Investigative Magnetic Resonance Imaging

Korean Society of Magnetic Resonance in Medicine (대한자기공명의과학회)
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Non-Invasive in vivo Loss Tangent Imaging: Thermal Sensitivity Estimation at the Larmor Frequency

  • Choi, Narae (Department of Electrical and Electronic Engineering, Yonsei University) ;
  • Kim, Min-Oh (Department of Electrical and Electronic Engineering, Yonsei University) ;
  • Shin, Jaewook (Department of Electrical and Electronic Engineering, Yonsei University) ;
  • Lee, Joonsung (Center for Neuroscience Imaging Research, Institute for Basic Science, Sungkyunkwan University) ;
  • Kim, Dong-Hyun (Department of Electrical and Electronic Engineering, Yonsei University)
  • Received : 2016.03.11
  • Accepted : 2016.03.20
  • Published : 2016.03.30
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Abstract

Visualization of the tissue loss tangent property can provide distinct contrast and offer new information related to tissue electrical properties. A method for non-invasive imaging of the electrical loss tangent of tissue using magnetic resonance imaging (MRI) was demonstrated, and the effect of loss tangent was observed through simulations assuming a hyperthermia procedure. For measurement of tissue loss tangent, radiofrequency field maps ($B_1{^+}$ complex map) were acquired using a double-angle actual flip angle imaging MRI sequence. The conductivity and permittivity were estimated from the complex valued $B_1{^+}$ map using Helmholtz equations. Phantom and ex-vivo experiments were then performed. Electromagnetic simulations of hyperthermia were carried out for observation of temperature elevation with respect to loss tangent. Non-invasive imaging of tissue loss tangent via complex valued $B_1{^+}$ mapping using MRI was successfully conducted. Simulation results indicated that loss tangent is a dominant factor in temperature elevation in the high frequency range during hyperthermia. Knowledge of the tissue loss tangent value can be a useful marker for thermotherapy applications.

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References

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