Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Physiologic Assessment of Coronary Artery Disease: Focus on Fractional Flow Reserve

  • Hwang, Doyeon (Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital) ;
  • Lee, Joo Myung (Department of Internal Medicine and Cardiovascular Center, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Koo, Bon-Kwon (Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital)
  • Received : 2016.02.04
  • Accepted : 2016.02.29
  • Published : 2016.06.01
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Abstract

The presence of myocardial ischemia is the most important prognostic factor in patients with ischemic heart disease. Fractional flow reserve (FFR) is a gold standard invasive method used to detect the stenosis-specific myocardial ischemia. FFR-guided revascularization strategy is superior to angiography-guided strategy. The recently developed hyperemia-free index, instantaneous wave free ratio is being actively investigated. A non-invasive FFR derived from coronary CT angiography is now used in clinical practice. Due to rapid expansion of invasive and non-invasive physiologic assessment, comprehensive understanding of the role and potential pitfalls of each modality are required for its application. In this review, we focus on the basic and clinical aspects of physiologic assessment in ischemic heart disease.

Keywords

References

  1. Shaw LJ, Berman DS, Maron DJ, Mancini GB, Hayes SW, Hartigan PM, et al. Optimal medical therapy with or without percutaneous coronary intervention to reduce ischemic burden: results from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial nuclear substudy. Circulation 2008;117:1283-1291 https://doi.org/10.1161/CIRCULATIONAHA.107.743963
  2. Shaw LJ, Iskandrian AE. Prognostic value of gated myocardial perfusion SPECT. J Nucl Cardiol 2004;11:171-185 https://doi.org/10.1016/j.nuclcard.2003.12.004
  3. Patel MR, Peterson ED, Dai D, Brennan JM, Redberg RF, Anderson HV, et al. Low diagnostic yield of elective coronary angiography. N Engl J Med 2010;362:886-895 https://doi.org/10.1056/NEJMoa0907272
  4. Young DF, Cholvin NR, Kirkeeide RL, Roth AC. Hemodynamics of arterial stenoses at elevated flow rates. Circ Res 1977;41:99-107 https://doi.org/10.1161/01.RES.41.1.99
  5. Pijls NH, van Son JA, Kirkeeide RL, De Bruyne B, Gould KL. Experimental basis of determining maximum coronary, myocardial, and collateral blood flow by pressure measurements for assessing functional stenosis severity before and after percutaneous transluminal coronary angioplasty. Circulation 1993;87:1354-1367 https://doi.org/10.1161/01.CIR.87.4.1354
  6. Pijls NH, De Bruyne B, Peels K, Van Der Voort PH, Bonnier HJ, Bartunek J, et al. Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses. N Engl J Med 1996;334:1703-1708 https://doi.org/10.1056/NEJM199606273342604
  7. Koo BK. The present and future of fractional flow reserve. Circ J 2014;78:1048-1054 https://doi.org/10.1253/circj.CJ-14-0249
  8. Kern MJ, Samady H. Current concepts of integrated coronary physiology in the catheterization laboratory. J Am Coll Cardiol 2010;55:173-185 https://doi.org/10.1016/j.jacc.2009.06.062
  9. de Bruyne B, Bartunek J, Sys SU, Pijls NH, Heyndrickx GR, Wijns W. Simultaneous coronary pressure and flow velocity measurements in humans. Feasibility, reproducibility, and hemodynamic dependence of coronary flow velocity reserve, hyperemic flow versus pressure slope index, and fractional flow reserve. Circulation 1996;94:1842-1849 https://doi.org/10.1161/01.CIR.94.8.1842
  10. Mosher P, Ross J Jr, Mcfate PA, Shaw RF. Control of coronary blood flow by an autoregulatory mechanism. Circ Res 1964;14:250-259 https://doi.org/10.1161/01.RES.14.3.250
  11. Pijls NH, van Nunen LX. Fractional flow reserve, maximum hyperemia, adenosine, and regadenoson. Cardiovasc Revasc Med 2015;16:263-265 https://doi.org/10.1016/j.carrev.2015.06.003
  12. Adjedj J, Toth GG, Johnson NP, Pellicano M, Ferrara A, Flore V, et al. Intracoronary adenosine: dose-response relationship with hyperemia. JACC Cardiovasc Interv 2015;8:1422-1430 https://doi.org/10.1016/j.jcin.2015.04.028
  13. Jang HJ, Koo BK, Lee HS, Park JB, Kim JH, Seo MK, et al. Safety and efficacy of a novel hyperaemic agent, intracoronary nicorandil, for invasive physiological assessments in the cardiac catheterization laboratory. Eur Heart J 2013;34:2055-2062 https://doi.org/10.1093/eurheartj/eht040
  14. Kato D, Takashima H, Waseda K, Kurita A, Kuroda Y, Kosaka T, et al. Feasibility and safety of intracoronary nicorandil infusion as a novel hyperemic agent for fractional flow reserve measurements. Heart Vessels 2015;30:477-483 https://doi.org/10.1007/s00380-014-0508-5
  15. Kang DY, Lee JM, Kato D, Oi M, Toyofuku M, Takashima H, et al. TCT-297 Safety and efficacy of intracoronary nicorandil as hyperemic agent for invasive physiological assessment: patient-level pooled analysis of current evidence. J Am Coll Cardiol 2015;66(15_S). http://dx.doi.org/10.1016/j.jacc.2015.08.312
  16. Iskandrian AE, Bateman TM, Belardinelli L, Blackburn B, Cerqueira MD, Hendel RC, et al. Adenosine versus regadenoson comparative evaluation in myocardial perfusion imaging: results of the ADVANCE phase 3 multicenter international trial. J Nucl Cardiol 2007;14:645-658 https://doi.org/10.1016/j.nuclcard.2007.06.114
  17. Al Jaroudi W, Iskandrian AE. Regadenoson: a new myocardial stress agent. J Am Coll Cardiol 2009;54:1123-1130 https://doi.org/10.1016/j.jacc.2009.04.089
  18. Lim WH, Koo BK, Nam CW, Doh JH, Park JJ, Yang HM, et al. Variability of fractional flow reserve according to the methods of hyperemia induction. Catheter Cardiovasc Interv 2015;85:970-976 https://doi.org/10.1002/ccd.25752
  19. Bech GJ, De Bruyne B, Pijls NH, de Muinck ED, Hoorntje JC, Escaned J, et al. Fractional flow reserve to determine the appropriateness of angioplasty in moderate coronary stenosis: a randomized trial. Circulation 2001;103:2928-2934 https://doi.org/10.1161/01.CIR.103.24.2928
  20. Pijls NH, van Schaardenburgh P, Manoharan G, Boersma E, Bech JW, van't Veer M, et al. Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER Study. J Am Coll Cardiol 2007;49:2105-2111 https://doi.org/10.1016/j.jacc.2007.01.087
  21. Zimmermann FM, Ferrara A, Johnson NP, van Nunen LX, Escaned J, Albertsson P, et al. Deferral vs. performance of percutaneous coronary intervention of functionally non-significant coronary stenosis: 15-year follow-up of the DEFER trial. Eur Heart J 2015;36:3182-3188 https://doi.org/10.1093/eurheartj/ehv452
  22. Tonino PA, De Bruyne B, Pijls NH, Siebert U, Ikeno F, van't Veer M, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med 2009;360:213-224 https://doi.org/10.1056/NEJMoa0807611
  23. Pijls NH, Fearon WF, Tonino PA, Siebert U, Ikeno F, Bornschein B, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention in patients with multivessel coronary artery disease: 2-year follow-up of the FAME (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) study. J Am Coll Cardiol 2010;56:177-184 https://doi.org/10.1016/j.jacc.2010.04.012
  24. van Nunen LX, Zimmermann FM, Tonino PA, Barbato E, Baumbach A, Engstrom T, et al. Fractional flow reserve versus angiography for guidance of PCI in patients with multivessel coronary artery disease (FAME): 5-year follow-up of a randomised controlled trial. Lancet 2015;386:1853-1860 https://doi.org/10.1016/S0140-6736(15)00057-4
  25. De Bruyne B, Pijls NH, Kalesan B, Barbato E, Tonino PA, Piroth Z, et al. Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease. N Engl J Med 2012;367:991-1001 https://doi.org/10.1056/NEJMoa1205361
  26. De Bruyne B, Fearon WF, Pijls NH, Barbato E, Tonino P, Piroth Z, et al. Fractional flow reserve-guided PCI for stable coronary artery disease. N Engl J Med 2014;371:1208-1217 https://doi.org/10.1056/NEJMoa1408758
  27. Kolh P, Windecker S, Alfonso F, Collet JP, Cremer J, Falk V, et al. 2014 ESC/EACTS Guidelines on myocardial revascularization: the Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur J Cardiothorac Surg 2014;46:517-592 https://doi.org/10.1093/ejcts/ezu366
  28. Park SH, Jeon KH, Lee JM, Nam CW, Doh JH, Lee BK, et al. Long-term clinical outcomes of fractional flow reserve-guided versus routine drug-eluting stent implantation in patients with intermediate coronary stenosis: five-year clinical outcomes of DEFER-DES trial. Circ Cardiovasc Interv 2015;8. pii: e002442
  29. Li J, Elrashidi MY, Flammer AJ, Lennon RJ, Bell MR, Holmes DR, et al. Long-term outcomes of fractional flow reserve-guided vs. angiography-guided percutaneous coronary intervention in contemporary practice. Eur Heart J 2013;34:1375-1383 https://doi.org/10.1093/eurheartj/eht005
  30. Park SJ, Ahn JM, Park GM, Cho YR, Lee JY, Kim WJ, et al. Trends in the outcomes of percutaneous coronary intervention with the routine incorporation of fractional flow reserve in real practice. Eur Heart J 2013;34:3353-3361 https://doi.org/10.1093/eurheartj/eht404
  31. Frohlich GM, Redwood S, Rakhit R, MacCarthy PA, Lim P, Crake T, et al. Long-term survival in patients undergoing percutaneous interventions with or without intracoronary pressure wire guidance or intracoronary ultrasonographic imaging: a large cohort study. JAMA Intern Med 2014;174:1360-1366 https://doi.org/10.1001/jamainternmed.2014.1595
  32. Fearon WF, Yeung AC, Lee DP, Yock PG, Heidenreich PA. Cost-effectiveness of measuring fractional flow reserve to guide coronary interventions. Am Heart J 2003;145:882-887 https://doi.org/10.1016/S0002-8703(03)00072-3
  33. Siebert U, Arvandi M, Gothe RM, Bornschein B, Eccleston D, Walters DL, et al. Improving the quality of percutaneous revascularisation in patients with multivessel disease in Australia: cost-effectiveness, public health implications, and budget impact of FFR-guided PCI. Heart Lung Circ 2014;23:527-533 https://doi.org/10.1016/j.hlc.2013.12.009
  34. Johnson NP, Toth GG, Lai D, Zhu H, Acar G, Agostoni P, et al. Prognostic value of fractional flow reserve: linking physiologic severity to clinical outcomes. J Am Coll Cardiol 2014;64:1641-1654 https://doi.org/10.1016/j.jacc.2014.07.973
  35. Davies JE, Whinnett ZI, Francis DP, Manisty CH, Aguado-Sierra J, Willson K, et al. Evidence of a dominant backward-propagating "suction" wave responsible for diastolic coronary filling in humans, attenuated in left ventricular hypertrophy. Circulation 2006;113:1768-1778 https://doi.org/10.1161/CIRCULATIONAHA.105.603050
  36. Siebes M, Kolyva C, Verhoeff BJ, Piek JJ, Spaan JA. Potential and limitations of wave intensity analysis in coronary arteries. Med Biol Eng Comput 2009;47:233-239 https://doi.org/10.1007/s11517-009-0448-x
  37. Sen S, Escaned J, Malik IS, Mikhail GW, Foale RA, Mila R, et al. Development and validation of a new adenosine-independent index of stenosis severity from coronary wave-intensity analysis: results of the ADVISE (ADenosine Vasodilator Independent Stenosis Evaluation) study. J Am Coll Cardiol 2012;59:1392-1402 https://doi.org/10.1016/j.jacc.2011.11.003
  38. Berry C, van't Veer M, Witt N, Kala P, Bocek O, Pyxaras SA, et al. VERIFY (VERification of Instantaneous Wave-Free Ratio and Fractional Flow Reserve for the Assessment of Coronary Artery Stenosis Severity in EverydaY Practice): a multicenter study in consecutive patients. J Am Coll Cardiol 2013;61:1421-1427 https://doi.org/10.1016/j.jacc.2012.09.065
  39. Park JJ, Petraco R, Nam CW, Doh JH, Davies J, Escaned J, et al. Clinical validation of the resting pressure parameters in the assessment of functionally significant coronary stenosis; results of an independent, blinded comparison with fractional flow reserve. Int J Cardiol 2013;168:4070-4075 https://doi.org/10.1016/j.ijcard.2013.07.030
  40. Sen S, Asrress KN, Nijjer S, Petraco R, Malik IS, Foale RA, et al. Diagnostic classification of the instantaneous wave-free ratio is equivalent to fractional flow reserve and is not improved with adenosine administration. Results of CLARIFY (Classification Accuracy of Pressure-Only Ratios Against Indices Using Flow Study). J Am Coll Cardiol 2013;61:1409-1420 https://doi.org/10.1016/j.jacc.2013.01.034
  41. Jeremias A, Maehara A, Genereux P, Asrress KN, Berry C, De Bruyne B, et al. Multicenter core laboratory comparison of the instantaneous wave-free ratio and resting Pd/Pa with fractional flow reserve: the RESOLVE study. J Am Coll Cardiol 2014;63:1253-1261 https://doi.org/10.1016/j.jacc.2013.09.060
  42. Gotberg M, Christiansen EH, Gudmundsdottir I, Sandhall L, Omerovic E, James SK, et al. Instantaneous Wave-Free Ratio versus Fractional Flow Reserve guided intervention (iFR-SWEDEHEART): rationale and design of a multicenter, prospective, registry-based randomized clinical trial. Am Heart J 2015;170:945-950 https://doi.org/10.1016/j.ahj.2015.07.031
  43. Johnson NP, Kirkeeide RL, Gould KL. Coronary anatomy to predict physiology: fundamental limits. Circ Cardiovasc Imaging 2013;6:817-832 https://doi.org/10.1161/CIRCIMAGING.113.000373
  44. Kern MJ. Seeing and not believing: understanding the visual-functional mismatch between angiography and FFR. Catheter Cardiovasc Interv 2014;84:414-415 https://doi.org/10.1002/ccd.25616
  45. Tonino PA, Fearon WF, De Bruyne B, Oldroyd KG, Leesar MA, Ver Lee PN, et al. Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography in multivessel evaluation. J Am Coll Cardiol 2010;55:2816-2821 https://doi.org/10.1016/j.jacc.2009.11.096
  46. Park SJ, Kang SJ, Ahn JM, Shim EB, Kim YT, Yun SC, et al. Visual-functional mismatch between coronary angiography and fractional flow reserve. JACC Cardiovasc Interv 2012;5:1029-1036 https://doi.org/10.1016/j.jcin.2012.07.007
  47. Waksman R, Legutko J, Singh J, Orlando Q, Marso S, Schloss T, et al. FIRST: Fractional Flow Reserve and Intravascular Ultrasound Relationship Study. J Am Coll Cardiol 2013;61:917-923 https://doi.org/10.1016/j.jacc.2012.12.012
  48. Chantadansuwan T, Kehasukcharoen W, Kanoksilp A, Saejueng B, Plainetr V, Sukhavasharin N, et al. Visual-functional mismatch and results of fractional flow reserve guided percutaneous coronary revascularization. J Med Assoc Thai 2014;97:1064-1076
  49. Cho YK, Nam CW, Han JK, Koo BK, Doh JH, Ben-Dor I, et al. Usefulness of combined intravascular ultrasound parameters to predict functional significance of coronary artery stenosis and determinants of mismatch. EuroIntervention 2015;11:163-170 https://doi.org/10.4244/EIJV11I2A30
  50. Cho HO, Nam CW, Cho YK, Yoon HJ, Park HS, Kim H, et al. Characteristics of function-anatomy mismatch in patients with coronary artery disease. Korean Circ J 2014;44:394-399 https://doi.org/10.4070/kcj.2014.44.6.394
  51. Taylor CA, Fonte TA, Min JK. Computational fluid dynamics applied to cardiac computed tomography for noninvasive quantification of fractional flow reserve: scientific basis. J Am Coll Cardiol 2013;61:2233-2241 https://doi.org/10.1016/j.jacc.2012.11.083
  52. Kochar M, Min JK. Physiologic assessment of coronary artery disease by cardiac computed tomography. Korean Circ J 2013;43:435-442 https://doi.org/10.4070/kcj.2013.43.7.435
  53. Koo BK, Lee JM, Taylor C. Chapter 35. Computational fluid dynamics applied to multidetector coronary angiography (FFR-CT). In: Escaned J, Serruys PW, eds. Coronary stenosis: imaging, structure, and physiology, 2nd ed. EUROPA Digital & Publishing, 2015
  54. Koo BK, Erglis A, Doh JH, Daniels DV, Jegere S, Kim HS, et al. Diagnosis of ischemia-causing coronary stenoses by noninvasive fractional flow reserve computed from coronary computed tomographic angiograms. Results from the prospective multicenter DISCOVER-FLOW (Diagnosis of Ischemia-Causing Stenoses Obtained Via Noninvasive Fractional Flow Reserve) study. J Am Coll Cardiol 2011;58:1989-1997 https://doi.org/10.1016/j.jacc.2011.06.066
  55. Min JK, Leipsic J, Pencina MJ, Berman DS, Koo BK, van Mieghem C, et al. Diagnostic accuracy of fractional flow reserve from anatomic CT angiography. JAMA 2012;308:1237-1245 https://doi.org/10.1001/2012.jama.11274
  56. Norgaard BL, Leipsic J, Gaur S, Seneviratne S, Ko BS, Ito H, et al. Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease: the NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps). J Am Coll Cardiol 2014;63:1145-1155 https://doi.org/10.1016/j.jacc.2013.11.043
  57. Hlatky MA, Saxena A, Koo BK, Erglis A, Zarins CK, Min JK. Projected costs and consequences of computed tomography-determined fractional flow reserve. Clin Cardiol 2013;36:743-748 https://doi.org/10.1002/clc.22205
  58. Kimura T, Shiomi H, Kuribayashi S, Isshiki T, Kanazawa S, Ito H, et al. Cost analysis of non-invasive fractional flow reserve derived from coronary computed tomographic angiography in Japan. Cardiovasc Interv Ther 2015;30:38-44 https://doi.org/10.1007/s12928-014-0285-1
  59. Douglas PS, Pontone G, Hlatky MA, Patel MR, Norgaard BL, Byrne RA, et al. Clinical outcomes of fractional flow reserve by computed tomographic angiography-guided diagnostic strategies vs. usual care in patients with suspected coronary artery disease: the prospective longitudinal trial of FFRCT: outcome and resource impacts study. Eur Heart J 2015;36:3359-3367 https://doi.org/10.1093/eurheartj/ehv444
  60. Kim KH, Doh JH, Koo BK, Min JK, Erglis A, Yang HM, et al. A novel noninvasive technology for treatment planning using virtual coronary stenting and computed tomography-derived computed fractional flow reserve. JACC Cardiovasc Interv 2014;7:72-78 https://doi.org/10.1016/j.jcin.2013.05.024
  61. Coenen A, Lubbers MM, Kurata A, Kono A, Dedic A, Chelu RG, et al. Fractional flow reserve computed from noninvasive CT angiography data: diagnostic performance of an on-site clinician-operated computational fluid dynamics algorithm. Radiology 2015;274:674-683 https://doi.org/10.1148/radiol.14140992
  62. Kwon SS, Chung EC, Park JS, Kim GT, Kim JW, Kim KH, et al. A novel patient-specific model to compute coronary fractional flow reserve. Prog Biophys Mol Biol 2014;116:48-55 https://doi.org/10.1016/j.pbiomolbio.2014.09.003
  63. Yang DH, Kim YH, Roh JH, Kang JW, Han D, Jung J, et al. Stress myocardial perfusion CT in patients suspected of having coronary artery disease: visual and quantitative analysis-validation by using fractional flow reserve. Radiology 2015;276:715-723 https://doi.org/10.1148/radiol.2015141126
  64. Choi G, Lee JM, Kim HJ, Park JB, Sankaran S, Otake H, et al. Coronary artery axial plaque stress and its relationship with lesion geometry: application of computational fluid dynamics to coronary CT angiography. JACC Cardiovasc Imaging 2015;8:1156-1166 https://doi.org/10.1016/j.jcmg.2015.04.024
  65. Authors/Task Force members, Windecker S, Kolh P, Alfonso F, Collet JP, Cremer J, et al. 2014 ESC/EACTS Guidelines on myocardial revascularization: the task force on myocardial revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS) developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur Heart J 2014;35:2541-2619 https://doi.org/10.1093/eurheartj/ehu278
  66. Toth G, Hamilos M, Pyxaras S, Mangiacapra F, Nelis O, De Vroey F, et al. Evolving concepts of angiogram: fractional flow reserve discordances in 4000 coronary stenoses. Eur Heart J 2014;35:2831-2838 https://doi.org/10.1093/eurheartj/ehu094
  67. Camici PG, Crea F. Coronary microvascular dysfunction. N Engl J Med 2007;356:830-840 https://doi.org/10.1056/NEJMra061889
  68. van de Hoef TP, Bax M, Damman P, Delewi R, Hassell ME, Piek MA, et al. Impaired coronary autoregulation is associated with long-term fatal events in patients with stable coronary artery disease. Circ Cardiovasc Interv 2013;6:329-335 https://doi.org/10.1161/CIRCINTERVENTIONS.113.000378
  69. van de Hoef TP, van Lavieren MA, Damman P, Delewi R, Piek MA, Chamuleau SA, et al. Physiological basis and long-term clinical outcome of discordance between fractional flow reserve and coronary flow velocity reserve in coronary stenoses of intermediate severity. Circ Cardiovasc Interv 2014;7:301-311 https://doi.org/10.1161/CIRCINTERVENTIONS.113.001049
  70. Meuwissen M, Chamuleau SA, Siebes M, de Winter RJ, Koch KT, Dijksman LM, et al. The prognostic value of combined intracoronary pressure and blood flow velocity measurements after deferral of percutaneous coronary intervention. Catheter Cardiovasc Interv 2008;71:291-297 https://doi.org/10.1002/ccd.21331
  71. Yong AS, Ho M, Shah MG, Ng MK, Fearon WF. Coronary microcirculatory resistance is independent of epicardial stenosis. Circ Cardiovasc Interv 2012;5:103-108, S1-S2 https://doi.org/10.1161/CIRCINTERVENTIONS.111.966556
  72. Melikian N, Vercauteren S, Fearon WF, Cuisset T, MacCarthy PA, Davidavicius G, et al. Quantitative assessment of coronary microvascular function in patients with and without epicardial atherosclerosis. EuroIntervention 2010;5:939-945 https://doi.org/10.4244/EIJV5I8A158
  73. Echavarria-Pinto M, Gonzalo N, Ibanez B, Petraco R, Jimenez-Quevedo P, Sen S, et al. Low coronary microcirculatory resistance associated with profound hypotension during intravenous adenosine infusion: implications for the functional assessment of coronary stenoses. Circ Cardiovasc Interv 2014;7:35-42 https://doi.org/10.1161/CIRCINTERVENTIONS.113.000659
  74. Luo C, Long M, Hu X, Huang Z, Hu C, Gao X, et al. Thermodilution-derived coronary microvascular resistance and flow reserve in patients with cardiac syndrome X. Circ Cardiovasc Interv 2014;7:43-48 https://doi.org/10.1161/CIRCINTERVENTIONS.113.000953
  75. Cuisset T, Hamilos M, Melikian N, Wyffels E, Sarma J, Sarno G, et al. Direct stenting for stable angina pectoris is associated with reduced periprocedural microcirculatory injury compared with stenting after pre-dilation. J Am Coll Cardiol 2008;51:1060-1065 https://doi.org/10.1016/j.jacc.2007.11.059
  76. Fearon WF, Shah M, Ng M, Brinton T, Wilson A, Tremmel JA, et al. Predictive value of the index of microcirculatory resistance in patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol 2008;51:560-565 https://doi.org/10.1016/j.jacc.2007.08.062
  77. McGeoch R, Watkins S, Berry C, Steedman T, Davie A, Byrne J, et al. The index of microcirculatory resistance measured acutely predicts the extent and severity of myocardial infarction in patients with ST-segment elevation myocardial infarction. JACC Cardiovasc Interv 2010;3:715-722 https://doi.org/10.1016/j.jcin.2010.04.009
  78. Fujii K, Kawasaki D, Oka K, Akahori H, Iwasaku T, Fukunaga M, et al. The impact of pravastatin pre-treatment on periprocedural microcirculatory damage in patients undergoing percutaneous coronary intervention. JACC Cardiovasc Interv 2011;4:513-520 https://doi.org/10.1016/j.jcin.2011.02.005
  79. Layland JJ, Whitbourn RJ, Burns AT, Somaratne J, Leitl G, Macisaac AI, et al. The index of microvascular resistance identifies patients with periprocedural myocardial infarction in elective percutaneous coronary intervention. Heart 2012;98:1492-1497 https://doi.org/10.1136/heartjnl-2012-302252
  80. Ng MK, Yong AS, Ho M, Shah MG, Chawantanpipat C, O'Connell R, et al. The index of microcirculatory resistance predicts myocardial infarction related to percutaneous coronary intervention. Circ Cardiovasc Interv 2012;5:515-522 https://doi.org/10.1161/CIRCINTERVENTIONS.112.969048
  81. Fearon WF, Low AF, Yong AS, McGeoch R, Berry C, Shah MG, et al. Prognostic value of the Index of Microcirculatory Resistance measured after primary percutaneous coronary intervention. Circulation 2013;127:2436-2441 https://doi.org/10.1161/CIRCULATIONAHA.112.000298
  82. Jeremias A, Whitbourn RJ, Filardo SD, Fitzgerald PJ, Cohen DJ, Tuzcu EM, et al. Adequacy of intracoronary versus intravenous adenosine-induced maximal coronary hyperemia for fractional flow reserve measurements. Am Heart J 2000;140:651-657 https://doi.org/10.1067/mhj.2000.109920
  83. De Bruyne B, Pijls NH, Barbato E, Bartunek J, Bech JW, Wijns W, et al. Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine, and contrast medium to assess fractional flow reserve in humans. Circulation 2003;107:1877-1883 https://doi.org/10.1161/01.CIR.0000061950.24940.88
  84. Koo BK, Kim CH, Na SH, Youn TJ, Chae IH, Choi DJ, et al. Intracoronary continuous adenosine infusion. Circ J 2005;69:908-912 https://doi.org/10.1253/circj.69.908
  85. Yoon MH, Tahk SJ, Yang HM, Park JS, Zheng M, Lim HS, et al. Comparison of the intracoronary continuous infusion method using a microcatheter and the intravenous continuous adenosine infusion method for inducing maximal hyperemia for fractional flow reserve measurement. Am Heart J 2009;157:1050-1056 https://doi.org/10.1016/j.ahj.2009.03.012
  86. Seo MK, Koo BK, Kim JH, Shin DH, Yang HM, Park KW, et al. Comparison of hyperemic efficacy between central and peripheral venous adenosine infusion for fractional flow reserve measurement. Circ Cardiovasc Interv 2012;5:401-405 https://doi.org/10.1161/CIRCINTERVENTIONS.111.965392
  87. Arumugham P, Figueredo VM, Patel PB, Morris DL. Comparison of intravenous adenosine and intravenous regadenoson for the measurement of pressure-derived coronary fractional flow reserve. EuroIntervention 2013;8:1166-1171 https://doi.org/10.4244/EIJV8I10A180
  88. Prasad A, Zareh M, Doherty R, Gopal A, Vora H, Somma K, et al. Use of regadenoson for measurement of fractional flow reserve. Catheter Cardiovasc Interv 2014;83:369-374 https://doi.org/10.1002/ccd.25055
  89. van Nunen LX, Lenders GD, Schampaert S, van't Veer M, Wijnbergen I, Brueren GR, et al. Single bolus intravenous regadenoson injection versus central venous infusion of adenosine for maximum coronary hyperaemia in fractional flow reserve measurement. EuroIntervention 2015;11:905-913 https://doi.org/10.4244/EIJY14M08_10

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