Asian Pacific Journal of Cancer Prevention

  • 제17권4호
  • /
  • Pages.2321-2323
  • /
  • 2016
  • /
  • 1513-7368(pISSN)
  • /
  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Lack of Variation in Inflammatory Hematological Parameters between Benign Nodular Goiter and Papillary Thyroid Cancer

  • Yaylaci, Selcuk (Department of Internal Medicine, Sakarya University) ;
  • Tosun, Onder (Department of General Surgery, Findikli Goiter Research and Treatment Center, Sakarya University) ;
  • Sahin, Orhan (Department of General Surgery, Findikli Goiter Research and Treatment Center, Sakarya University) ;
  • Genc, Ahmet Bilal (Department of Internal Medicine, Medical Faculty, Sakarya University) ;
  • Aydin, Ercan (Department of Cardiology, Vakfikebir State Hospital) ;
  • Demiral, Gokhan (Department of General Surgery, Rize State Hospital) ;
  • Karahalil, Fatma (Department of Chemistry, Faculty of Arts and Sciences, Karadeniz Technical University) ;
  • Olt, Serdar (Department of Internal Medicine, Medical Faculty, Sakarya University) ;
  • Ergenc, Hasan (Department of Internal Medicine, Medical Faculty, Sakarya University) ;
  • Varim, Ceyhun (Department of Internal Medicine, Medical Faculty, Sakarya University)
  • 발행 : 2016.06.01
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초록

Background: Inflammatory hematological parameters like the neutrophil/lymphocyte (N/L) ratio have been investigated in many cancer types and significant relationships found with prognosis, for example. The aim of this present study was to investigate the impact of hematological parameters notably on N/L ratio and mean platelet volume (MPV) in papillary thyroid cancer cases. Materials and Methods: A total of 79 patients who underwent a thyroidectomy operation in Findikli, Goiter Research and Treatment Center during 2011-2015 period were enrolled in the study, 41 with papillary thyroid cancer and 38 with benign goiter confirmed by pathological examination. We collected clinical and laboratory data for the patients from hospital records retrospectively. Blood samples taken at admission were assessed for parameters compared between the groups. Results: No significant differences between papillary thyroid cancer and benign goiter groups were apparent in terms of age, the N/L ratio, MPV, white blood cell count (WBC), red blood cell count (RBC), hemoglobin, hematocrit, platelet, neutrophil, lymphocyte, red blood cell distribution width (RDW) and platelet crit (PCT) levels (p>0.05). Only the level of platelet distribution width (PDW) significantly differed, being lower in the papillary cancer group (p<0.05). Conclusions: No significant relationship between papillary thyroid cancer and inflammatory hematological parameters including in particular the N/L ratio and MPV. The relevance of the PDW values remains unclear.

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참고문헌

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  2. Trends in white blood cell and platelet indices in a comparison of patients with papillary thyroid carcinoma and multinodular goiter do not permit differentiation between the conditions vol.42, pp.4, 2017, https://doi.org/10.1080/07435800.2017.1319859
  3. Platelet distribution width correlates with prognosis of non-small cell lung cancer vol.7, pp.1, 2017, https://doi.org/10.1038/s41598-017-03772-z
  4. Evaluation of Hemocytometer Parameters as Potential Biomarkers in Benign Multinodular Goiter and Papillary Thyroid Carcinoma vol.19, pp.12, 2017, https://doi.org/10.5812/ircmj.58295
  5. Diagnostic Accuracy of Preoperative Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Detecting Occult Papillary Thyroid Microcarcinomas in Benign Multinodular Goitres vol.2018, pp.2042-0072, 2018, https://doi.org/10.1155/2018/3470429
  6. Different prognostic values of individual hematologic parameters in papillary thyroid cancer due to age-related changes in immunity vol.96, pp.2, 2019, https://doi.org/10.4174/astr.2019.96.2.70