The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Glomerular filtration rate affects interpretation of pulmonary function test in a Korean general population: results from the Korea National Health and Nutrition Examination Survey 2010 to 2012

  • Kim, Young Soo (Epidemiology Study Cluster, College of Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea) ;
  • Kim, Hee Yeon (Epidemiology Study Cluster, College of Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea) ;
  • Ahn, Hyo-Suk (Epidemiology Study Cluster, College of Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea) ;
  • Sohn, Tae Seo (Epidemiology Study Cluster, College of Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea) ;
  • Song, Jae Yen (Epidemiology Study Cluster, College of Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea) ;
  • Lee, Young Bok (Epidemiology Study Cluster, College of Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea) ;
  • Lee, Dong-Hee (Epidemiology Study Cluster, College of Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea) ;
  • Lee, Jae-Im (Epidemiology Study Cluster, College of Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea) ;
  • Lee, Tae-Kyu (Epidemiology Study Cluster, College of Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea) ;
  • Jeong, Seong Cheol (Epidemiology Study Cluster, College of Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea) ;
  • Hong, Mihee (Epidemiology Study Cluster, College of Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea) ;
  • Chae, Hiun Suk (Epidemiology Study Cluster, College of Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea) ;
  • Han, Kyungdo (Department of Biostatistics, College of Medicine, The Catholic University of Korea) ;
  • Yeo, Chang Dong (Epidemiology Study Cluster, College of Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea)
  • Received : 2015.05.27
  • Accepted : 2015.07.06
  • Published : 2016.11.01
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Abstract

Background/Aims: The pulmonary abnormalities (principally restrictive abnormalities) are characteristic of renal transplant recipients or those with end-stage renal disease. Our aim was to explore whether the prevalence of spirometric abnormalities was influenced by the estimated glomerular filtration rates (GFRs) in a Korean general population. Methods: We used data obtained during the 2010 to 2012 Korean National Health and Nutrition Examination Survey, a national cross-sectional survey. We analyzed data from subjects for whom spirometric assays and estimated GFRs were of acceptable quality. Results: A total of 8,809 subjects (3,868 male and 4,941 female) was included. In both males and females with GFR values < $60mL/min/1.73m^2$, the linear trends toward the presence of obstructive and restrictive patterns were significant. However, the percent predicted forced vital capacity (FVC) decreased with a decline in the estimated GFR, but only in males (p for trend < 0.0031). Multivariate linear regression analysis showed a decline in the estimated GFR was independently associated with falls in the percent predicted FVC and the forced expiratory volume in 1 second/FVC ratio in both males and females. However, the percent predicted FVC was independently predictive only in males (p = 0.002). Conclusions: Impaired pulmonary function was associated with a decline in the estimated GFR. The percent predicted FVC decrease paralleled the decline in estimated GFR in male only. Careful interpretation of pulmonary function test data is required in patients with decreased GFRs or impaired renal function, especially males.

Keywords

References

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