생약학회지 (Korean Journal of Pharmacognosy)

  • 제47권3호
  • /
  • Pages.226-231
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  • 2016
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  • 0253-3073(pISSN)
  • /
  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

한국산 향유로부터 얻은 정유의 조성과 콜린에스테라제 억제활성

Composition and Anti-cholinesterase Activity of the Essential Oil Obtained from Korean Elsholtzia ciliata

  • Song, Byong-Min (Department of Forest Science, Sangji University) ;
  • Choi, Jae Sue (Department of Food Science and Nutrition, Pukyong National University) ;
  • Park, Hee-Juhn (Department of Pharmaceutical Engineering, Sangji University)
  • 투고 : 2016.06.27
  • 심사 : 2016.08.26
  • 발행 : 2016.09.30
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초록

The present GC-MS analysis elucidated the composition of the essential oil obtained from the herb of Elsholtzia ciliata(Lamiaceae). Overall, the content of monoterpenes was higher than that of sesquiterpenes. Monoterpenes rich in this oil were carvone (peak area, 26.180%), camphor (2.304%), borneol (9.974%), dihydrocarveol (3.296%), ${\alpha}$-citral (=geranial, 4.025%), geranic acid (2.961%), while sesquiterpenes occupying relatively higher percentage were ${\alpha}$-humulene (0.918%), (-)-spathulenol (0.974%), ${\alpha}$-caryophyllene oxide (2.014%), globulol (1.362%), ${\beta}$-caryophyllene oxide (0.750%). The components characterizing this oil were 1-octen-3-ol, acetophenone, and butylated hydroxytoluene. The $IC_{50}$ of this oil on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were $42.37{\mu}g/ml$ and $121.34{\mu}g/ml$, respectively, suggesting that the essential oil of E. ciliata may be active on the memory loss of patients suffering from Alzheimer's disease.

키워드

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