Biomaterials Research (생체재료학회지)

Korean Society for Biomaterials (한국생체재료학회)
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Collagen-grafted porous HDPE/PEAA scaffolds for bone reconstruction

  • Kim, Chang-Shik (Department of Polymer Science and Engineering, Kyungpook National University) ;
  • Jung, Kyung-Hye (Department of Advanced Materials and Chemical Engineering, Catholic University of Daegu) ;
  • Kim, Hun (Jeil Medical Corporation) ;
  • Kim, Chan-Bong (Jeil Medical Corporation) ;
  • Kang, Inn-Kyu (Department of Polymer Science and Engineering, Kyungpook National University)
  • Received : 2016.04.29
  • Accepted : 2016.07.19
  • Published : 2016.09.01
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Abstract

After tumor resection, bone reconstruction such as skull base reconstruction using interconnected porous structure is absolutely necessary. In this study, porous scaffolds for bone reconstruction were prepared using heat-pressing and salt-leaching methods. High-density polyethylene (HDPE) and poly(ethylene-co-acrylic acid) (PEAA) were chosen as the polymer composites for producing a porous scaffold of high mechanical strength and having high reactivity with biomaterials such as collagen, respectively. The porous structure was observed through surface images, and its intrusion volume and porosity were measured. Owing to the carboxylic acids on PEAA, collagen was successfully grafted onto the porous HDPE/PEAA scaffold, which was confirmed by FT-IR spectroscopy and electron spectroscopy for chemical analysis. Osteoblasts were cultured on the collagen-grafted porous scaffold, and their adhesion, proliferation, and differentiation were investigated. The high viability and growth of the osteoblasts suggest that the collagen-grafted porous HDPE/PEAA is a promising scaffold material for bone generation.

Keywords

Acknowledgement

Supported by : Kyungpook National University

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