Journal of The Korean Society of Integrative Medicine (대한통합의학회지)

Korean Society of Integrative Medicine (대한통합의학회)
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Effect of Adjuvant Administration on Gastrocnemius Atrophy Induced by Ankle Joint Fixation in Rats

흰쥐 발목고정으로 유발된 비복근 위축에서 보조약물 투여가 미치는 효과

  • Kim, Bumhoi (Dept. of Dong-eui College of Korean Medicine) ;
  • Lee, Taesik (Dept. of Physical Therapy, Dong-eui Institute of Technology)
  • 김범회 (동의대학교 한의과대학 한의학과) ;
  • 이태식 (동의과학대학교 물리치료과)
  • Received : 2017.11.13
  • Accepted : 2017.12.11
  • Published : 2017.12.30
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Abstract

Purpose : In this study we tested the hypothesis that eucommia ulmoides (EU) extract would improve disuse-induced muscle atrophy following hindlimb immobilization. Method : The hindlimb immobilization was performed with casting tape to keep the left ankle joint in a fully extended position. The rats in EU treated group were orally administrated with eucommia ulmoides water extract. After 2 weeks of immobilization, all animals were sacrificed, and the whole gastrocnemius muscles were dissected from both legs. The morphology of right and left gastrocnemius muscles in both EU and control groups were assessed by hematoxylin and eosin staining. Results : Eucommia ulmoides extract represented the significant protective effects against the reductions of the gastrocnemius muscles weight and average cross section area to compared with Control group. Conclusion : Eucommia ulmoides has protective effects against immobilization induced muscle atrophy.

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References

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