Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
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Oxidative Stress in the Heart of Rats Infected with Trypanosoma evansi

  • Baldissera, Matheus D. (Department of Microbiology and Parasitology, Universidade Federal de Santa Maria (UFSM)) ;
  • Souza, Carine de F. (Department of Pharmacology and Physiology, Universidade Federal de Santa Maria (UFSM)) ;
  • Bertoncheli, Claudia M. (Department of Microbiology and Parasitology, Universidade Federal de Santa Maria (UFSM)) ;
  • da Silveira, Karine L. (Department of Microbiology and Parasitology, Universidade Federal de Santa Maria (UFSM)) ;
  • Grando, Thirssa H. (Department of Microbiology and Parasitology, Universidade Federal de Santa Maria (UFSM)) ;
  • Porto, Bianca C.Z. (Department of Microbiology and Parasitology, Universidade Federal de Santa Maria (UFSM)) ;
  • Leal, Daniela B.R. (Department of Microbiology and Parasitology, Universidade Federal de Santa Maria (UFSM)) ;
  • Da Silva, Aleksandro S. (Department of Animal Science, Universidade do Estado de Santa Catarina (UDESC)) ;
  • Mendes, Ricardo E. (Section of Veterinary Pathology, Instituto Federal Catarinense (IFC)) ;
  • Stefani, Lenita M. (Department of Animal Science, Universidade do Estado de Santa Catarina (UDESC)) ;
  • Monteiro, Silvia G. (Department of Microbiology and Parasitology, Universidade Federal de Santa Maria (UFSM))
  • Received : 2015.06.02
  • Published : 2016.06.30
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Abstract

This study was conducted to investigate the occurrence of oxidative stress in the heart tissue of rats infected with Trypanosoma evansi. Rats were divided into 2 groups (A and B) with 12 animals each, and further subdivided into 4 subgroups (A1 and A2, 6 animals/each; and B1 and B2, 6 animals/each). Animals in the groups B1 and B2 were subcutaneously inoculated with T. evansi. Thiobarbituric acid reactive substances (TBARS), superoxide dismutase activity (SOD), glutathione S-transferase activity (GST), reduced glutathione activity (GSH), and non-protein thiols (NPSH) in the heart tissue were evaluated. At day 5 and 15 post-infection (PI), an increase in the TBARS levels and a decrease in the SOD activity (P<0.05) were observed. GSH and GST activities were decreased in infected animals at day 15 PI (P<0.05). Considering the proper functioning of the heart, it is possible that the changes in the activity of these enzymes involved in the oxidative stress may be related, at least in part, in the pathophysiology of rats infected with T. evansi.

Keywords

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