Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Increment in vitamin D level and bone mineral accrual in children with vitamin D deficiency

  • Rao, Yashwant Kumar (Department of Pediatrics, Ganesh Shankar Vidyarthi Memorial Medical College) ;
  • Midha, Tanu (Department of Community Medicine, Government Medical College Kannauj) ;
  • Singh, Satyajeet (Department of Pediatrics, Ganesh Shankar Vidyarthi Memorial Medical College) ;
  • Bajpai, Anurag (Department of Pediatric Endocrinology, Regency Hospital) ;
  • Tilak, Amita (Department of Pharmacology, Ganesh Shankar Vidyarthi Memorial Medical College)
  • Received : 2016.02.03
  • Accepted : 2016.05.16
  • Published : 2016.07.15
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Abstract

Purpose: To compare different regimens of vitamin D with respect to its serum increment levels and bone mineral accrual in vitamin D-deficient children. Methods: Children identified as being vitamin D deficient (serum levels<20 ng/mL) were divided into 3 treatment groups by stratified block randomization (group 1, 4,000 IU/day of vitamin D3 plus 50 mg/kg/day calcium for 12 weeks; group 2, 30,000 IU/wk of vitamin D3 plus 50 mg/kg/day calcium for 12 weeks; and group 3, 300,000 IU of vitamin D3 once intramuscularly plus 50 mg/kg/day calcium). After regimen completion, each child received a maintenance dose of 400 IU/day vitamin D3 plus 50 mg/kg/day calcium. Their serum vitamin D level was measured after 3 and 12 months. Total body less head bone mineral concentration (BMC) and total body less head bone mineral density (BMD) were measured after 12 months. Results: The mean increment in serum vitamin D levels from baseline to 3 months was significantly higher in group 3 than in groups 1 and 2, but the levels from 3 to 12 months were almost similar among all 3 groups. There were no significant differences among the 3 groups with respect to percentage increase of BMD and BMC. Conclusion: The injectable form of vitamin D was more efficacious than the oral forms in increasing the serum level to the normal range. All 3 regimens were equally effective in increasing the BMC and BMD. The 400 IU/day maintenance dose was sufficient to keep the serum level within the normal range.

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References

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