Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Clinical importance of F-waves as a prognostic factor in Guillain-Barré syndrome in children

  • Lee, Eung-Bin (Department of Pediatrics, Yeungnam University College of Medicine) ;
  • Lee, Yun Young (Department of Pediatrics, Yeungnam University College of Medicine) ;
  • Lee, Jae Min (Department of Pediatrics, Yeungnam University College of Medicine) ;
  • Son, Su Min (Department of Physical Medicine and Rehabilitation, Yeungnam University College of Medicine) ;
  • Hwang, Su-Kyeong (Department of Pediatrics, Kyungpook National University Children's Hospital, Kyungpook National University School of Medicine) ;
  • Kwon, Soonhak (Department of Pediatrics, Kyungpook National University Children's Hospital, Kyungpook National University School of Medicine) ;
  • Kim, Sae Yoon (Department of Pediatrics, Yeungnam University College of Medicine)
  • Received : 2015.09.01
  • Accepted : 2015.11.09
  • Published : 2016.06.15
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Abstract

Purpose: A limited number of studies have examined the link between F-wave abnormalities and clinical presentation in pediatric Guillain-$Barr{\acute{e}}$ syndrome (GBS). Therefore, this study examined the importance of F-wave abnormalities as a prognostic factor in pediatric GBS patients. Methods: The records and electrodiagnostic studies (EDS) of 70 GBS patients were retrospectively evaluated, and divided into 2 groups according to the results of EDS. Group A (n=33) presented with F-wave abnormalities, and group B (n=26) exhibited normal findings. We compared laboratory reports, clinical features, response to treatment, and prognosis between the 2 groups. Results: Motor weakness was the most frequently observed symptom for either group. Clinically, the incidence of fever and upper respiratory symptoms differed between the 2 groups, while the prevalence of abnormal deep tendon reflex (DTR) was significantly higher in group A than B (P<0.05). Patients diagnosed with GBS had received intravenous immunoglobulin treatment: 94% in group A and 58% in group B. Furthermore, significantly greater numbers of patients in group A showed H-reflex abnormalities and poor prognosis compared with group B (P<0.05). Conclusion: This study demonstrated that F-waves are a clinically important prognostic factor in GBS. F-wave abnormalities were associated with abnormal DTR and poor prognosis in patients. Limited studies have examined the link between F-wave abnormalities and clinical results; therefore, further randomized controlled studies are needed to confirm the clinical characteristics and efficacy of treatments.

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