한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제33권3호
  • /
  • Pages.155-159
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  • 2016
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
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Recombinant Tissue Plasminogen Activator Therapy for Aortic Thromboembolism in Four Dogs

  • Han, Sei-Myoung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University) ;
  • Lee, Ji-Ye (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University) ;
  • Kweon, Kyeong (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University) ;
  • Choi, Min-Cheol (Department of Veterinary Medical Imaging, College of Veterinary Medicine, Seoul National University) ;
  • Yoon, Jung-Hee (Department of Veterinary Medical Imaging, College of Veterinary Medicine, Seoul National University) ;
  • Youn, Hwa-Young (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University)
  • 투고 : 2015.09.10
  • 심사 : 2016.05.17
  • 발행 : 2016.06.30
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초록

Four dogs were brought to the Veterinary Medicine Teaching Hospital of Seoul National University (VMTH SNU) with a history of hind limb ataxia, three with pain, one without pain. Three of the four showed weak to absent femoral pulses and cold extremities. Thromboembolism was identified by ultrasonography in the external and/or internal iliac arteries. A thrombolytic agent, recombinant tissue plasminogen activator (rt-PA), was administered (0.5-1 mg/kg, every 60-120 min, 3-5 doses). Two dogs (Cases 2 and 3), which were instantly provided rt-PA treatment, survived 6 and 17 months, respectively, although hematemesis and hematochezia were observed during treatment. In the other two dogs (Cases 1 and 4), rt-PA was administered 4 and 28 days after the appearance of pelvic limb symptoms, which may have limited the benefits of the treatment. When rt-PA treatment is instituted instantly and the side effects are monitored thoroughly during treatment, a good prognosis might be expected in canine aortic thromboembolism. For this reason, we suggest that rt-PA treatment should be initiated immediately if thromboembolism is identified.

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참고문헌

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