Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Cytotoxicity and Structure Activity Relationship of Dammarane-Type Triterpenoids from the Bark of Aglaia elliptica against P-388 Murine Leukemia Cells

  • Hidayat, Ace Tatang (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran) ;
  • Farabi, Kindi (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran) ;
  • Harneti, Desi (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran) ;
  • Maharani, Rani (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran) ;
  • Darwati, Darwati (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran) ;
  • Nurlelasari, Nurlelasari (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran) ;
  • Mayanti, Tri (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran) ;
  • Setiawan, Arlette Suzy (Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Padjadjaran) ;
  • Supratman, Unang (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran) ;
  • Shiono, Yoshihito (Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University)
  • Received : 2017.09.15
  • Accepted : 2017.10.03
  • Published : 2017.12.29
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Abstract

Six dammarane-type triterpenoids, dammar-24-en-$3{\beta}$-ol (1), $3{\beta}$-epicabraleahydroxy lactone (2), (E)-25-hydroperoxydammar-23-en-$3{\beta}$,20-diol (3), dammar-24-en-$3{\beta}$,20-diol (4), $3{\beta}$-acetyl-20S,24S-epoxy-25-hydroxydammarane (5), and $3{\beta}$-epiocotillol (6) were isolated from the methanolic extract of the bark of Aglaia elliptica. The chemical structure were identified on the basis of spectroscopic evidence and by comparison with those spectra previously reported. Compounds 1 - 6 were isolated first time from this plant. Compounds 1 - 6, along with a known synthetic analog, cabraleone (7) were evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those compounds $3{\beta}$-acetyl-20S,24S-epoxy-25-hydroxydammarane (5) showed strongest cytotoxic activity with $IC_{50}$ value of $8.02{\pm}0.06{\mu}M$.

Keywords

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