Chronic inflammation is a mutagen factor confirmed in the carcinogenesis of various tumor. Inhalation injuries cause histopathologic damage to laryngeal mucosa and inflammation change. This long term inflammation may leads to the development of dysplasia and malignant transformation. Recently, we experienced a case of malignant transformation of laryngeal mucosa after inhalation injury patient 25 years ago. Herein, we reported this rare case and review the relevant literature.

키워드

참고문헌

  1. Brady JS, Crippen MM, Filimonov A, Eloy JA, Baredes S, Park RCW. Laryngectomy and smoking: An analysis of postoperative risk. Laryngoscope 2017;127(10):2302-9. https://doi.org/10.1002/lary.26615
  2. Nair S, Datta S, Thiagarajan S, Chakrabarti S, Nair D, Chaturvedi P. Squamous cell carcinoma of the upper aerodigestive tract in exclusive smokers, chewers, and those with no habits. Indian J Cancer 2016;53(4):538-41. https://doi.org/10.4103/0019-509X.204759
  3. Ellis L, Coleman MP, Rachet B. The impact of life tables adjusted for smoking on the socio-economic difference in net survival for laryngeal and lung cancer. Br J Cancer 2014;111(1):195-202 https://doi.org/10.1038/bjc.2014.217
  4. Hsueh C, Tao L, Zhang M, Cao W, Gong H, Zhou J, et al. The prognostic value of preoperative neutrophils, platelets, lymphocytes, monocytes and calculated ratios in patients with laryngeal squamous cell cancer. Oncotarget 2017;8(36):60514-27.
  5. Galli J, Cammarota G, Volante M, De Corso E, Almadori G, Paludetti G. Laryngeal carcinoma and laryngo-pharyngeal reflux disease. Acta Otorhinolaryngol Ital 2006;26:260-3.
  6. Ames BN, Gold LS, Willett WC. The causes and prevention of cancer. Proc Nat Acad Sci 1995;92(12):5258-65. https://doi.org/10.1073/pnas.92.12.5258
  7. Kim YM, Cho JI, Im JH, Kim YJ, Lee CW, Lee MT. Laryngeal Inhalation Injury. The Journal of the Korean Society of Phoniatrics and Logotedics 2001;12(1):11-6.
  8. Chang JH, Kim IW, Park IS, Kim BG, Kim YB, Rho YS, et al. Histopathologic Changes of Tracheal Mucosa in Burned Patients with Inhalation Injury. Korean Journal of Otolaryngology-Head and Neck Surgery 2007;50(5):438-41.
  9. Park GY, Park JW, Jeong DH, Jeong SH. Prolonged airway and systemic inflammatory reaction after smoke inhalation. Chest 2003;123 (2):475-80. https://doi.org/10.1378/chest.123.2.475
  10. Treves N, Pack GT. Development of cancer in burn scars. Surg Gynecol Obstet 1930;512:749-82.
  11. Rakoff-Nahoum S. Why Cancer and Inflammation? Yale Journal of Biology and Medicine 2006;79:123-30.
  12. Lee SH, Shin MS, Kim HS, Park WS, Kim SY, Jang JJ, et al. Somatic Mutations of Fas (Apo-1/CD95) gene in cutaneous squamous cell carcinoma arising from a burn scar. J Invest Dermatol 2000;114:122-6. https://doi.org/10.1046/j.1523-1747.2000.00819.x