Korean Journal of Radiology

  • 제17권1호
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  • Pages.151-158
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  • 2016
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  • 1229-6929(pISSN)
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  • 2005-8330(eISSN)
대한영상의학회 (The Korean Society of Radiology)
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A New Flow-Diverter (the FloWise): In-Vivo Evaluation in an Elastase-Induced Rabbit Aneurysm Model

  • Kim, Byung Moon (Severance Integrated Research Institute of Cerebrovascular Disease, Yonsei University College of Medicine) ;
  • Kim, Dong Joon (Severance Integrated Research Institute of Cerebrovascular Disease, Yonsei University College of Medicine) ;
  • Kim, Dong Ik (Severance Integrated Research Institute of Cerebrovascular Disease, Yonsei University College of Medicine)
  • 투고 : 2015.06.25
  • 심사 : 2015.10.26
  • 발행 : 2016.02.01
⟨ 이전 논문 다음 논문 ⟩

초록

Objective: We aimed to evaluate the efficacy and safety of a newly developed, partially retrievable flow-diverter (the FloWise) in an elastase-induced rabbit aneurysm model. Materials and Methods: We developed a partially retrievable flow diverter composed of 48 strands of Nitinol and platinum wire. The FloWise is compatible with any microcatheter of 0.027-inch inner diameter, and is retrievable up to 70% deployment. The efficacy and safety of the FloWise were evaluated in the elastase-induced rabbit aneurysm model. The rate of technical success (full coverage of aneurysm neck) and assessment of aneurysm occlusion and stent patency was conducted by angiograms and histologic examinations at the 1-month, 3-month, and 6-month follow-up. The patency of small arterial branches (intercostal or lumbar arteries) covered by the FloWise were also assessed in the 5 subjects. Results: We attempted FloWise insertion in a total of 32 aneurysm models. FloWise placement was successful in 31 subjects (96.9%). Two stents (6.2%) were occluded at the 3-month follow-up, but there was no evidence of in-stent stenosis in other subjects. All stented aneurysms showed progressive occlusion: grade I (complete aneurysm occlusion) in 44.4% and grade II (aneurysm occlusion > 90%) in 55.6% at 1 month; grade I in 90% and II in 10% at 3 months; and grade I in 90% and II in 10% at 6 months. All small arterial branches covered by the FloWise remained patent. Conclusion: A newly developed, partially retrievable flow-diverter seems to be a safe and effective tool of aneurysm occlusion, as evaluated in the rabbit aneurysm model.

키워드

과제정보

연구 과제 주관 기관 : Korea Health Industry Development Institute (KHIDI)

참고문헌

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피인용 문헌

  1. A Novel Flow Diverter (Tubridge) for the Treatment of Recurrent Aneurysms: A Single-Center Experience vol.18, pp.5, 2017, https://doi.org/10.3348/kjr.2017.18.5.852
  2. Update on flow diverters for the endovascular management of cerebral aneurysms vol.42, pp.6, 2017, https://doi.org/10.3171/2017.3.focus16427
  3. Update on flow diverters for the endovascular management of cerebral aneurysms vol.42, pp.6, 2017, https://doi.org/10.3171/2017.3.focus16427
  4. A Newly-Developed Flow Diverter (FloWise) for Internal Carotid Artery Aneurysm: Results of a Pilot Clinical Study vol.20, pp.3, 2019, https://doi.org/10.3348/kjr.2018.0421
  5. Tissue-engineered aneurysm models for in vitro assessment of neurovascular devices vol.61, pp.6, 2016, https://doi.org/10.1007/s00234-019-02197-x
  6. An Effective and Simple Way to Establish Elastase-Induced Middle Carotid Artery Fusiform Aneurysms in Rabbits vol.2020, pp.None, 2016, https://doi.org/10.1155/2020/6707012
  7. Promoting endothelialization of flow-diverting stents: a review vol.13, pp.1, 2016, https://doi.org/10.1136/neurintsurg-2020-015874