Journal of the East Asian Society of Dietary Life (동아시아식생활학회지)

The East Asian Society of Dietary Life (동아시아식생활학회)
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Inhibitory Effects of Anthocyanin-rich Fraction from Purple Sweet Potato on High Fat Diet-induced Insulin Resistance and Hepatic Steatosis

자색고구마로부터 분리한 안토시아닌 분획물의 고지방식이로 유도된 인슐린 저항성과 간 지질 축적 개선 효과

  • Nam, Song Yee (Functional Food & Nutrition Division, Department of Agrofood Resources, National Institute of Agricultural Science) ;
  • Jang, Hwan Hee (Functional Food & Nutrition Division, Department of Agrofood Resources, National Institute of Agricultural Science) ;
  • Kim, Jung Bong (Functional Food & Nutrition Division, Department of Agrofood Resources, National Institute of Agricultural Science) ;
  • Lee, Sung Hyun (Functional Food & Nutrition Division, Department of Agrofood Resources, National Institute of Agricultural Science) ;
  • Lee, Young Min (Major of Food & Nutrition, Division of Applied Food System, Seoul Women's University)
  • 남송이 (국립농업과학원 기능성식품과) ;
  • 장환희 (국립농업과학원 기능성식품과) ;
  • 김정봉 (국립농업과학원 기능성식품과) ;
  • 이성현 (국립농업과학원 기능성식품과) ;
  • 이영민 (서울여자대학교 식품영양학과)
  • Received : 2016.05.30
  • Accepted : 2016.06.23
  • Published : 2016.06.30
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Abstract

Anthocyanins, a class of flavonoids, are natural water-soluble pigments, mainly found in vegetables and fruits. Anthocyanins have attractive pharmacological activities, such as anti-oxidant, anti-inflammatory, anti-cancer, and anti-diabetic effects. The purpose of this study was to investigate the inhibitory effects of the anthocyanin-rich fraction (ANF) from purple sweet potato on high fat diet-induced insulin resistance and hepatic steatosis. C57BL/6J mice were assigned to the following groups (n=8 per group): normal fat diet (NF); high fat diet (HF); high fat diet with ANF 50mg/kg (ANF50). Normal fat or high fat diets were fed for a total of 17 weeks, and ANF was orally administrated for 8 weeks (from 10 to 17 weeks, five times/week). In our results, there were no significant differences in body weight, food intake, and tissue weight upon ANF supplementation. The levels of serum triacylglycerol, total-cholesterol, and glucose were also not affected by ANF supplementation. However, ANF supplementation significantly decreased serum insulin and HOMA-IR levels as well as prevented hepatic fat accumulation in high fat-fed mice. These results show that ANF may be beneficial for improving high fat-induced insulin resistance and protecting against development of hepatic steatosis.

Keywords

References

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