The Journal of Korean society of community based occupational therapy (대한지역사회작업치료학회지)

Korean Society of Community Based Occupational Therapy Association (대한지역사회작업치료학회)
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The Effect of Complex Exercise Program of Diabetic Rats with Ischemic Brain Injury Model

허혈성 뇌손상 모델 당뇨쥐의 복합운동프로그램의 효과

  • 김동현 (김천대학교 작업치료학과) ;
  • 방현수 (김천대학교 물리치료학과)
  • Received : 2016.05.31
  • Accepted : 2016.06.28
  • Published : 2016.06.30
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Abstract

Objective : We tried to know the improvement and neurological effect of diabetes when the complex exercise training was applied on diabetes that delayed the recovery of the ischemic brain injury. Methods : We performed this study in a animal lab which located in Gyengsangbukdo. We used 10 diabetes rats with ischemic brain injury, which is induced by STZ. We applied the complex exercise training on the rats for 4 weeks. We executed the maze test to confirm the recovery of the brain function and checked the blood sugar to know the improvement. Results : As a result of applying the complex exercise on diabetes rats with ischemic brain injury, there was a significant reduce of error and escape time in 3 weeks and 1 weeks, respectively. There was no difference of the blood sugar in control but there was a significant improvement in experiment group after applying the exercise training in 4 weeks. Conclusion : The senile disease like stroke and diabetes was increased currently. It is important for rehabilitation to improve the quality of life during the remainder of their life. In the study, we've known the improvement of diabetes and the recovery of the brain function when the complex exercise training was applied the rats with both diabetes and the ischemic brain injury.

목적 : 본 연구의 목적은 허혈성 뇌손상시 회복의 지연을 초래하는 당뇨에 복합운동프로그램을 적용하였을 때, 신경학적 효과와 당뇨의 개선효과를 확인하고자 하였다. 연구방법 : 본 연구는 경상북도 소재의 동물실험 연구실에서 실시하였고 허혈성 뇌손상 모델의 흰쥐에게 STZ(streptozotocin)를 투여하고 당뇨를 유발한 흰쥐 10마리를 사용하였다. 흰쥐에게는 4주간 복합운동프로그램을 실시하여 뇌기능회복을 확인하기 위해 미로검사(maze test)를 실시하였고, 당뇨의 개선효과를 보기위해서 혈당을 확인하였다. 결과 : 허혈성 뇌손상 모델 당뇨쥐에게 복합운동프로그램을 적용한 결과, 뇌기능회복을 확인하기 위한 미로검사에서는 실패횟수(error)가 3주 후부터 유의하게 감소하였고(p<.05) 탈출시간은 1주 후부터 유의하게 감소하였다(p<.05). 그리고 당뇨의 개선효과를 확인하기 위한 혈당 검사에서는 대조군에서는 유의한 변화가 없었고 복합운동프로그램을 적용한 실험군에서는 4주 후부터 유의한 효과가 있음을 알 수 있었다(p<.05). 결론 : 뇌졸중, 당뇨 등의 성인, 노인성 질환이 증가되고 있는 현 시점에서 환자들에게 재활은 여명수명동안 삶의 질 개선에 매우 중요하다. 본 연구는 허혈성 뇌졸중과 당뇨를 모두 가지고 있는 동물모델에게 치료사가 쉽게 시행할 수 있는 복합운동프로그램 적용을 통하여 뇌기능회복과 당뇨 개선효과를 확인할 수 있었다.

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