공업화학 (Applied Chemistry for Engineering)

  • 제27권5호
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  • Pages.543-545
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  • 2016
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  • 1225-0112(pISSN)
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  • 2288-4505(eISSN)
한국공업화학회 (The Korean Society of Industrial and Engineering Chemistry)
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용액의 산도 및 용매의 종류에 따른 수산화인회석의 형태 변화 연구

Dependence of the Morphology of Hydroxyapatite on pH and Solvent Species

  • 김영용 (경상대학교 화학과, 경상대학교 기초과학연구소) ;
  • 권기영 (경상대학교 화학과, 경상대학교 기초과학연구소)
  • Kim, Youngyon (Department of Chemistry and RINS, Gyeongsang National University) ;
  • Kwon, Ki-Young (Department of Chemistry and RINS, Gyeongsang National University)
  • 투고 : 2016.06.15
  • 심사 : 2016.08.05
  • 발행 : 2016.10.10
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초록

본 연구에서는 용매열합성법을 이용하여 용액의 서로 다른 pH와 용매 조건에서 4종의 수산화인회석을 합성하였다. 합성된 샘플의 결정성과 형태를 X-선 회절 분석과, 투과형전자현미경을 통하여 분석하였다. 4종의 수산화인회석은 pH와 용매 조건에 관계없이 거의 유사한 형태의 XRD 패턴을 보여 주었다. 그러나 형태는 순수한 물을 용매를 사용하였을 경우 염기 조건에서 합성한 수산화인회석이 [001] 방향으로 결정이 성장한 형태를 보였으며, 또한 순수한 물에 메탄올과 에탄올이 첨가한 조건에서 합성한 수산화인회석은 [001] 방향으로 더욱더 결정이 성장한 형태를 보였다.

Four different hydroxyapatites (HAP) were prepared by a solvothermal method under different pHs and solvent species. The synthesized hydroxyapatites were analyzed by X-ray diffraction (XRD) and transmission electron microscopy (TEM). Four HAPs exhibited similar XRD patterns regardless of synthetic conditions. However, the morphology of hydroxyapatites was dependent of pH and solvent species under synthetic condition. The HAP prepared in pH 12 showed an elongated shape along the [001] direction compared to that prepared in pH 8. Also, the morphology of the HAPs synthesized in the presence of methanol and ethanol exhibited the more elongated hexagonal rod shape along the [001] direction with the high aspect ratio.

키워드

참고문헌

  1. M. I. Kay, R. A. Young, and A. S. Posner, Crystal structure of hydroxyapatite, Nature, 204, 1050-1052 (1964). https://doi.org/10.1038/2041050a0
  2. D. M. Roy and S. K. Linnehan, Hydroxyapatite formed from coral skeletal carbonate by hydrothermal exchange, Nature, 247, 220-222 (1974). https://doi.org/10.1038/247220a0
  3. H. Chen, B. H. Clarkson, K. Sun, and J. F. Mansfield, Self-assembly of synthetic hydroxyapatite nanorods into an enamel prism-like structure, J. Colloid Interface Sci., 288, 97-103 (2005). https://doi.org/10.1016/j.jcis.2005.02.064
  4. W. Suchanek and M. Yoshimura, Processing and properties of hydroxyapatite- based biomaterials for use as hard tissue replacement implants, J. Mater. Res., 13, 94-117 (1998). https://doi.org/10.1557/JMR.1998.0015
  5. G. Wei and P. X. Ma, Structure and properties of nano-hydroxyapatite/ polymer composite scaffolds for bone tissue engineering, Biomaterials, 25, 4749-4757 (2004). https://doi.org/10.1016/j.biomaterials.2003.12.005
  6. S. S. Kim, M. Sun Park, O. Jeon, C. Yong Choi, and B. S. Kim, Poly(Lactide-Co-Glycolide)/Hydroxyapatite composite scaffolds for bone tissue engineering, Biomaterials, 27, 1399-1409 (2006). https://doi.org/10.1016/j.biomaterials.2005.08.016
  7. K. Y. Kwon, E. Wang, N. Chang, and S. W. Lee, Characterization of the dominant molecular step orientations on hydroxyapatite (100) surfaces, Langmuir, 25, 7205-7208 (2009). https://doi.org/10.1021/la900824n
  8. A. C. Tas, Molten salt synthesis of calcium hydroxyapatite whiskers, J. Am. Ceram. Soc., 84, 295-300 (2001).
  9. T. S. P. Cellet, G. M. Pereira, E. C. Muniz, R. Silva, and A. F. Rubira, Hydroxyapatite nanowhiskers embedded in chondroitin sulfate microspheres as colon targeted drug delivery systems, J. Mater. Chem. B, 3, 6837-6846 (2015). https://doi.org/10.1039/C5TB00856E
  10. N. S. Sambudi, S. Cho, and K. Cho, Porous hollow hydroxyapatite microspheres synthesized by spray pyrolysis using a microalga template: Preparation, drug delivery, and bioactivity, RSC Adv., 6, 43041-43048 (2016). https://doi.org/10.1039/C6RA03147A
  11. K. Mori, T. Hara, T. Mizugaki, K. Ebitani, and K. Kaneda, Hydroxyapatite-bound cationic ruthenium complexes as novel heterogeneous lewis acid catalysts for diels-alder and aldol reactions, J. Am. Chem. Soc., 125, 11460-11461 (2003). https://doi.org/10.1021/ja0302533
  12. W. E. Brown, Octacalcium phosphate and hydroxyapatite: Crystal structure of octacalcium phosphate, Nature, 196, 1048-1050 (1962).
  13. S. Graham and P. W. Brown, Reactions of octacalcium phosphate to form hydroxyapatite, J. Cryst. Growth, 165, 106-115 (1996). https://doi.org/10.1016/0022-0248(95)00994-9
  14. Y. Kim, D. Kim, S. Lee, D. K. Woo, J. H. Byun, and K. Y. Kwon, Synthesis and morphological characterization of calcium phosphates prepared under different naoh concentrations, Bull. Korean Chem. Soc., 35, 2241-2242 (2014). https://doi.org/10.5012/bkcs.2014.35.8.2241
  15. M. Tomozawa and S. Hiromoto, Microstructure of hydroxyapatiteand octacalcium phosphate-coatings formed on magnesium by a hydrothermal treatment at various pH values, Acta Mater., 59, 355-363 (2011). https://doi.org/10.1016/j.actamat.2010.09.041
  16. J. K. Lee and H. I. Aaronson, The equilibrium shape of a particle at macroscopic steps and kinks and the gibbs-wulff construction, Surf. Sci., 47, 692-696 (1975). https://doi.org/10.1016/0039-6028(75)90217-4