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A Korean Multi-Center Survey about Warfarin Management before Gastroenterological Endoscopy in Patients with a History of Mechanical Valve Replacement Surgery

  • Son, Kuk Hui (Department of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center, Gachon University College of Medicine) ;
  • Choi, Chang-Hyu (Department of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center, Gachon University College of Medicine) ;
  • Lee, Jae-Ik (Department of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center, Gachon University College of Medicine) ;
  • Kim, Kun Woo (Department of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center, Gachon University College of Medicine) ;
  • Kim, Ji Sung (Department of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center, Gachon University College of Medicine) ;
  • Lee, So Young (Department of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center, Gachon University College of Medicine) ;
  • Park, Kook Yang (Department of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center, Gachon University College of Medicine) ;
  • Park, Chul Hyun (Department of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center, Gachon University College of Medicine)
  • Received : 2015.08.26
  • Accepted : 2015.09.09
  • Published : 2016.10.05

Abstract

Background: Guidelines for esophagogastroduodenoscopy (EGD) in the West allow the continued use of warfarin under therapeutic international normalized ratio (INR) level. In Korea, no guidelines have been issued regarding warfarin treatment before EGD. The authors surveyed Korean cardiac surgeons about how Korean cardiac surgeons handle warfarin therapy before EGD using a questionnaire. Participants were requested to make decisions regarding the continuation of warfarin therapy in two hypothetical cases. Methods: The questionnaire was administered to cardiac surgeons and consisted of eight questions, including two case scenarios. Results: Thirty- six cardiac surgeons at 28 hospitals participated in the survey, and 52.7% of the participants chose to stop warfarin before EGD in aortic valve replacement patients without risk factors for thromboembolism. When the patient's INR level was 2, 31% of the participants indicated that they would choose to continue warfarin therapy. For EGD with biopsy, 72.2% of the participants chose warfarin withdrawal, and 25% of the participants chose heparin replacement. In mitral valve replacement patients, 47.2% of the participants chose to discontinue warfarin, and 22.2% of the participants chose heparin replacement. For EGD with biopsy in patients with a mitral valve replacement, 58.3% of the participants chose to stop warfarin, and 41.7% of the participants chose heparin replacement. Conclusion: This study demonstrated that attitudes regarding warfarin treatment for EGD are very different among Korean surgeons. Guidelines specific to the Korean population are required.

Keywords

References

  1. Bhatt DL, Scheiman J, Abraham NS, et al. ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. Circulation 2008;118:1894-909. https://doi.org/10.1161/CIRCULATIONAHA.108.191087
  2. Fujimoto K, Fujishiro M, Kato M, et al. Guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment. Dig Endosc 2014;26:1-14.
  3. ASGE Standards of Practice Committee, Anderson MA, Ben-Menachem T, et al. Management of antithrombotic agents for endoscopic procedures. Gastrointest Endosc 2009;70: 1060-70. https://doi.org/10.1016/j.gie.2009.09.040
  4. Veitch AM, Baglin TP, Gershlick AH, et al. Guidelines for the management of anticoagulant and antiplatelet therapy in patients undergoing endoscopic procedures. Gut 2008;57:1322-9. https://doi.org/10.1136/gut.2007.142497
  5. Boustiere C, Veitch A, Vanbiervliet G, et al. Endoscopy and antiplatelet agents. European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy 2011;43:445-61. https://doi.org/10.1055/s-0030-1256317
  6. Eisen GM, Baron TH, Dominitz JA, et al. Guideline on the management of anticoagulation and antiplatelet therapy for endoscopic procedures. Gastrointest Endosc 2002;55: 775-9. https://doi.org/10.1016/S0016-5107(02)70402-1
  7. Fujishiro M, Oda I, Yamamoto Y, et al. Multi-center survey regarding the management of anticoagulation and antiplatelet therapy for endoscopic procedures in Japan. J Gastroenterol Hepatol 2009;24:214-8. https://doi.org/10.1111/j.1440-1746.2008.05604.x
  8. Ogoshi K, Kaneko E, Tada M; Japan Gastroenterological Endoscopy Society Risk Management Committee. Use of anticoagulants and antiplatelet agents during endoscopic procedures. Gastroenterol Endosc 2005;47:2691-5.
  9. Wahl MJ. Dental surgery in anticoagulated patients. Arch Intern Med 1998;158:1610-6. https://doi.org/10.1001/archinte.158.15.1610
  10. Blacker DJ, Wijdicks EF, McClelland RL. Stroke risk in anticoagulated patients with atrial fibrillation undergoing endoscopy. Neurology 2003;61:964-8. https://doi.org/10.1212/01.WNL.0000086817.54076.EB
  11. Palareti G, Legnani C, Guazzaloca G, et al. Activation of blood coagulation after abrupt or stepwise withdrawal of oral anticoagulants: a prospective study. Thromb Haemost 1994;72:222-6.
  12. Sieg A, Hachmoeller-Eisenbach U, Eisenbach T. Prospective evaluation of complications in outpatient GI endoscopy: a survey among German gastroenterologists. Gastrointest Endosc 2001;53:620-7. https://doi.org/10.1067/mge.2001.114422
  13. Parra-Blanco A, Kaminaga N, Kojima T, et al. Hemoclipping for postpolypectomy and postbiopsy colonic bleeding. Gastrointest Endosc 2000;51:37-41. https://doi.org/10.1016/S0016-5107(00)70384-1
  14. Ono S, Fujishiro M, Hirano K, et al. Retrospective analysis on the management of anticoagulants and antiplatelet agents for scheduled endoscopy. J Gastroenterol 2009;44: 1185-9. https://doi.org/10.1007/s00535-009-0127-6
  15. Tono S, Morita Y, Miura M, et al. Risks associated with endoscopic biopsy procedures undertaken while administering antiplatelet drugs. Gastroenterol Endosc 2011;53: 3326-35.
  16. Lee SY, Tang SJ, Rockey DC, et al. Managing anticoagulation and antiplatelet medications in GI endoscopy: a survey comparing the East and the West. Gastrointest Endosc 2008;67:1076-81. https://doi.org/10.1016/j.gie.2007.11.037
  17. Ido K, Togashi K, Yamamoto H, et al. How antiplatelets and anticoagulants should be managed in endoscopic treatment. Gastroenterol Endosc 2004;46:2079-85.
  18. Ogoshi K, Kaneko E, Tada M, et al. The management of anticoagulation and antiplatelet therapy for endoscopic procedures. Gastroenterol Endosc 2005;47:2691-5.
  19. Lee SY, Chang DK, Park DI, et al. Multicenter survey on gastrointestinal endoscopic examination during anticoagulation or antiplatelet medications [abstract]. Korean J Gastrointest Endosc 2006;33(Suppl 2):169-70.