The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Periodontitis is associated with rheumatoid arthritis: a study with longstanding rheumatoid arthritis patients in Korea

  • Choi, In Ah (Department of Internal Medicine, Medical Research Center, Seoul National University College of Medicine) ;
  • Kim, Jin-Hee (Department of Periodontology, Seoul National University School of Dentistry) ;
  • Kim, Yong Mi (Department of Periodontology, Seoul National University School of Dentistry) ;
  • Lee, Joo Youn (Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University) ;
  • Kim, Kyung Hwa (Department of Periodontology, Seoul National University School of Dentistry) ;
  • Lee, Eun Young (Department of Internal Medicine, Medical Research Center, Seoul National University College of Medicine) ;
  • Lee, Eun Bong (Department of Internal Medicine, Medical Research Center, Seoul National University College of Medicine) ;
  • Lee, Yong-Moo (Department of Periodontology, Seoul National University School of Dentistry) ;
  • Song, Yeong Wook (Department of Internal Medicine, Medical Research Center, Seoul National University College of Medicine)
  • Received : 2015.07.03
  • Accepted : 2015.09.02
  • Published : 2016.09.01
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Abstract

Background/Aims: A cross-sectional study was undertaken to investigate the association between severity of periodontitis and clinical manifestation of rheumatoid arthritis (RA). Methods: Two hundred sixty-four RA patients and 88 age- and sex-matched controls underwent dental exam. Additionally, clinical manifestations including disease activity and anti-citrullinated protein antibodies were evaluated in RA patients. Results: The prevalence of moderate or severe periodontitis was higher in RA patients compared to controls (63.6% vs 34.1%, p < 0.001). In markers of periodontal inflammation, bleeding on probing was correlated with disease activity score 28 (r = 0.128, p = 0.041), RA disease duration (r = 0.211, p = 0.001), erythrocyte sedimentation rate (ESR; r = 0.141, p = 0.023), anti-cyclic citrullinated peptide antibody (r = 0.183, p = 0.009), and anti-citrullinated ${\alpha}$-enolase peptide-1 antibody (r = 0.143, p = 0.025). Gingival index was correlated with RA duration (r = 0.262, p < 0.001), ESR (r = 0.162, p = 0.009), anti-cyclic citrullinated peptide antibody (r = 0.203, p = 0.004) and anti-citrullinated ${\alpha}$-enolase peptide-1 antibody (r = 0.225, p < 0.001). Periodontal structural damage represented by probing pocket depth and clinical attachment level were less in RA patients with human leukocyte antigen (HLA)-DRB1 shared epitope compared than those without shared epitope (p = 0.005 and p =0.006, respectively). Conclusions: The prevalence of moderate or severe periodontitis was increased in RA patients compared to controls. Periodontal inflammation was correlated with RA disease duration, ESR, and anti-citrullinated protein antibodies. Periodontal structural damage was less in RA patients with HLA-DRB1 shared epitope.

Keywords

Acknowledgement

Supported by : Ministry of Science, ICT and Future Planning

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