Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Rickets caused by vitamin D deficiency in calves

송아지에서 비타민 D 결핍에 의한 구루병 증례 보고

  • Kim, Ji-Hyeon (Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency) ;
  • Lee, Kyunghyun (Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency) ;
  • Jung, Ji-Youl (Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency) ;
  • Yang, Siyeon (Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency) ;
  • Lee, Hyunkyoung (Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency) ;
  • So, ByungJae (Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency) ;
  • Choi, Eunjin (Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency)
  • 김지현 (농림축산검역본부 질병진단과) ;
  • 이경현 (농림축산검역본부 질병진단과) ;
  • 정지열 (농림축산검역본부 질병진단과) ;
  • 양시연 (농림축산검역본부 질병진단과) ;
  • 이현경 (농림축산검역본부 질병진단과) ;
  • 소병재 (농림축산검역본부 질병진단과) ;
  • 최은진 (농림축산검역본부 질병진단과)
  • Received : 2017.09.25
  • Accepted : 2017.11.04
  • Published : 2017.12.30
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Abstract

Six to seven-month-old 10 beef calves in 140-head beef cattle farm in Gimpo-si, Gyeonggi-do were suffered from ataxia and astasia. Two of them were submitted to Animal and Plant Quarantine Agency for diagnosis in July 9, 2015. At necropsy, the radius and tibia of both calves showed irregular thickening and hemorrhage of the physis in addition to hemorrhage and disruption of trabeculae in metaphysis. Histopathologically the physis showed irregular tongues of cartilage remaining the metaphysis. Disorganization, hemorrhage and fibrosis were observed in metaphyseal and epiphyseal bones. The serum 25-hydroxyvitamin $D_3$ ($D_3$) and calcium levels were lower than normal range. In addition, the serum $D_3$ levels in the other 9 calves of the same farm were lower than normal levels. Based on the pathological examination and serum chemistry measurements, we diagnosed this case as rickets caused by vitamin D deficiency in calves.

Keywords

References

  1. Azam N, Zhang MYH, Wang XM, Tenenhouse HS, Portale AA. 2003. Disordered regulation of renal 25-hydroxyvitamin D-$1{\alpha}$-hydroxylase gene expression by phosphorus in X-linked hypophosphatemic (Hyp) mice. Endocrinology 144: 3463-3468. https://doi.org/10.1210/en.2003-0255
  2. Bangoura B, Daugschies A. 2007. Influence of experimental Eimeria zuernii infection in calves on electrolyte concentrations, acid-base balance and blood gases. Parasitol Res 6: 1637-1645.
  3. Bernstein CN, Leslie WD. 2003. The pathophysiology of bone disease in gastrointestinal disease. Eur J Gastroenterol Hepatol 15: 857-864. https://doi.org/10.1097/00042737-200308000-00004
  4. Bikle DD. 2007. Vitamin D insufficiency/deficiency in gastrointestinal disorders. J Bone Miner Res 2: 50-54.
  5. Burild A, Lauridsen C, Faqir N, Sommer HM, Jakobsen J. 2016. Vitamin D3 and 25-hydroxyvitamin D3 in pork and their relationship to vitamin D status in pigs. J Nutr Sci 5: 1-6. https://doi.org/10.1017/jns.2015.35
  6. Deluca HF. 2005. Historical perspevtive. pp. 3-12. In: Vitamin D, Feld, D., Pike, J.W. and Glorieus, F.H(ed). 2nd ed. Elsevier Academic Press, Burlington MA, U.S.A.
  7. Dittmer KE, Thompson KG. 2011. Vitamin D metabolism and rickets in domestic animals: a review. Vet Pathol 48(2): 389-407. https://doi.org/10.1177/0300985810375240
  8. Geisen V, Weber K, Hartmann K. 2009. Vitamin D-dependent hereditary rickets type I in a cat. J Vet Intern Med 23: 196-199. https://doi.org/10.1111/j.1939-1676.2008.0220.x
  9. Godfrey DR, Anderson RM, Barber PJ, Hewison M. 2005. Vitamin D-dependent rickets type II in a cat. J Small Anim Pract 46: 440-444. https://doi.org/10.1111/j.1748-5827.2005.tb00343.x
  10. Grant Maxie M. 2016. Bones and joints. pp. 72-75. Jubb, Kennedy, and Palmer's Pathology of domestic animals. Volume 1. 6th ed. Elsevier. Missouri.
  11. Holick MF. 2003. Vitamin D: A millenium perspective. J Cell Biochem. 88(2): 296-307. https://doi.org/10.1002/jcb.10338
  12. Holick MF. 2006. Resurrection of vitamin D deficiency and rickets. J Clin invest. 116(8): 2062-2072. https://doi.org/10.1172/JCI29449
  13. Klein GL. 1999. Nutritional rickets and osteomalacia. pp. 315-319. In: Primer on the Metabolic bone disease and disorders of mineral metabolism, Fevus MJ(ed). 4th ed. Lippincott Williams & Wilkins, Philadelphia, PA.
  14. Lukasz K, Adam S. 2005. Parathyroid hormone level in blood of cows with different forms of clinical hypocalcaemia. Bull Vet Inst Pulawy 49: 129-132.
  15. Mccarthy EF, Frassica FJ. 1998. Metabolic bone diseases. pp. 75-103. In: Pathology of bone and joint disorders with clinical and radiographic correlation. WB Saunders company, Philadelphia, PA.
  16. Pugh DG, Baird AN. 2012. Diseases of the neurologic system. 2nd ed. Sheep and goat medicine. Elsevier. St. Louis, Mo.
  17. Saliba W, Elhaddad B. 2009. Secondary hyperparathyroidism: pathophysiology and treatment. J Am Board Fam Med 22(5): 574-581. https://doi.org/10.3122/jabfm.2009.05.090026
  18. Schmid A, Walther B. 2013. Natural vitamin D content in animals products. Adv Nutr 4(4): 453-462. https://doi.org/10.3945/an.113.003780
  19. Suda T, Ueno Y, Fujii K, Shinki T. 2003. Vitamin D and bone. J Cell Biochem 88: 259-266. https://doi.org/10.1002/jcb.10331
  20. Suzuki Y, Landowski CP, Hediger MA. 2008. Mechanisms and regulation of epithelial $Ca^{2+}$ absorption in health and disease. Annu Rev Physiol 70: 3.1-2.15.
  21. Terushkin V, Bender A, Psaty EL, Engelsen O, Wang SQ, Halpern AC. 2010. Estimated equivalency of vitamin D production from natural sun exposure versus oral vitamin D supplementation across seasons at two US latitudes. J Am Acad Dermatol 62(6): 926-929.
  22. Van Saun RJ. 2004. Vitamin D-responsive rickets in neonatal lambs. Can Vet J 45:841-844.
  23. 이방환, 강정부, 권오덕 외 15명 한국수의내과학 교수협의회. 2004. 영양장애성 질병. pp. 774-782. 대동물내과학. 1판. 교육문화원, 서울.