DOI QR코드

DOI QR Code

Neurogenic muscle hypertrophy: a case report

  • Shin, Hyun Ho (Department of Anesthesiology and Pain Medicine, Keimyung University School of Medicine) ;
  • Jeon, Young Hoon (Department of Anesthesiology and Pain Medicine, School of Dentistry, Kyungpook National University) ;
  • Jang, Seung Won (Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University) ;
  • Kim, Sae Young (Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University)
  • Received : 2016.07.20
  • Accepted : 2016.08.17
  • Published : 2016.10.01

Abstract

Muscular hypertrophy is caused mainly due to myopathic disorder. But, it is also rarely produced by neurogenic disorder. A 74-year-old woman complained of right calf pain with hypertrophy for several years. Recent lumbar spine magnetic resonance imaging (MRI) showed central and lateral canal narrowing at the L4-L5 intervertebral space. Lower extremity MRI revealed fatty change of right medial head of the gastrocnemius and soleus, causing right calf hypertrophy. Electrodiagnostic examinations including electromyography and nerve conduction velocity testing demonstrated $5^{th}$ lumbar and $1^{st}$ sacral polyradiculopathy. Integrating all the results, the diagnosis was neurogenic muscle hypertrophy. Neurogenic muscle hypertrophy is very rare, but we recommend that clinicians consider this problem when a patient complains of lower limb hypertrophy and pain.

Keywords

References

  1. Gutmann L. AAEM minimonograph #46: neurogenic muscle hypertrophy. Muscle Nerve 1996; 19: 811-8. https://doi.org/10.1002/(SICI)1097-4598(199607)19:7<811::AID-MUS1>3.0.CO;2-C
  2. Pareyson D, Morandi L, Scaioli V, Marazzi R, Boiardi A, Sghirlanzoni A. Neurogenic muscle hypertrophy. Report of two cases. J Neurol 1989; 236: 292-5. https://doi.org/10.1007/BF00314459
  3. Deffond D, Clavelou P, Colamarino R, Roche C, Dordain G, Tournilhac M. Neurogenic muscle hypertrophy: 3 cases. Rev Neurol (Paris) 1996; 152: 272-8.
  4. Krendel DA, Hedaya EV, Gottleib AJ. Calf enlargement, S1 radiculopathy, and focal myositis. Muscle Nerve 1992; 15: 517-8.
  5. Heuss D, Schober S, Eberhardt K, Probst-Cousin S, Kayser C, Hecht M, et al. Muscle hypertrophy due to scarring of the S1 nerve root. Neurol Res 2000; 22: 469-72. https://doi.org/10.1080/01616412.2000.11740702
  6. Walcott BP, Nahed BV, Redjal N, Stein TD, Kahle KT, Coumans JV. Pathological mechanism of lumbar disc herniation resulting in neurogenic muscle hypertrophy. J Clin Neurosci 2011; 18: 1682-4. https://doi.org/10.1016/j.jocn.2011.03.033
  7. Beydoun SR, Shapiro C, Engel WK. Calf muscle hypertrophy, complex repetitive discharges and spinal stenosis. Muscle Nerve 1993; 16: 322-3.
  8. Mattle HP, Hess CW, Ludin HP, Mumenthaler M. Isolated muscle hypertrophy as a sign of radicular or peripheral nerve injury. J Neurol Neurosurg Psychiatry 1991; 54: 325-9. https://doi.org/10.1136/jnnp.54.4.325
  9. Liguori R, Fuglsang-Frederiksen A, Nix W, Fawcett PR, Andersen K. Electromyography in myopathy. Neurophysiol Clin 1997; 27: 200-3. https://doi.org/10.1016/S0987-7053(97)83775-6
  10. Garmirian LP, Chin AB, Rutkove SB. Discriminating neurogenic from myopathic disease via measurement of muscle anisotropy. Muscle Nerve 2009; 39: 16-24. https://doi.org/10.1002/mus.21115
  11. Swartz KR, Fee DB, Trost GR, Waclawik AJ. Unilateral calf hypertrophy seen in lumbosacral stenosis: case report and review of the literature. Spine (Phila Pa 1976) 2002; 27: E406-9. https://doi.org/10.1097/00007632-200209150-00022
  12. Lattanzi S, Cagnetti C, Di Bella P, Scarpelli M, Provinciali L, Silvestrini M. Neurogenic muscle hypertrophy. Neurology 2014; 83: 2191. https://doi.org/10.1212/WNL.0000000000001048
  13. Costa J, Graca P, Evangelista T, de Carvalho M. Pain and calf hypertrophy associated with spontaneous repetitive discharges treated with botulinum toxin. Clin Neurophysiol 2005; 116: 2847-52. https://doi.org/10.1016/j.clinph.2005.07.016
  14. Hemmi S, Shirakawa S, Kurokawa K, Sunada Y. Unilateral calf hypertrophy and focal myositis induced by S1 radiculopathy: dramatic response to steroid treatment. BMJ Case Rep 2013; 2013: bcr2013200870.
  15. Gibson JN, Waddell G. Surgical interventions for lumbar disc prolapse. Cochrane Database Syst Rev 2007: CD001350.

Cited by

  1. Bilateral Calf Hypertrophy With Increased Muscle Enzyme Levels vol.73, pp.8, 2016, https://doi.org/10.1002/art.41707