Toxicological Research

  • 제32권4호
  • /
  • Pages.327-335
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  • 2016
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  • 1976-8257(pISSN)
  • /
  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
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Reproductive and Developmental Toxicity Screening Test of Ethyl Hydrogen Adipate in Rats

  • Nam, Chunja (Biotoxtech Co., Ltd.) ;
  • Hwang, Jae-Sik (Biotoxtech Co., Ltd.) ;
  • Han, Kyoung-Goo (Biotoxtech Co., Ltd.) ;
  • Jo, Eunhye (Environmental Health Research Department, National Institute of Environmental Research) ;
  • Yoo, Sun-kyoung (Environmental Health Research Department, National Institute of Environmental Research) ;
  • Eom, Ig-Chun (Environmental Health Research Department, National Institute of Environmental Research) ;
  • Kang, Jong-Koo (Department of Laboratory Animal Medicine, College of Veterinary Medicine, Chungbuk National University)
  • 투고 : 2015.11.18
  • 심사 : 2016.08.30
  • 발행 : 2016.10.15
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초록

This study aimed to evaluate the potential toxicity and safety of ethyl hydrogen adipate (EHA) by determining its effect on the reproductive function and development of Sprague-Dawley (SD) rats at dose levels of 0 (control), 200, 400, and 800 mg/kg/day. One male and five females of the 800 mg/kg/day died. Body weight loss was observed in the males of the 800 mg/kg/day and in females of the 400 and 800 mg/kg/day. In addition, mating indices decreased and pre-implantation loss rates increased in parental animals of the 400 and 800 mg/kg/day. The gestation index decreased in the male and female rats of the 800 mg/kg/day. Moreover, the body weight of the pups from the 800 mg/kg/day group decreased on post-parturition day 4. These results indicated that the no-observed-adverse-effect level of EHA for parental males and females was 400 mg/kg/day and 200 mg/kg/day, respectively, and that for pups was 400 mg/kg/day.

키워드

참고문헌

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피인용 문헌

  1. Tocotrienol-rich fraction supplementation prevents foetal loss in females mated with corticosterone-treated male Sprague-Dawley rats pp.03034569, 2018, https://doi.org/10.1111/and.13199