Biomaterials Research (생체재료학회지)

Korean Society for Biomaterials (한국생체재료학회)
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Electrophoretically prepared hybrid materials for biopolymer hydrogel and layered ceramic nanoparticles

  • Gwak, Gyeong-Hyeon (Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University) ;
  • Choi, Ae-Jin (Postharvest Research Team, National Institute of Horticultural and Herbal Science (NIHHS) of RDA) ;
  • Bae, Yeoung-Seuk (Postharvest Research Team, National Institute of Horticultural and Herbal Science (NIHHS) of RDA) ;
  • Choi, Hyun-Jin (Postharvest Research Team, National Institute of Horticultural and Herbal Science (NIHHS) of RDA) ;
  • Oh, Jae-Min (Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University)
  • Received : 2015.09.09
  • Accepted : 2016.01.04
  • Published : 2016.03.01
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Abstract

Background: In order to obtain biomaterials with controllable physicochemical properties, hybrid biomaterials composed of biocompatible biopolymers and ceramic nanoparticles have attracted interests. In this study, we prepared biopolymer/ceramic hybrids consisting of various natural biopolymers and layered double hydroxide (LDH) ceramic nanoparticles via an electrophoretic method. We studied the structures and controlled-release properties of these materials. Results and discussion: X-ray diffraction (XRD) patterns and X-ray absorption spectra (XAS) showed that LDH nanoparticles were formed in a biopolymer hydrogel through electrophoretic reaction. Scanning electron microscopic (SEM) images showed that the ceramic nanoparticles were homogeneously distributed throughout the hydrogel matrix. An antioxidant agent (i.e., ferulic acid) was loaded onto agarose/LDH and gelatin/LDH hybrids, and the time-dependent release of ferulic acid was investigated via high-performance liquid chromatography (HPLC) for kinetic model fitting. Conclusions: Biopolymer/LDH hybrid materials that were prepared by electrophoretic method created a homogeneous composite of two components and possessed controllable drug release properties according to the type of biopolymer.

Keywords

Acknowledgement

Supported by : RDA

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