Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Premature Ejaculation and Erectile Dysfunction in Iranian Prostate Cancer Patients

  • Lin, Chung-Ying (Department of Public Health, College of Medicine, National Cheng Kung University, Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University) ;
  • Burri, Andrea (Department of Psychology, University of Zurich) ;
  • Pakpour, Amir H (Social Determinants of Health Research Center (SDH), Qazvin University of Medical Sciences)
  • Published : 2016.06.01
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Abstract

Background: To investigate the prevalence of premature ejaculation (PE) and erectile dysfunction (ED) in a sample of patients with prostate cancer and to determine the utility of the previously suggested cutoffs of the Premature Ejaculation Diagnostic Tool (PEDT) for the diagnosis of PE and that of International Index of Erectile Function (IIEF-5) for ED. Materials and Methods: A total of 1,202 men with prostate cancer were invited from urology clinics at the universities of Iran, Tehran, Qazvin, Ahvaz, Guilan and Tabriz. Clinical characteristics were collected through medical records. PE and ED diagnoses were made by trained urologists. In addition to the clinical diagnoses, PE and ED were measured through self-report using the PEDT and the IIEF-5. Questionnaire cutoff scores were determined using receiver operating characteristic (ROC) curves and confirmed by predictive ability using logistic regression. Results: The prevalence of PE was 63.7% and that of ED was 66.2%. Prevalences of PE decreased and that of ED increased with advanced TNM stages. According to ROC, the suggested cutoff for the PEDT to diagnose a PE was ${\geq}11$ (sensitivity=0.988, 1-specificity=0.084, and predictive ability=0.914) and ${\leq}17$ for the IIEF-5 (sensitivity=0.966, 1-specificity=0.031, and predictive ability=0.967). Conclusions: Prevalence of sexual problems was high in prostate cancer patients in Iran, therefore oncologists should take into account these potential problems when deciding on treatment modalities.

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References

  1. Aus G, Abbou CC, Bolla M, et al (2005). EAU guidelines on prostate cancer. Eur Urol, 48, 546-51. https://doi.org/10.1016/j.eururo.2005.06.001
  2. Beard CJ, Lamb C, Buswell L, et al (1998). Radiation-associated morbidity in patients undergoing small-field external beam irradiation for prostate cancer. Int J Radiat Oncol Biol Phys, 41, 257-62. https://doi.org/10.1016/S0360-3016(98)00054-6
  3. Benson CR, Serefoglu EC, Hellstrom WJ (2012). Sexual dysfunction following radical prostatectomy. J Androl, 33, 1143-54. https://doi.org/10.2164/jandrol.112.016790
  4. Bianco FJ, McHone BR, Wagner K, et al (2009). Prevalence of erectile dysfunction in men screened for prostate cancer. Urol, 74, 89-93. https://doi.org/10.1016/j.urology.2008.03.036
  5. Bodie J, Lewis J, Schow D, et al (2003). Laboratory evaluations of erectile dysfunction: an evidence based approach. J Urol, 169, 2262-4 https://doi.org/10.1097/01.ju.0000063940.19080.58
  6. Bortolotti A, Fedele D, Chatenoud L, et al (2001). Cigarette smoking: a risk factor for erectile dysfunction in diabetics. Eur Urol, 40, 392-6. https://doi.org/10.1159/000049805
  7. Chen RC, Vetter RJ, Lukka H, et al (2014). Recommended patient-reported core set of symptoms to measure in prostate cancer treatment trials. J Natl Cancer Inst, 106, 132. https://doi.org/10.1093/jnci/dju132
  8. Choo R, Long J, Gray R, et al (2010). Prospective survey of sexual function among patients with clinically localized prostate cancer referred for definitive radiotherapy and the impact of radiotherapy on sexual function. Support Care Cancer,18, 715-22.
  9. Chew KK, Bremner A, Stuckey B, et al (2009). Is the relationship between cigarette smoking and male erectile dysfunction independent of cardiovascular disease? Findings from a population-based cross-sectional study. J Sex Med, 6, 222-31. https://doi.org/10.1111/j.1743-6109.2008.00971.x
  10. Dubbelman YD, Dohle GR, Schröder FH (2006). Sexual function before and after radical retropubic prostatectomy: a system review of prognostic indicators for a successful outcome. Eur Urol, 50, 711-18. https://doi.org/10.1016/j.eururo.2006.06.009
  11. DSM-5: Diagnostic and Statistical Manual of Mental Disorders (5th ed.). Washington (DC): American Psychiatric Association; 2013
  12. Diagnostic and statistical manual of mental disorders, fourth edition, text revision: DSM-IV-TR. Washington (DC): American Psychiatric Association; 2000.
  13. Fan J, Upadhye S, Worster A (2006). Understanding receiver operating characteristic (ROC) curves. CJEM 2006,8,19-20.
  14. Gallo L, Perdona S, Gallo A (2010). The role of short frenulum and the effects of frenulectomy on premature ejaculation. J Sex Med, 7, 1269-76. https://doi.org/10.1111/j.1743-6109.2009.01661.x
  15. Gagnon DD, Polverejan E (2008). Premature Ejaculation: results from a five-country European observational study. Eur Urol, 53, 1048-57. https://doi.org/10.1016/j.eururo.2007.10.015
  16. Giuliano F, Patrick DL, Porst H, et al (2014). Female partner's perception of premature ejaculation and its impact on relationship breakups, relationship quality, and sexual satisfaction. J Sex Med, 11, 2243-55. https://doi.org/10.1111/jsm.12551
  17. Incrocci L, Slob AK, Levendag PC (2002). Sexual (dys)function after radiotherapy for prostate cancer: a review. Int J Radiat Oncol Biol Phys, 52, 681-93. https://doi.org/10.1016/S0360-3016(01)02727-4
  18. Ong WL, McLachlan H, Millar JL (2015). Prevalence of baseline erectile dysfunction (ED) in an Australian cohort of men with localized prostate cancer. J Sex Med, 12, 1267-74. https://doi.org/10.1111/jsm.12867
  19. Pakpour AH, Yekaninejad MS, Nikoobakht MR, et al (2014). Psychometric properties of the Iranian version of the Premature Ejaculation Diagnostic Tool. Sex Med, 2, 31-40. https://doi.org/10.1002/sm2.21
  20. Pakpour AH, Zeidi IM, Yekaninejad MS, et al (2014). Validation of a translated and culturally adapted Iranian version of the International Index of Erectile Function. J Sex Marital Ther, 40, 541-51. https://doi.org/10.1080/0092623X.2013.788110
  21. Rosen RC, Cappelleri JC, Smith MD et al (1999). Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res, 11, 319-26. https://doi.org/10.1038/sj.ijir.3900472
  22. Saitz TR, Serefoglu EC, Trost LW et al (2013). The pre-treatment prevalence and types of sexual dysfunction among patients diagnosed with prostate cancer. Androl, 1, 859-63. https://doi.org/10.1111/j.2047-2927.2013.00137.x
  23. Spector IP, Carey MP (1990). Incidence and prevalence of sexual dysfunctions: a critical review of the empirical literature. Arch Sex Behav, 19, 389-408. https://doi.org/10.1007/BF01541933
  24. Singer PA, Tasch ES, Stocking C, et al (1991). Sex or survival: tradeoffs between quality and quantity of life. J Clin Oncol, 9, 328-34. https://doi.org/10.1200/JCO.1991.9.2.328
  25. Symonds T, Perelman MA, Althof S, et al (2007). Development and validation of a premature ejaculation diagnostic tool. Eur Urol, 52, 565-73. https://doi.org/10.1016/j.eururo.2007.01.028
  26. Waldinger MD, Zwinderman AH, Schweitzer DH, et al (2004). Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis. Int J Impot Res, 16, 369-81. https://doi.org/10.1038/sj.ijir.3901172
  27. Walz J, Perrotte P, Suardi N, et al (2008). Baseline prevalence of erectile dysfunction in a prostate cancer screening population. J Sex Med, 5, 428-35. https://doi.org/10.1111/j.1743-6109.2007.00662.x