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Pulmonary epithelioid hemangioendothelioma misconceived as pulmonary metastasis of other malignancies

  • Noh, Gi Tark (Department of Internal Medicine, Bundang Jesaeng General Hospital) ;
  • Lee, Kyoung Ju (Department of Internal Medicine, Bundang Jesaeng General Hospital) ;
  • Sohn, Hee Jung (Department of Internal Medicine, Bundang Jesaeng General Hospital) ;
  • Lee, Kyung Han (Department of Internal Medicine, Bundang Jesaeng General Hospital) ;
  • Heo, Won Seok (Department of Internal Medicine, Bundang Jesaeng General Hospital) ;
  • Koh, Byung Sung (Department of Internal Medicine, Bundang Jesaeng General Hospital) ;
  • Han, Un Mi (Department of Pathology, Bundang Jesaeng General Hospital) ;
  • Bae, Young A (Department of Radiology, Bundang Jesaeng General Hospital)
  • 투고 : 2015.06.30
  • 심사 : 2015.08.28
  • 발행 : 2016.06.30

초록

Pulmonary epithelioid hemangioendothelioma (PEH) is a rare, low-to-intermediate malignant tumor of endothelial origin. Computed tomography (CT) findings of PEH demonstrate multiple small bilateral nodules; however, to the best of our knowledge, there were no reports on PEH coexisting with other malignancies. Here, we reported on a case involving PEH in a patient with colon cancer and breast cancer which was misconceived as pulmonary meta- stasis. A 63-year-old woman who suffered from constipation for 2 weeks visited our hospital. Colonoscopy showed a large mass with obstruction on hepatic flexure. The histological diagnosis was adenocarcinoma of the ascending colon. Multiple nodules in both lungs and breast were observed on a chest CT scan. A core biopsy of a breast nodule was performed and a diagnosis of invasive ductal carcinoma of the left breast was made. Pulmonary nodules observed on the chest CT scan was considered as pulmonary metastasis from colon or breast cancer. Laparoscopic right hemicolectomy was performed. At the same time, wedge resection of the lung was performed and pathological diagnosis was PEH. Radiologic features of PEH were difficult to distinguish from lung metastasis. Therefore the author reported a rare case involving PEH in a patient with primary malignancy of colon and breast.

키워드

참고문헌

  1. Travis WD, Tazelaar HD, Miettinen M. Epithelioid haemangioendothelioma/angiosarcoma. In: Travis WD, Brambilla E, Konrad Muller-Hermelink H, Harris CC, editors. World health organization classification of tumours: pathology and genetics of tumours of lung, pleura, thymus and heart. Lyon: IARC Press; 2004. p. 97-8.
  2. Amin RM, Hiroshima K, Kokubo T, Nishikawa M, Narita M, Kuroki M, et al. Risk factors and independent predictors of survival in patients with pulmonary epithelioid haemangioendothelioma. Review of the literature and a case report. Respirology 2006;11:818-25. https://doi.org/10.1111/j.1440-1843.2006.00923.x
  3. Dail D, Liebow A. Intravascular bronchioloalveolar tumor. Am J Pathol 1975;78:6a-7a.
  4. Weiss SW, Ishak KG, Dail DH, Sweet DE, Enzinger FM. Epithelioid hemangioendothelioma and related lesions. Semin Diagn Pathol 1986;3:259-87.
  5. Sardaro A, Bardoscia L, Petruzzelli MF, Portaluri M. Epithelioid hemangioendothelioma: an overview and update on a rare vascular tumor. Oncol Rev 2014;8:259.
  6. Mukundan G, Urban BA, Askin FB, Fishman EK. Pulmonary epithelioid hemangioendothelioma: atypical radiologic findings of a rare tumor with pathologic correlation. J Comput Assist Tomogr 2000;24:719-20. https://doi.org/10.1097/00004728-200009000-00009
  7. Okamura K, Ohshima T, Nakano R, Ouchi H, Takayama K, Nakanishi Y. A case of pulmonary epithelioid hemangioendothelioma surviving 10 years without treatment. Ann Thorac Cardiovasc Surg 2010;16:432-5.
  8. Yi L, Cheng D, Shi H, Zhang K, Liao Y, Ao Q, et al. Pulmonary epithelioid hemangioendothelioma coexisting with pulmonary nodular amyloidosis: case discussion and review of the literature. Int J Clin Exp Med 2014;7:1891-7.
  9. QHan KM, Kim DH, Myong NH. Fine needle aspiration cytology of pulmonary epithelioid hemangioendothelioma with prominent hyaline degeneration: a case report. Korean J Pathol 2010;44:554-7. https://doi.org/10.4132/KoreanJPathol.2010.44.5.554
  10. Ye B, Li W, Feng J, Shi JX, Chen Y, Han BH. Treatment of pulmonary epithelioid hemangioendothelioma with combination chemotherapy: report of three cases and review of the literature. Oncol Lett 2013;5:1491-6.
  11. Radzikowska E, Szczepulska-Wojcik E, Chabowski M, Oniszh K, Langfort R, Roszkowski K. Pulmonary epithelioid haemangioendothelioma--interferon 2-alpha treatment--case report. Pneumonol Alergol Pol 2008;76:281-5.
  12. Bagan P, Hassan M, Le Pimpec Barthes F, Peyrard S, Souilamas R, Danel C, et al. Prognostic factors and surgical indications of pulmonary epithelioid hemangioendothelioma: a review of the literature. Ann Thorac Surg 2006;82:2010-3.
  13. Ye B, Li W, Liu XY, Sun KL, Yang LH, Ma K, et al. Multiple organ metastases of pulmonary epithelioid haemangioendothelioma and a review of the literature. Med Oncol 2010;27:49-54. https://doi.org/10.1007/s12032-009-9169-0

피인용 문헌

  1. New Insights about Pulmonary Epithelioid Hemangioendothelioma: Review of the Literature and Two Case Reports vol.2017, pp.None, 2016, https://doi.org/10.1155/2017/5972940