Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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Administration and Efficiency Comparison of Chloral Hydrate during Pediatric Sedation

소아 진정시 사용하는 포크랄 약물의 투여 방법 및 효율성 비교

  • Bae, Jung Ah (Department of Emergency Medicine, Ewha University) ;
  • Choi, Yoon Hee (Department of Emergency Medicine, Ewha University) ;
  • Kim, Ah Jin (Department of Emergency Medicine, School of Medicine, Inha University) ;
  • Lee, Sun Hwa (Department of Emergency Medicine, Inje University Sanggyepaik Hospital)
  • 배정아 (이화여자대학교 응급의학교실) ;
  • 최윤희 (이화여자대학교 응급의학교실) ;
  • 김아진 (인하대학교 의과대학 응급의학교실) ;
  • 이선화 (인제대학교 상계백병원 응급의학교실)
  • Received : 2016.05.04
  • Accepted : 2016.05.12
  • Published : 2016.06.30
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Abstract

Purpose: In most emergency department (ED), sedation is required before carrying out an invasive procedure on a pediatric patient. In the ED setting, it is essential to determine the optimal dose and administration route of CH for successful sedation. The aim of this study was to determine the optimal dose of CH for an invasive procedure and to examine the effectiveness of the drug's different administration routes. Furthermore, in this study, we performed simple survey using questionnaire which composed of Likert-scale to evaluate satisfaction of medical staffs in ED with administration routes. Methods: This study was conducted prospectively. The study participants were pediatric patients under 8 years old who visited the ED in two tertiary hospitals in South Korea within a period of 12 months. Results: Overall, 300 patients were included in this study. The age, sex, and weight of the patients were not shown to influence the sedation time. Chloral hydrate dosage is the independent factor to influence the both sedation and discharge time (p<0.01). In the comparison of the groups, groups 1, 2, and 5 showed no significant difference. On the other hand, groups 3 and 4 were shown to be statistically significantly different from group 1. Conclusion: Up to 100 mg/kg CH is safe to use in the emergency department for pediatric patients, but the initial dose of 50 mg/kg for oral administration should be considered in advance because it can provide safe and effective sedation with a lower possibility of causing an adverse effect.

Keywords

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