대한치과의사협회지 (The Journal of the Korean dental association)

  • 제54권3호
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  • Pages.206-216
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  • 2016
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  • 0376-4672(pISSN)
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  • 2713-7961(eISSN)
대한치과의사협회 (The Korean Dental Association)
권호 표지

The antibacterial effect of xanthorrhizol as an endodontic irrigant on Enterococcus faecalis

  • Yue, Wonyoung (Microscope Center, Department of Conservative Dentistry and Oral Science Research Center, College of Dentistry, Yonsei University) ;
  • Song, Minju (Division of Constitutive & Regenerative Sciences Section of Restorative Dentistry, UCLA School of Dentistry) ;
  • Kang, Si-Mook (Department of Preventive Dentistry and Public Oral Health, BK 21 Plus Project, College of Dentistry, Yonsei University) ;
  • Kim, Baek-il (Department of Preventive Dentistry and Public Oral Health, BK 21 Plus Project, College of Dentistry, Yonsei University) ;
  • Yoon, Tai-Cheol (Deptartment of Conservative Dentistry and Endodontics, National Health Insurance Service Ilsan Hospital) ;
  • Kim, Euiseong (Microscope Center, Department of Conservative Dentistry and Oral Science Research Center, College of Dentistry, Yonsei University)
  • 투고 : 2015.11.19
  • 심사 : 2016.01.15
  • 발행 : 2016.03.01
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초록

Objectives The aim of this study was to evaluate the antibacterial effect of xanthorrhizol (XTZ) on E. faecalis, compared with 2% chlorhexidine (CHX). Materials and Methods Normal physiological state (NS), starvation state (SS), and alkalization state (AS) of E. faecalis were used. A solution containing 1% XTZ in 30% ethanol, 1% dimethyl sulfoxide (DMSO), and 100 mg/ml sodium methyl cocoyl taurate was used and is referred to as Xan in this study. To determine the minimal bactericidal concentration (MBC) of Xan and CHX, $500{\mu}l$ of E. faecalis (NS and two stress states) was added to a microtube containing $500{\mu}l$ of serial 2-fold dilutions of 1% Xan and 2% CHX (1:2-1:128). The MBC of each antimicrobial was determined by the plate count method. Results The antibacterial effect of Xan was more effective on E. faecalis in AS than in the other states (NS, SS) at 0.125% Xan and 0.03325% Xan (P<0.05). In contrast, the antibacterial effect of CHX was more effective against E. faecalis in SS than the other states (NS, AS) at 0.0625% CHX (P<0.05). In SS, the antibacterial effect of CHX was more effective than that of Xan at 0.125% and 0.0625% (P<0.05). However, in AS, the antibacterial effect of Xan was more effective than that of CHX at 0.0625% and 0.03325% (P<0.05). Conclusions In endodontic retreatment cases in which it is important to effectively remove E. faecalis from the infected root canal, Xan may be more suitable when combined with NaOCl than CHX.

키워드

과제정보

연구 과제 주관 기관 : Yonsei University College of Dentistry

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