Journal of Applied Biological Chemistry

  • 제59권3호
  • /
  • Pages.233-237
  • /
  • 2016
  • /
  • 1976-0442(pISSN)
  • /
  • 2234-7941(eISSN)
한국응용생명화학회 (The Korean Society for Applied Biological Chemistry)
권호 표지
DOI QR코드

DOI QR Code

Eye and skin irritation tests using deep sea water-extracted minerals

  • Joo, Yong Hoon (Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University) ;
  • Cho, Miju (Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University) ;
  • Lee, Do Hun (Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University) ;
  • Park, Young Sig (Functional Food Research Center, College of Life Sciences and Biotechnology, Korea University) ;
  • Chung, Namhyun (Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University)
  • 투고 : 2016.05.13
  • 심사 : 2016.05.23
  • 발행 : 2016.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Deep sea water (DSW) contains many inorganic materials and minerals, which are extracted for use in diverse fields. However, before application, safety tests should be performed. In the present study, two DSW-extracted minerals were analyzed: calcium (Ca) and magnesium (Mg). Eye and skin irritation tests of DSW-extracted Ca and Mg were performed according to the guidelines of the Ministry of Food and Drug Safety of Korea. These two types of mineral extracts caused no symptoms of eye and skin irritation when compared to the control. These results suggest that DSW-extracted minerals caused no irritation in the eyes and on the skin, and could be safely applied to these areas.

키워드

참고문헌

  1. Denda M, Katagiri C, Hirao T, Maruyama N, Takahashi M (1999) Some magnesium salts and a mixture of magnesium and calcium salts accelerate skin barrier recovery. Arch Dermatol Res. 291: 560-563 https://doi.org/10.1007/s004030050454
  2. Dickens BF, Weglicki WB, Li YS, Mak IT (1992) Magnesium deficiency in vitro enhances free radical-induced intracellular oxidation and cytotoxicity in endothelial cells. FEBS Lett 311: 187-191 https://doi.org/10.1016/0014-5793(92)81098-7
  3. Ha BG, Park JE, Shin EJ, Shon YH (2014a) Effects of balanced deep-sea water on adipocyte hypertrophy and liver steatosis in high-fat, dietinduced obese mice. Obesity 22: 1669-1678 https://doi.org/10.1002/oby.20740
  4. Ha BG, Park JE, Shin EJ, Shon YH (2014b) Modulation of glucose metabolism by balanced deep-sea water ameliorates hyperglycemia and pancreatic function in streptozotocin-induced diabetic mice. PLOS ONE 9: e102095 https://doi.org/10.1371/journal.pone.0102095
  5. Ha BG, Shin EJ, Park JE, Shon YH (2013) Anti-diabetic effect of balanced deep-sea water and its mode of action in high-fat diet induced diabetic mice. Mar Drugs 11: 4193-4212 https://doi.org/10.3390/md11114193
  6. Jones KW, Eller LK, Parnell JA, Doyle-Baker PK, Edwards AL, Reimer RA (2013) Effect of a dairy- and calcium-rich diet on weight loss and appetite during energy restriction in overweight and obese adults: a randomized trial. Eur J Clin Nutr 67: 371-376 https://doi.org/10.1038/ejcn.2013.52
  7. Kaur J (2014) A comprehensive review on metabolic syndrome. Cardiol Res Pract 2014: 943162
  8. Li K, Kaaks R, Linseisen J, Rohrmann S (2012) Associations of dietary calcium intake and calcium supplementation with myocardial infarction and stroke risk and overall cardiovascular mortality in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition study (EPIC-Heidelberg). Heart 98: 920-925 https://doi.org/10.1136/heartjnl-2011-301345
  9. Li PC, Pan CH, Sheu MJ, Wu CC, Ma WF, Wu CH (2014) Deep sea water prevents balloon angioplasty-induced hyperplasia through MMP-2: an in vitro and in vivo study. PLOS ONE 9: e96927 https://doi.org/10.1371/journal.pone.0096927
  10. Lin CY, Tsai PS, Hung YC, Huang CJ (2010) L-type calcium channels are involved in mediating the anti-inflammatory effects of magnesium sulphate. Br J Anaesth 104: 44-51 https://doi.org/10.1093/bja/aep336
  11. Pachikian BD, Neyrinck AM, Deldicque L, Fabienne CDB, Catry E, Dewulf EM, Sohet FM, Bindels LB, Everard A, Francaux M, Guiot Y, Cani PD, Delzenne NM (2010) Changes in intestinal bifidobacteria levels are associated with the inflammatory response in magnesium-deficient mice. J Nutr 140: 509-514 https://doi.org/10.3945/jn.109.117374
  12. Seelig MS and Rosanoff A (2003) The magnesium factor. Penguin, New York
  13. Shechter M (2010) Magnesium and cardiovascular system. Magnes Res 23: 60-72
  14. Shechter M, Sherer Y (2003) Endothelial dysfunction: a crystal ball prediction for enhanced cardiovascular risk? Isr Med Assoc J 5: 736-738
  15. Sheu MJ, Chou PY, Lin WH, Pan CH, Chien YC, Chung YL, Liu FC, Wu CH (2013) Deep sea water modulates blood pressure and exhibits hypolipidemic effects via the AMPK-ACC pathway: an in vivo study. Mar Drugs 11: 2183-2202 https://doi.org/10.3390/md11062183
  16. Villegas R, Gao YT, Dia Q, Yang G, Cai H, Li H, Zheng W, Shu XO (2009) Dietary calcium and magnesium intakes and the risk of type 2 diabetes: the Shanghai Women's Health Study. Am J Clin Nutr 89: 1059-1067 https://doi.org/10.3945/ajcn.2008.27182
  17. Yang CC, Yao CA, Lin YR, Yang JC, Chien CT (2014) Deep-sea water containing selenium provides intestinal protection against duodenal ulcers through the upregulation of Bcl-2 and thioredoxin reductase 1. PLOS ONE 9: e96006 https://doi.org/10.1371/journal.pone.0096006
  18. Yoda K, Sun X, Kawase M, Kubota A, Miyazawa K, Harata G, Hosoda M, Hiramatsu M, He F, Zemel MB (2015) A combination of probiotics and whey proteins enhances anti-obesity effects of calcium and dairy products during nutritional energy restriction in aP2-agouti transgenic mice. Br J Nutr 113: 1689-1696 https://doi.org/10.1017/S0007114515000914

피인용 문헌

  1. Eye and skin irritation tests to assess the safety of Jeju saline groundwater vol.60, pp.3, 2017, https://doi.org/10.3839/jabc.2017.039