Journal of the Korea Academia-Industrial cooperation Society (한국산학기술학회논문지)

The Korea Academia-Industrial cooperation Society (한국산학기술학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of Change in Body Mass Index on Change in Serum Total Cholesterol Levels among Industrial Workers

산업장 근로자들의 BMI 변화가 혈청총콜레스테롤의 변화에 미치는 영향

  • Yoon, Seok-Han (Department of Public Health, Graduate School of Chungnam National University) ;
  • Lee, Myung-Jun (Department of Public Health, Graduate School of Chungnam National University) ;
  • Cho, Young-Chae (Department of Preventive Medicine and Public Health, Chungnam National University School of Medicine)
  • 윤석한 (충남대학교 대학원 보건학과) ;
  • 이명준 (충남대학교 대학원 보건학과) ;
  • 조영채 (충남대학교 의학전문대학원 예방의학교실)
  • Received : 2016.03.08
  • Accepted : 2016.06.02
  • Published : 2016.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of this study is to investigate the association of total cholesterol levels (TC) and the incidence of hypercholesterolemia in response to changes in BMI. The subjects included a total of 28,249 industrial workers (25,548 male and 2,701 female) aged 30-69 years old who had received regular medical check-ups at least once per year from 2002 to 2012 (over 11 years). Data from this period were categorized into a first term (2002-2005), middle term (2006-2009), and last term (2010-2012). Then, the average TC was stratified by BMI, which was obtained from the initial examination results of each individual. In addition, average changes in TC were analyzed by stratifying with changes in BMI over 10 years (starting in 2002). The annual occurrence rates of hypercholesterolemia stratified by BMI were further assessed in patients with normal ranges of TC. In all three terms, the average TC was significantly elevated in the obese group ($25.0kg/m^2$) compared to the low weight group ($18.5kg/m^2$) and the normal weight group ($18.5-25.0kg/m^2$). Similarly, the group with higher BMI presented elevated rates of hypercholesterolemia compared to the groups with low BMI. In addition, increased BMI over the 10 year period significantly influenced TC. Consequently, it is suggested that evaluation and intervention for obesity control may be needed in order to manage the risk of high serum lipid levels.

본 연구의 목적은 근로자들의 BMI 변화에 따른 혈청총콜레스테롤의 변화 및 고콜레스테롤혈증 발생비율과의 관련성을 파악하고자 시도하였다. 연구는 2002년부터 20012년까지 11년간 각 연도별로 1회 이상 정기건강검진을 받았던 30~69세 근로자 28,249명(남자 25,548명, 여자 2,701명)을 대상으로 검진기간을 전기(2002-2005), 중기(2006-2009) 및 후기(2010-2012)로 구분하여 각 기간별 BMI 구분에 따른 혈청지질의 평균치를 분석하였다. 또한, 기준년도(2002)로부터 10년간의 BMI의 변화량 구분별로 혈청총콜레스테롤의 평균변화량을 산출하였으며, 혈청총콜레스테롤 정상자에서의 BMI 구분별 10년간의 고콜레스테롤혈증 발생의 년차별 비율을 분석하였다. 연구결과, 서로 다른 3시기(전기; 2002~2005, 중기; 2006~2009 및 후기; 2010~2012)에서의 평균혈청총콜레스테롤은 BMI가 낮은 군($18.5kg/m^2$미만군)에서 중간군($18.5-25.0kg/m^2$군), 높은 군($25.0kg/m^2$ 이상군)으로 갈수록 유의하게 증가하였으며, 고콜레스테롤혈증 발생비율도 BMI가 낮은 군에서 높은 군으로 갈수록 유의하게 증가하였다. 위와 같이 10년간의 BMI 변화량에 대한 혈청총콜레스테롤의 평균변화량의 경년적 추이를 볼 때, BMI의 증가는 혈청총콜레스테롤의 증가에 유의한 영향을 미치는 것으로 밝혀졌다. 따라서 혈청지질치의 위험 관리를 위해서는 비만관리에 대한 평가와 중재가 필요함을 시사하고 있다.

Keywords

References

  1. Hubert HB, Feinleib M, Mcnamara PM, Castelli WP. Obesity as an independent risk factor for cardiovascular disease: A 26-year follow up of participants in the Framingham Heart study. Circulation, 67:968-97, 1983. DOI: http://dx.doi.org/10.1161/01.CIR.67.5.968
  2. Kopelman. Obesity as a medical problem. Nature, 404:635-43, 2000. https://doi.org/10.1038/35007508
  3. Hsieh SD, Yoshinaga H. Abdominal fat distribution and coronary heart disease risk factors in men-wasit/height ratio as a simple and useful predictor. Int J Obes Relat Metab Disord. 19:585-589, 1995.
  4. Ko GTC, Chan JCN, Woo J, Lau E et al. Simple anthropometric indexes and cardiovascular risk factors in Chinese. Int J Obes Relat Metab Disord, 21:99, 1997. DOI: http://dx.doi.org/10.1038/sj.ijo.0800508
  5. Dyer AR, Stamler J, Shekelle RB. Relative weight and blood pressure in four Chicago epidemiologic studies. J Chronic Dis, 35:897-908, 1982. DOI: http://dx.doi.org/10.1016/0021-9681(82)90121-7
  6. Baumgartner RN, Roche AF, Chumlea WC. Fatness and far patterns: Associations with plasma lipids and blood pressures in adults, 18 to 57 years of age. Am J Epidemiol 126(4):614-628, 1987. https://doi.org/10.1093/oxfordjournals.aje.a114701
  7. Hartz AJ, Rupley DC, Kalkohoff RD. Relationship of obesity to diabetes: influence of obesity level and body fat distribution. Prev Med, 12:351-357, 1983. DOI: http://dx.doi.org/10.1016/0091-7435(83)90244-X
  8. Curb JD, Marcus EB. Body fat, coronary heart disease, and stroke in Japanese men. Am J Clin Nutr, 53:1612S-1615S, 1991. https://doi.org/10.1093/ajcn/53.6.1612S
  9. Chan JM, Rimm EB, Colditz GA. Obesity, fat distribution and weight gain as risk factors for clinical diabetes in men. Diabetes Care, 17:961-969, 1994. DOI: http://dx.doi.org/10.2337/diacare.17.9.961
  10. Lew EA, Garfinkel L. Variations in mortality by weight among 750,000 men and women. J Chronic Dis, 32:563-576, 1979. DOI: http://dx.doi.org/10.1016/0021-9681(79)90119-X
  11. Solomon CG, Manson JE. Obeity and mortality: review of the epidemiologic data. Am J Clin Nutr 66(4):1044S-1050S, 1997. https://doi.org/10.1093/ajcn/66.4.1044S
  12. Manson JE, Stampfer MJ, Hemmekens CH. body weight and longevity. A reassessment. JAMA, 257:353-358, 1987. DOI: http://dx.doi.org/10.1001/jama.257.3.353
  13. Yao C-H, Slattery MI, Jacobs DR. Anthropometric predictors of coronary heart disease and total mortality: findings from the US Railroad Study. Am J Epidemiol, 134:1278-1289, 1991. https://doi.org/10.1093/oxfordjournals.aje.a116031
  14. Ministry for Health Welfare and Family Affairs. Korea National Health and Nutrition Examination Survey - 2012, Ministry for Health Welfare and Family Affairs. 2013.
  15. Conner SL. The effect of age, body weight and family relationships on plasma lipoproteins and lipids in man, woman and children of randomly selected families. Circulation, 65:1290-1298, 1982. DOI: http://dx.doi.org/10.1161/01.CIR.65.7.1290
  16. Nakura I. Relationship between change in body mass index and blood pressure in urban residents. Japan J Public Health, 52(7):607-617, 2005.
  17. Park YJ, Lee WC, Yim HW, Park YM. The association between sleep and obesity in Korean adults. Korean J Prev Med, 40(6):454-460, 2007. DOI: http://dx.doi.org/10.3961/jpmph.2007.40.6.454
  18. Lee SH, Hwang JS, Park HS. Prediction of adolescence overweight from childhood body mass index-7 year retrospective study of suburban school children-. J Korean Acad Fam Med, 24:642-647, 2003.
  19. Lee SL, Lee KY, Park TJ, et al. The lifestyle associated with weight gain and persistent =ver weight for 2 years among hospital workers. J Korean Acad Fam Med, 26(11):680-685, 2005.
  20. Kim KB, Ji CA, Kim CS, et al. Lifestyle in relation to increase in weight in Korean middle-aged men, J Korean Acad Fam Med, 29:102-107, 2008.
  21. WHO. The Asia-Pacific Perspective: Redefining Obesity and Its Treatment. Sydney, Australia, Health Communications Australia Pty Ltd, 2000
  22. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension, 42(6):1206-1252, 2003. DOI: http://dx.doi.org/10.1161/01.HYP.0000107251.49515.c2
  23. Andrew LD, Robert JG, William BK. Incidence of hypertension in the Framingham study (Framingham offspring Study). Pre Med, 16:235-251, 1987. DOI: http://dx.doi.org/10.1016/0091-7435(87)90087-9
  24. Alan R, Dyer, Paul Elliott. On behalf of the INTERASALT Co-operative Research Group. The INTERSALT study: Relations of body mass index and blood pressure. J of Human Hypertension, 3:299-308, 1989.
  25. Mark LL, Adrienne C, William K, et al. Hihh-normal blood pressure progression to hypertension in the Framingham heart study. Hypertension, 17:22-27, 1991. DOI: http://dx.doi.org/10.1161/01.HYP.17.1.22
  26. Miura K. Predictors of the development of hypertension: ten year follow-up study in a community. Japan J Public Health, 39(8):456-465, 1992.
  27. Idzuno T, Yoshida K, Sugita M, et al. Significance of high normal blood pressure in occupational health care. Japan J Public Health, 43(1):3-8, 1996.
  28. Suka M, Sugimori H, Iida Y, Yoshida K. Risk factors for hypertension a longitudinal study of middle-aged Japanese male workers. Japanese J of Public Health, 48(7):543-550, 2001.
  29. Park KR, Cho YC. The association of blood pressures and blood biochemical properties with BMI in health checkup examinees. Journal of the Korea Academia-Industrial Cooperation Society, 12(7):3072-3081, 2011. DOI: http://dx.doi.org/10.5762/KAIS.2011.12.7.3072
  30. Sasaki M, Inagaki S, Fujii T, Toshinai K, Nakao C, Ueya E, Koseki S, Sato y, Haga S. Blood biochemical properties in male workers analysed according to body type. Japan Society for Occupational Health, 39:178-183, 1997.
  31. Fukui A. Relationship between obesity, total plasma cholesterol and blood pressure in male adults. Japan Soc Occup Health, 119-124, 2000. https://doi.org/10.1539/sangyoeisei.KJ00001991483
  32. Yamagishi K, Hosoda T, Sairenchi T, Mori K, Tomita H, Nishimura A, Tanigawa T, Iso H. Body mass index and subsequent risk of hypertension, diabetes and hypercholesterolemia in population-based sample of Japanese. Japan J Publ Health, 50(11):1050-1057, 2003.
  33. Ishikawa-Takata K, Ohta T, Moritaki K. Obesity, weight change, and risk for hypertension, diabetes, and hypercholesterolemia in Japanese men. Eur J Clin Nutr, 56:601-607, 2002. DOI: http://dx.doi.org/10.1038/sj.ejcn.1601364
  34. Huang Z, Walter CW, JoAnn EM, et al. Body weight, weight change, and risk for hypertension in women. Ann Intern Med, 12:81-87, 1998. DOI: http://dx.doi.org/10.7326/0003-4819-128-2-199801150-00001