생약학회지 (Korean Journal of Pharmacognosy)

  • 제47권2호
  • /
  • Pages.192-196
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  • 2016
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  • 0253-3073(pISSN)
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  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

기체크로마토그래피에 의한 한국산 배초향의 정유 분석과 Cholinesterase 억제활성

Gas Chromatographic Analysis and Cholinesterase Activity of the Essential Oil from Korean Agastache rugosa

  • Choi, Jae Sue (Department of Food Science and Nutrition, Pukyong National University) ;
  • Song, Byong-Min (Department of Forest Science, Sangji University) ;
  • Park, Hee-Juhn (Deaprtment of Pharmaceutical Engineering, Sangji University)
  • 투고 : 2016.05.20
  • 심사 : 2016.06.17
  • 발행 : 2016.06.30
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초록

The herb of Agastache rugosa (Lamiaceae) called Korean mint as a spice or Agastache Herba as a crude drug is known to contain highly fragrant volatile substances. This research aimed to establish the quantitative gas chromatography (GC) method on the essential oil of A. rugosa using the three standard compounds, estragole, methyleugenol, pulegone, and to find whether the essential oil has anti-Alzheimer's activity. The GC quantification method was established by determining the linearity of calibration curve ($R^2$), linear range, and both limit-of-detection (LOD) and limit-of-quantification (LOQ). The $IC_{50}$ of the essential oil on the activities of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were determined to be $69.06{\pm}0.26$ and $76.71{\pm}0.58{\mu}g/ml$, respectively.

키워드

참고문헌

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