Childhood Kidney Diseases

Korean Society of Pediatric Nephrology (대한소아신장학회)
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Nonobstructive Bilateral Hydronephrosis & Hydroureter from Nephrogenic Diabetes Insipidus with a Novel Mutation of AQP2 Gene (p.A123G)

  • Song, Ki Sup (Department of Pediatrics, Yonsei University Wonju College of Medicine) ;
  • Soo, Jeon Ihn (Department of Pediatrics, Yonsei University Wonju College of Medicine) ;
  • Namgoong, Mee Kyung (Department of Pediatrics, Yonsei University Wonju College of Medicine)
  • Received : 2016.08.26
  • Accepted : 2016.10.04
  • Published : 2016.10.30
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Abstract

Nephrogenic diabetes insipidus (NDI) can cause nonobstructive hydronephrosis. Congenital NDI (CNDI) is caused by a genetic mutation. This case report presents a 12-year-old girl who was incidentally diagnosed with nonobstructive hydronephrosis due to NDI caused by AQP2 gene mutation after being evaluated for microscopic hematuria found on routine health examination at school. The patient's medical and family history was unremarkable, and she complained of nocturia only at the time of the clinic visit. Bilateral hydronephrosis on abdominal ultrasonography prompted a water deprivation test, leading to diagnosis of NDI. Genetic study confirmed p.Asn (AAC)123Ser (AGC) in exon 2 of the AQP2 gene. Polyuria and hydronephrosis improved following arginine-vasopressin therapy. CNDI responsive to treatment should be considered as a possible cause of nonobstructive hydroureter.

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References

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