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The Incidence of Malignant Tumors in Environmentally Disadvantaged Regions of Kazakhstan

  • Mamyrbayev, Arstan (West Kazakhstan branch of "National Centre for Occupational Health and Occupational Diseases") ;
  • Djarkenov, Timur (West Kazakhstan State Medical University named after Marat Ospanov) ;
  • Dosbayev, Askar (West Kazakhstan State Medical University named after Marat Ospanov) ;
  • Dusembayeva, Nailya (The Ecological Epidemiology Laboratory, National Centre for Occupational Health and Occupational Diseases MHSD) ;
  • Shpakov, Anatolyi (The Ecological Epidemiology Laboratory, National Centre for Occupational Health and Occupational Diseases MHSD) ;
  • Umarova, Gulmira (West Kazakhstan State Medical University named after Marat Ospanov) ;
  • Drobchenko, Yelena (The Ecological Epidemiology Laboratory, National Centre for Occupational Health and Occupational Diseases MHSD) ;
  • Kunurkulzhayev, Temirgali (West Kazakhstan State Medical University named after Marat Ospanov) ;
  • Zhaylybaev, Mukhtar (West Kazakhstan State Medical University named after Marat Ospanov) ;
  • Isayeva, Gulnar (West Kazakhstan State Medical University named after Marat Ospanov)
  • 발행 : 2016.12.01

초록

Objective: To explore the prevalence of malignant tumors in the adult population through 2003-2014 in parts of the Aral Sea region: a zone of ecological disaster, a zone of ecological crisis and a zone of precritical conditions. Methods: The long-time average annual levels of cancer morbidity stratified by zones of the Aral Sea region and trends of long-time average annual incidence indicators of malignant tumors were identified. Leading cancer localizations in the adult population was established and associations between cancer incidence and environmental pollution were analyzed. In addition, associations between individual risk factors and cancer incidence in the adult population was established. Correlations between a hazard index and the cancer incidence in the adult population were calculated. Results: In all three Aral Sea regions, as well as in Zhanaarkinskii district, leading cancer in adult population was esophageal, stomach, tracheal, lung, hepatobiliary, and breast. Long-time average annual levels of cancer morbidity in adult population living in the Aral sea region is 1.5 times higher comparing to the control region. In particular, long-time average annual levels of cancer morbidity in adult population living in the zone of ecological disaster was 57.2% higher, in the zone of ecological crisis - 61.9% higher, and in the zone of precritical condition - 16.8% higher. Long-time average annual levels in the adult population of the Aral Sea region significantly exceeded control levels for brain and central nervous system cancer, cancer of bone and articular cartilage, and thyroid cancer. Conclusion: It has was established that the total cancer morbidity depended on the total hazard index associated with the inhalation of nickel and the combined cadmium intake (r=0.8).

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참고문헌

  1. Aykan N, Yalcin S, Turhal N, et al (2015). Epidemiology of colorectal cancer in Turkey: A cross-sectional disease registry study (A Turkish Oncology Group trial). Turk J Gastroenterol, 26, 145-53. https://doi.org/10.5152/tjg.2015.5685
  2. Bekmukhambetov Y, Imangazina Z, Jarkenov T, et al (2015). Cancer incidence and mortality data in Aktobe, West Kazakhstan. 2000-2010. Asian Pac J Cancer Prev, 16, 2379-83. https://doi.org/10.7314/APJCP.2015.16.6.2379
  3. Bekmukhambetov Y, Mamyrbayev A, Jarkenov T, et al (2015). Malignant neoplasm prevalence in the Aktobe region of Kazakhstan. Asian Pac J Cancer Prev, 16, 8149-53.
  4. Cambra K, Martinez-Rueda T, Alonso-Fustel E, et al (2011). Mortality in small geographical areas and proximity to air polluting industries in the Basque Country (Spain). Occup Environ Med, 68, 140-7. https://doi.org/10.1136/oem.2009.048215
  5. Crouse D, Goldberg M, Ross N, et al (2010). Postmenopausal breast cancer is associated with exposure to traffic-related air pollution in Montreal, Canada: a case-control study. Environ Health Respect, 8, 1578-83
  6. Demetriou CA, Raaschou-Nielsen O, Loft S, et al (2012). Biomarkers of ambient air pollution and lung cancer: a systematic review. Occup Environ Med, 69, 619-27. https://doi.org/10.1136/oemed-2011-100566
  7. Ibeanu OA, Diaz-Montes TP (2013). Outcomes in ovarian cancer among hispanic women living in the United States: A population-based analysis. Patholog Res Int, 121, 1226-34.
  8. Igissinov N, Igissinov S, Moore MA, et al (2011). Trends of prevalent cancer incidences in the Aral-Syr Darya ecological area of Kazakhstan. Asian Pac J Cancer Prev, 12, 2299-303.
  9. Igissinov N, Tereshkevich D, Moore MA, et al (2011). Age characteristics of incidences of prevalent cancers in the Aral Sea area of Kazakhstan. Asian Pac J Cancer Prev, 12, 2295-7.
  10. Johannson KA, Balmes JR, Collard HR (2015). Air pollution exposure: a novel environmental risk factor for interstitial lung disease?. Chest, 147, 1161-7. https://doi.org/10.1378/chest.14-1299
  11. Kunzli N, Kutlar M (2013). Air pollution and health - counselling options for physicians. Ther Umsch, 70, 725-32. https://doi.org/10.1024/0040-5930/a000471
  12. Kutikhin A, Yuzhalin A, Brailovskiy V, et al (2012). Analysis of cancer incidence and mortality in the industrial region of South-East Siberia from 1991 through 2010. Asian Pac J Cancer Prev, 13, 5189-93. https://doi.org/10.7314/APJCP.2012.13.10.5189
  13. Laumbach RJ, Kipen HM (2012). Respiratory health effects of air pollution: update on biomass smoke and traffic pollution. J Allergy Clin Immunol, 129, 3-11. https://doi.org/10.1016/j.jaci.2011.11.021
  14. Magomedov OM (2011). Five-year survival of breast cancer patients in the Republic of Daghestan. Vopr Onkol, 56, 398-400.
  15. Mamyrbaev AA, Dzharkenov TA, Imangazina ZA, et al (2015). Mutagenic and carcinogenic actions of chromium and its compounds. Environ Health Prev Med, 20, 159-67. https://doi.org/10.1007/s12199-015-0458-2
  16. Mamyrbaev A, Umarova G (2016). Modern issues of public health: the review. Georgian Med News, 254, 61-7.
  17. Meek ME, Boobis AR, Crofton KM, et al (2011). Risk assessment of combined exposure to multiple chemicals. Geneva: A WHO/IPCS framework, Regulatory Toxicology and Pharmacology. Regul Toxicol Pharmacol, 14, 80-6.
  18. Moore MA, Aitmurzaeva G, Arsykulov ZA, et al (2009). Chronic disease prevention research in central asia, the Urals Siberia and Mongolia - past, present and future. Asian Pac J Cancer Prev, 10, 987-96.
  19. Moore MA, Eser S, Igisinov N, et al (2010). Cancer epidemiology and control in north-western and central asia - past, present and future. Asian Pac J Cancer Prev, 11, 17-32.
  20. Omirbaeva S, Kulkyibaev G (2004). Ekologicheski obuslovlennyie patologii (analiticheskiy obzor). Karagandinskiy TsINTI. Karaganda, 20, 1-18.
  21. Poirier M (2012). Chemical-induced DNA damage and human cancer risk. Discov Med, 14, 283-88.
  22. Sakiev K, Mamyrbayev A (2016). Sostoyanie zdorovya naseleniya odnogo iz neftegazodobyivayuschih regionov Kazahstana. Hygiene & Sanitation (Russian Journal), 95, 528-33.
  23. Slazhneva T, Popova T (2007). Ispolzovanie indeksa DALY v otsenke mediko-demograficheskoy situatsii v Respublike Kazahstan. BMC Health Serv Res, 6, 70-2.