Acknowledgement
Grant : 옥수수수염과 들깻잎 복합물의 기능 성분을 활용한 옥수수 라떼 개발
Supported by : 중소기업청
Journal of Radiation Industry (방사선산업학회지)
- Volume 10 Issue 4
- /
- Pages.231-242
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- 2016
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- 1976-2402(pISSN)
Improvement Effect of Corn Silk, Perilla Leaf and Grape Stem Extract Mixture against UVB-Induced Skin Damage and Compound 48/80-Induced Pruritus
옥수수수염, 들깻잎 및 포도줄기 복합추출물의 UVB 조사 피부 손상 및 Compound 48/80 유도 가려움증 개선 효과
- Cho, Byoung Ok (Ato Q&A Coperation) ;
- Shin, Jae Young (Department of Healthcare & Science, Jeonju University) ;
- Che, Denis Nchang (Department of Healthcare & Science, Jeonju University) ;
- Hwang, Young Min (Department of Healthcare & Science, Jeonju University) ;
- Lee, Hyun Seo (Department of Healthcare & Science, Jeonju University) ;
- Ryu, Cheol (Hyangmiwon Corporation) ;
- Choi, Jiwon (Department of Radiological Sciences, Jeonju University) ;
-
Jang, Seon Il
(Ato Q&A Coperation)
- 조병옥 ((주)아토큐앤에이) ;
- 신재영 (전주대학교 보건관리학과) ;
- 데니스 (전주대학교 보건관리학과) ;
- 황영민 (전주대학교 보건관리학과) ;
- 이현서 (전주대학교 보건관리학과) ;
- 유철 ((주)향미원) ;
- 최지원 (전주대학교 방사선학과) ;
-
장선일
((주)아토큐앤에이)
- Received : 2016.10.04
- Accepted : 2016.12.04
- Published : 2016.12.31
Abstract
This study was conducted to evaluate the synergistic protective effects of mixtures of corn silk, perilla leaf and grape stem extract (CPG mixture) against UVB-induced skin damage and compound 48/80-induced pruritus in mice. The results showed that treatment with CPG mixture exhibited much stronger suppressive effect on erythema and melanin index as well as melanin formation than treatment with ascorbic acid (AA) in UVB-irradiated mice. Moreover, the treatment with CPG mixture showed ameliorative effect on immune cell infiltration and collagen fiber destruction in UV-irradiated mice. The treatment with CPG mixture inhibited glutathione (GSH) depletion, lipid peroxidation and production of pro-inflammatory cytokines in UVB-irradiated mice. Furthermore, the treatment with CPG mixture inhibited compound 48/80-induced scratching behavior and histological changes in mice. Taken together, these results indicated that CPG mixture has potentials as functional and therapeutic materials against skin damage and itch-related skin diseases.