DOI QR코드

DOI QR Code

Primary Pulmonary Amyloidosis with Mediastinal Lymphadenopathy

  • Kim, Dohun (Department of Thoracic and Cardiovascular Surgery, Chungbuk National University College of Medicine) ;
  • Lee, Yong-Moon (Department of Pathology, Chungbuk National University College of Medicine) ;
  • Kim, Si-Wook (Department of Thoracic and Cardiovascular Surgery, Chungbuk National University College of Medicine) ;
  • Kim, Jong-Won (Department of Thoracic and Cardiovascular Surgery, Chungbuk National University College of Medicine) ;
  • Hong, Jong-Myeon (Department of Thoracic and Cardiovascular Surgery, Chungbuk National University College of Medicine)
  • Received : 2015.07.24
  • Accepted : 2015.08.25
  • Published : 2016.06.05

Abstract

We report a case of inadvertent hoarseness after surgery for primary pulmonary amyloidosis. A 55-year-old male was transferred to our facility due to a lung mass. Chest computed tomography revealed a solitary pulmonary nodule. Positron emission tomography-computed tomography showed fluorodeoxyglucose uptake in the main mass and in the mediastinal lymph nodes. To confirm the pathology of the mass, wedge resection and thorough lymph node dissection were performed via video-assisted thoracic surgery (VATS). No complications except for hoarseness were observed; hoarseness developed soon after surgery and lasted for 3 months. The main mass was diagnosed as amyloidosis, but this was not found in the lymph nodes. In conclusion, VATS wedge resection for peripheral amyloidosis is a feasible and safe procedure. However, mediastinal lymph node dissection is not recommended unless there is evidence of a clear benefit.

Keywords

References

  1. Dong MJ, Zhao K, Liu ZF, Wang GL, Yang J. Primary pulmonary amyloidosis misdiagnosed as malignancy on dual-time-point fluoro-deoxyglucose positron emission tomography/computed tomography: a case report and review of the literature. Oncol Lett 2015;9:591-4. https://doi.org/10.3892/ol.2014.2778
  2. Eguchi T, Yoshida K, Kobayashi N, et al. Localized nodular amyloidosis of the lung. Gen Thorac Cardiovasc Surg 2011; 59:715-7. https://doi.org/10.1007/s11748-010-0748-y
  3. Jeon DH, Lee CS, Cho SR, Kim YO. Pulmonarg nodular amyloidosis. Korean J Thorac Cardiovasc Surg 1999;32: 1060-3.
  4. Utz JP, Swensen SJ, Gertz MA. Pulmonary amyloidosis: the Mayo Clinic experience from 1980 to 1993. Ann Intern Med 1996;124:407-13. https://doi.org/10.7326/0003-4819-124-4-199602150-00004
  5. Cordier JF. Pulmonary amyloidosis in hematological disorders. Semin Respir Crit Care Med 2005;26:502-13. https://doi.org/10.1055/s-2005-922033
  6. Yong HS, Woo OH, Lee JW, Suh SI, Oh YW, Kang EY. Primary localized amyloidosis manifested as supraclavicular and mediastinal lymphadenopathy. Br J Radiol 2007;80: e131-3. https://doi.org/10.1259/bjr/52539691
  7. Seo JH, Lee SW, Ahn BC, Lee J. Pulmonary amyloidosis mimicking multiple metastatic lesions on F-18 FDG PET/CT. Lung Cancer 2010;67:376-9. https://doi.org/10.1016/j.lungcan.2009.11.014
  8. Takeshita K, Yamada S, Sato N, et al. An unusual case of mediastinal lymphadenopathy caused by amyloidosis. Intern Med 2000;39:839-42. https://doi.org/10.2169/internalmedicine.39.839

Cited by

  1. Chapter 6 Non-Squamous Cell Causes of Cervical Lymphadenopathy vol.38, pp.5, 2016, https://doi.org/10.1053/j.sult.2017.05.006