Journal of Ginseng Research

  • 제40권3호
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  • Pages.245-250
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  • 2016
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  • 1226-8453(pISSN)
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  • 2093-4947(eISSN)
고려인삼학회 (The Korean Society of Ginseng)
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Complete 1H-NMR and 13C-NMR spectral assignment of five malonyl ginsenosides from the fresh flower buds of Panax ginseng

  • Wang, Yu-Shuai (Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences) ;
  • Jin, Yin-Ping (Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences) ;
  • Gao, Wei (Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences) ;
  • Xiao, Sheng-Yuan (Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences) ;
  • Zhang, Yu-Wei (Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences) ;
  • Zheng, Pei-He (Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences) ;
  • Wang, Jia (Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences) ;
  • Liu, Jun-Xia (Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences) ;
  • Sun, Cheng-He (Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences) ;
  • Wang, Ying-Ping (Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences)
  • 투고 : 2015.03.03
  • 심사 : 2015.08.06
  • 발행 : 2016.07.15
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초록

Background: Ginsenosides are the major effective ingredients responsible for the pharmacological effects of ginseng. Malonyl ginsenosides are natural ginsenosides that contain a malonyl group attached to a glucose unit of the corresponding neutral ginsenosides. Methods: Medium-pressure liquid chromatography and semipreparative high-performance liquid chromatography were used to isolate purified compounds and their structures determined by extensive one-dimensional- and two-dimensional nuclear magnetic resonance (NMR) experiments. Results: A new saponin, namely malonyl-ginsenoside Re, was isolated from the fresh flower buds of Panax ginseng, along with malonyl-ginsenosides Rb1, Rb2, Rc, Rd. Some assignments for previously published $^1H$- and $^{13}C$-NMR spectra were found to be inaccurate. Conclusion: This study reports the complete NMR assignment of malonyl-ginsenoside Re, $Rb_1$, $Rb_2$, Rc, and Rd for the first time.

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참고문헌

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  3. Malonylginsenosides with Potential Antidiabetic Activities from the Flower Buds of Panax ginseng vol.80, pp.4, 2017, https://doi.org/10.1021/acs.jnatprod.6b00789
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  6. Rb1, the Primary Active Ingredient in Panax ginseng C.A. Meyer, Exerts Antidepressant-Like Effects via the BDNF-Trkb-CREB Pathway vol.10, pp.None, 2016, https://doi.org/10.3389/fphar.2019.01034
  7. Memory enhancement of fresh ginseng on deficits induced by chronic restraint stress in mice vol.22, pp.4, 2016, https://doi.org/10.1080/1028415x.2017.1373928