Anti-inflammatory and anti-atopic effects of corn silk (Zea mays L.) ethanol extracts

옥수수수염 알코올 추출물의 항염 및 항아토피 효과

  • Kim, Hyun Young (Crop Foundation Division, National Institute of Crop Science, Rural Development Administration) ;
  • Lee, Mi-Ja (Crop Foundation Division, National Institute of Crop Science, Rural Development Administration) ;
  • Seo, Woo Duck (Crop Foundation Division, National Institute of Crop Science, Rural Development Administration) ;
  • Choi, Sik-Won (Crop Foundation Division, National Institute of Crop Science, Rural Development Administration) ;
  • Kim, Sun Lim (Department of Central Area Crop Science, National Institute of Crop Science, Rural Development Administration) ;
  • Jung, Gun-Ho (Department of Central Area Crop Science, National Institute of Crop Science, Rural Development Administration) ;
  • Kang, Hyeon Jung (Crop Foundation Division, National Institute of Crop Science, Rural Development Administration)
  • 김현영 (농촌진흥청 국립식량과학원 작물기초기반과) ;
  • 이미자 (농촌진흥청 국립식량과학원 작물기초기반과) ;
  • 서우덕 (농촌진흥청 국립식량과학원 작물기초기반과) ;
  • 최식원 (농촌진흥청 국립식량과학원 작물기초기반과) ;
  • 김선림 (농촌진흥청 국립식량과학원 중부작물부) ;
  • 정건호 (농촌진흥청 국립식량과학원 중부작물부) ;
  • 강현중 (농촌진흥청 국립식량과학원 작물기초기반과)
  • Received : 2017.07.14
  • Accepted : 2017.09.13
  • Published : 2017.12.31


This study evaluates the ability of corn silk (Zea mays L.) extract to function as a natural anti-inflammatory and anti-atopic therapeutic agent. The anti-inflammatory effects of corn silk were evaluated by measuring the inhibitory activities of nitric oxide (NO) and production of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$. Anti-atopic effects were assessed by measuring the repression of thymus and activation-regulated chemokine (TARC). These results indicated that NICS-1 (corn silk ethanol extract) and NICS-3 (high maysin corn silk ethanol extract) functioned as anti-inflammatory agents by down-regulating LPS-induced NO and TNF-${\alpha}$. Additionally, two extracts showed weak repression of TARC expression levels in tumor necrosis factor TNF-${\alpha}$ plus IFN-${\gamma}$ induced HaCaT cells, respectively. These results suggest that corn silk extracts have anti-inflammatory and anti-atopic activities, and thus have the potential to reduce and alleviate the symptoms associated with atopic dermatitis.

옥수수수염 추출물에서 분리한 NICS-1 및 NICS-3이 가지고 있는 항염 및 항아토피 활성을 알아보기 위하여 각각 RAW 264.7 및 HaCaT 세포를 이용하여 NO 및 TNF-${\alpha}$ 생성 저해능과 TARC 생성량 정도를 측정하였다. 그 결과 항염활성의 경우 NICS-1 및 NICS-3 두 추출물 모두 NO 및 TNF-${\alpha}$ 생성량이 농도의존적으로 크게 감소하였으며, NICS-3이 더 높은 활성을 나타냈다. 또한 항아토피 활성의 경우도 두 추출물 모두 TARC 생성이 대조구에 비하여 크게 감소하였으며 NICS-3 보다 NICS-1이 더 우수한 활성을 나타냈다.



Grant : 옥수수수염 함유 메이신 다량 분리법 개발 및 산업소재화를 위한 기초특성연구

Supported by : 농촌진흥청


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