Asian-Australasian Journal of Animal Sciences

  • 제29권7호
  • /
  • Pages.1044-1051
  • /
  • 2016
  • /
  • 1011-2367(pISSN)
  • /
  • 1976-5517(eISSN)
아세아태평양축산학회 (Asian Australasian Association of Animal Production Societies)
권호 표지
DOI QR코드

DOI QR Code

Identification of Molecular Signatures from Different Vaccine Adjuvants in Chicken by Integrative Analysis of Microarray Data

  • 투고 : 2014.12.08
  • 심사 : 2015.02.11
  • 발행 : 2016.07.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The present study compared the differential functions of two groups of adjuvants, Montanide incomplete Seppic adjuvant (ISA) series and Quil A, cholesterol, dimethyl dioctadecyl ammonium bromide, and Carbopol (QCDC) formulations, in chicken by analyzing published microarray data associated with each type of vaccine adjuvants. In the biological function analysis for differentially expressed genes altered by two different adjuvant groups, ISA series and QCDC formulations showed differential effects when chickens were immunized with a recombinant immunogenic protein of Eimeria. Among the biological functions, six categories were modified in both adjuvant types. However, with respect to "Response to stimulus", no biological process was modified by the two adjuvant groups at the same time. The QCDC adjuvants showed effects on the biological processes (BPs) including the innate immune response and the immune response to the external stimulus such as toxin and bacterium, while the ISA adjuvants modified the BPs to regulate cell movement and the response to stress. In pathway analysis, ISA adjuvants altered the genes involved in the functions related with cell junctions and the elimination of exogenous and endogenous macromolecules. The analysis in the present study could contribute to the development of precise adjuvants based on molecular signatures related with their immunological functions.

키워드

참고문헌

  1. Anderson, A. J. 1970. Lysosomal enzyme activity in rats with adjuvant-induced arthritis. Ann. Rheum. Dis. 29:307-13. https://doi.org/10.1136/ard.29.3.307
  2. Aucouturier, J., S. Ascarateil, and L. Dupuis. 2006. The use of oil adjuvants in therapeutic vaccines. Vaccine 24 (Suppl 2):S44-S45. https://doi.org/10.1016/j.vaccine.2005.01.116
  3. Baldridge, J. R. and J. R. Ward. 1997. Effective adjuvants for the induction of antigen-specific delayed-type hypersensitivity. Vaccine 15:395-401. https://doi.org/10.1016/S0264-410X(96)00199-5
  4. Bowersock, T. L. and S. Martin. 1999. Vaccine delivery to animals. Adv. Drug Deliv. Rev. 38:167-194. https://doi.org/10.1016/S0169-409X(99)00015-0
  5. Cox, J. C. and A. R. Coulter. 1997. Adjuvants-A classification and review of their modes of action. Vaccine 15:248-256. https://doi.org/10.1016/S0264-410X(96)00183-1
  6. Cox, S. J., N. Aggarwal, R. J. Statham, and P. V. Barnett. 2003. Longevity of antibody and cytokine responses following vaccination with high potency emergency FMD vaccines. Vaccine 21:1336-1347. https://doi.org/10.1016/S0264-410X(02)00691-6
  7. Crawford, J. M. and K. Watanabe. 1994. Cell adhesion molecules in inflammation and immunity: Relevance to periodontal diseases. Crit. Rev. Oral Biol. Med. 5:91-123. https://doi.org/10.1177/10454411940050020301
  8. Davidsen, J., I. Rosenkrands, D. Christensen, A. Vangala, D. Kirby, Y. Perrie, E. M. Agger, and P. Andersen. 2005. Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6'-dibehenate)-a novel adjuvant inducing both strong CMI and antibody responses. Biochim. Biophys. Acta Biomembranes 1718:22-31. https://doi.org/10.1016/j.bbamem.2005.10.011
  9. Dominowski, P. J., R. M. Mannan, R. L. Krebs, J. R. Thompson, T. A. Childers, M. K. Olsen, J. R. J. Yancey, R. Weeratna, S. Zhang, and C. M. Bagi. 2009. Novel adjuvant compositions. US 2009/0324641 A1. Pfizer Inc., New York, NY , USA.
  10. Drane, D., C. Gittleson, J. Boyle, and E. Maraskovsky. 2007. ISCOMATRIX adjuvant for prophylactic and therapeutic vaccines. Expert Rev. Vaccines 6:761-772. https://doi.org/10.1586/14760584.6.5.761
  11. Dupuis, L., S. Ascarateil, J. Aucouturier, and V. Ganne. 2006. SEPPIC vaccine adjuvants for poultry. Ann. NY Acad. Sci. 1081:202-205. https://doi.org/10.1196/annals.1373.024
  12. Geetha, T. and P. Varalakshmi. 1999. Effect of lupeol and lupeol linoleate on lysosomal enzymes and collagen in adjuvant-induced arthritis in rats. Mol. Cell. Biochem. 201:83-87. https://doi.org/10.1023/A:1007056300503
  13. Gupta, R. K. and G. R. Siber. 1995. Adjuvants for human vaccines-current status, problems and future prospects. Vaccine 13:1263-1276. https://doi.org/10.1016/0264-410X(95)00011-O
  14. Jang, S. I., D. K. Kim, H. S. Lillehoj, S. H. Lee, K. W. Lee, F. Bertrand, L. Dupuis, S. Deville, J. Ben Arous, and E. P. Lillehoj. 2013. Evaluation of Montanide ISA 71 VG adjuvant during profilin vaccination against experimental coccidiosis. PLoS One 8(4):e59786. https://doi.org/10.1371/journal.pone.0059786
  15. Jang, S. I., H. S. Lillehoj, S. H. Lee, K. W. Lee, E. P. Lillehoj, F. Bertrand, L. Dupuis, and S. Deville. 2011. Mucosal immunity against Eimeria acervulina infection in broiler chickens following oral immunization with profilin in Montanide adjuvants. Exp. Parasitol. 129:36-41. https://doi.org/10.1016/j.exppara.2011.05.021
  16. Jang, S. I., H. S. Lillehoj, S. H. Lee, K. W. Lee, M. S. Park, G. R. Bauchan, E. P. Lillehoj, F. Bertrand, L. Dupuis, and S. Deville. 2010. Immunoenhancing effects of Montanide ISA oil-based adjuvants on recombinant coccidia antigen vaccination against Eimeria acervulina infection. Vet. Parasitol. 172:221-228. https://doi.org/10.1016/j.vetpar.2010.04.042
  17. Johnston, B. A., H. Eisen, and D. Fry. 1991. An evaluation of several adjuvant emulsion regimens for the production of polyclonal antisera in rabbits. Lab. Anim. Sci. 41:15-21.
  18. Kim, D. K., H. S. Lillehoj, S. H. Lee, P. Dominowski, R. J. Yancey, and E. P. Lillehoj. 2012. Effects of novel vaccine/adjuvant complexes on the protective immunity against Eimeria acervulina and transcriptome profiles. Avian Dis. 56:97-109. https://doi.org/10.1637/9720-031711-Reg.1
  19. Kumar, V. L. and S. Roy. 2007. Calotropis procera latex extract affords protection against inflammation and oxidative stress in Freund's complete adjuvant-induced monoarthritis in rats. Mediators Inflamm. Article ID 47523.
  20. Leclerc, C. 2003. New approaches in vaccine development. Comp. Immunol. Microbiol. Infect. Dis. 26:329-341. https://doi.org/10.1016/S0147-9571(03)00018-3
  21. Lee, K. W., H. S. Lillehoj, S. H. Lee, S. I. Jang, G. D. Ritter, D. A. Bautista, and E. P. Lillehoj. 2011. Impact of fresh or used litter on the posthatch immune system of commercial broilers. Avian Dis. 55:539-544. https://doi.org/10.1637/9695-022511-Reg.1
  22. Leenaars, P. P. A. M., C. F. M. Hendriksen, A. F. Angulo, M. A. Koedam, and E. Claassen. 1994. Evaluation of several adjuvants as alternatives to the use of Freund's adjuvant in rabbits. Vet. Immunol. Immunopathol. 40:225-241. https://doi.org/10.1016/0165-2427(94)90022-1
  23. Leenaars, P. P., C. F. Hendriksen, M. A. Koedam, I. Claassen, and E. Claassen. 1995. Comparison of adjuvants for immune potentiating properties and side effects in mice. Vet. Immunol. Immunopathol. 48:123-138. https://doi.org/10.1016/0165-2427(94)05413-M
  24. Leenaars, P. P., M. A. Koedam, P. W. Wester, V. Baumans, E. Claassen, and C. F. Hendriksen. 1998. Assessment of side effects induced by injection of different adjuvant/antigen combinations in rabbits and mice. Lab. Anim. 32:387-406. https://doi.org/10.1258/002367798780599884
  25. Lillehoj, E. P., C. H. Yun, and H. S. Lillehoj. 2000a. Vaccines against the avian enteropathogens Eimeria, Cryptosporidium, and Salmonella. Anim. Health Res. Rev. 1:47-65. https://doi.org/10.1017/S1466252300000050
  26. Lillehoj, H. S., K. D. Choi, M. C. Jenkins, V. N. Vakharia, K. D. Song, J. Y. Han, and E. P. Lillehoj. 2000b. A recombinant Eimeria protein inducing interferon-gamma production: Comparison of different gene expression systems and immunization strategies for vaccination against coccidiosis. Avian Dis. 44:379-389. https://doi.org/10.2307/1592553
  27. Newman, M. J. and M. F. Powell. 1995. Immunological and formulation design considerations for subunit vaccines. Pharm. Biotechnol. 6:1-42. https://doi.org/10.1007/978-1-4615-1823-5_1
  28. Nigrovic, P. A. and D. M. Lee. 2005. Mast cells in inflammatory arthritis. Arthritis Res. Ther. 7:1-11. https://doi.org/10.1186/ar1446
  29. Reddy, G. K. and S. C. Dhar. 1988. Studies on carbohydrate moieties of glycoproteins in established adjuvant induced arthritis. Agents Actions 25:63-70. https://doi.org/10.1007/BF01969096
  30. Reed, S. G., S. Bertholet, R. N. Coler, and M. Friede. 2009. New horizons in adjuvants for vaccine development. Trends Immunol. 30:23-32. https://doi.org/10.1016/j.it.2008.09.006
  31. Richards, R. L., C. R. Alving, and N. M. Wassef. 1996. Liposomal subunit vaccines: Effects of lipid A and aluminum hydroxide on immunogenicity. J. Pharm. Sci 85:1286-1289. https://doi.org/10.1021/js9601593
  32. Ritchie, M. E., J. Silver, A. Oshlack, M. Holmes, D. Diyagama, A. Holloway, and G. K. Smyth. 2007. A comparison of background correction methods for two-colour microarrays. Bioinformatics 23:2700-2707. https://doi.org/10.1093/bioinformatics/btm412
  33. Shirley, M. W. and H. S. Lillehoj. 2012. The long view: A selective review of 40 years of coccidiosis research. Avian Pathol. 41:111-121. https://doi.org/10.1080/03079457.2012.666338
  34. Stahl, P. D. and R. A. B. Ezekowitz. 1998. The mannose receptor is a pattern recognition receptor involved in host defense. Curr. Opin. Immunol. 10:50-55. https://doi.org/10.1016/S0952-7915(98)80031-9
  35. Yamada, K., T. Nakamura, and H. Utsumi. 2006. Enhanced intraarticular free radical reactions in adjuvant arthritis rats. Free Radic. Res. 40:455-460. https://doi.org/10.1080/10715760500440536
  36. Yang, Y. W., C. A. Wu, and W. J. W. Morrow. 2004. Cell death induced by vaccine adjuvants containing surfactants. Vaccine 22:1524-1536. https://doi.org/10.1016/j.vaccine.2003.08.048
  37. Yarovinsky, F., D. Zhang, J. F. Andersen, G. L. Bannenberg, C. N. Serhan, M. S. Hayden, S. Hieny, F. S. Sutterwala, R. A. Flavell, S. Ghosh, and A. Sher. 2005. TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science 308:1626-1629. https://doi.org/10.1126/science.1109893
  38. Yeatman, T. J. 2004. A renaissance for SRC. Nat. Rev. Cancer 4:470-480. https://doi.org/10.1038/nrc1366
  39. Zamze, S., L. Martinez-Pomares, H. Jones, P. R. Taylor, R. J. Stillion, S. Gordon, and S. Y. C. Wong. 2002. Recognition of bacterial capsular polysaccharides and lipopolysaccharides by the macrophage mannose receptor. J. Biol. Chem. 277:41613-41623. https://doi.org/10.1074/jbc.M207057200