The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Incidence and risk factors of hepatitis C virus infection among human immunodeficiency virus (HIV) patients in a large HIV clinic in South Korea

  • Lee, Shinwon (Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital) ;
  • Lee, Sun Hee (Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital) ;
  • Lee, Su Jin (Department of Internal Medicine, Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital) ;
  • Kim, Kye-Hyung (Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital) ;
  • Lee, Jeong Eun (Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital) ;
  • Cho, Heerim (Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital) ;
  • Lee, Seung Geun (Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital) ;
  • Chung, Joo Seop (Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital) ;
  • Kwak, Ihm Soo (Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital)
  • Received : 2015.10.20
  • Accepted : 2016.01.02
  • Published : 2016.07.01
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Abstract

Background/Aims: Increasing incidences of hepatitis C virus (HCV) infection in human immunodeficiency virus (HIV)-infected men who have sex were reported in the United States and Europe. However, few studies regarding the epidemiology of HCV infection in HIV-infected patients in Asian countries have been reported. Methods: To determine the prevalence and incidence of HCV infection in HIV-infected patients, a retrospective cohort study was conducted. All HIV-infected patients who visited a tertiary care hospital in Korea from 2000 to 2013 were identified. Patients with ${\geq}1HCV$ antibody (Ab) test were included and observed until December 2014. Results: Among 996 HIV-infected patients, 790 patients (79%) had baseline HCV Ab tests and 41 (5.2%) were positive at baseline and four at follow-up. Experience of injecting drug use (IDU; adjusted odds ratio, 16.20; 95% confidence interval [CI], 1.56 to 167.89; p < 0.01) was significantly associated with prevalent HCV infection. Conversion to HCV Ab positivity was observed in four of 384 included patients, with an incidence rate of 2.22 (95% CI, 0.60 to 5.80)/1,000 person-years (PYs); 164.89 (95% CI, 34.00 to 481.88)/1,000 PYs in patients with IDU, and 1.40 (95% CI, 0.35 to 7.79)/1,000 PYs in men who have sex with men who denied IDU. There was no significant increase in incidence rate of HCV in HIV-infected patients from 2009 to 2014 (p = 0.119). Among 19 patients who were positive for HCV RNA, genotype 1b (73%) was the most common following 2a/2c (20%). Conclusions: IDU was an independent risk factor for prevalent HCV infection. Prevalence of HCV infection was low and incidence of HCV infection was not significantly increased in HIV-infected patients in South Korea.

Keywords

Acknowledgement

Supported by : Pusan National University Hospital

References

  1. Fierer DS, Dieterich DT, Fiel MI, et al. Rapid progression to decompensated cirrhosis, liver transplant, and death in HIV-infected men after primary hepatitis C virus infection. Clin Infect Dis 2013;56:1038-1043. https://doi.org/10.1093/cid/cis1206
  2. Sulkowski MS, Thomas DL. Hepatitis C in the HIV-infected person. Ann Intern Med 2003;138:197-207. https://doi.org/10.7326/0003-4819-138-3-200302040-00012
  3. Berenguer J, Alvarez-Pellicer J, Martin PM, et al. Sustained virological response to interferon plus ribavirin reduces liver-related complications and mortality in patients coinfected with human immunodeficiency virus and hepatitis C virus. Hepatology 2009;50:407-413. https://doi.org/10.1002/hep.23020
  4. The U.S. Department of Health and Human Services (DHHS). Guidelines for the Use of Antiretrovial Agents in HIV-1-infected Adults and Adolescents [Internet]. Rockville (MD): AIDSinfo, 2014 [cited 2016 Mar 30]. Available from: https://aidsinfo.nih.gov/guidelines.
  5. Bani-Sadr F, Barange K, Daoud F, et al. Persistently normal alanine aminotransferase levels in HIV/HCV-coinfected patients: the role of steatosis. HIV Med 2009;10:417-421. https://doi.org/10.1111/j.1468-1293.2009.00702.x
  6. Kao JH, Liu CJ, Chen PJ, Chen W, Lai MY, Chen DS. Low incidence of hepatitis C virus transmission between spouses: a prospective study. J Gastroenterol Hepatol 2000;15:391-395. https://doi.org/10.1046/j.1440-1746.2000.02165.x
  7. Murphy EL, Bryzman SM, Glynn SA, et al. Risk factors for hepatitis C virus infection in United States blood donors. NHLBI Retrovirus Epidemiology Donor Study (REDS). Hepatology 2000;31:756-762. https://doi.org/10.1002/hep.510310329
  8. Rauch A, Rickenbach M, Weber R, et al. Unsafe sex and increased incidence of hepatitis C virus infection among HIV-infected men who have sex with men: the Swiss HIV Cohort Study. Clin Infect Dis 2005;41:395-402. https://doi.org/10.1086/431486
  9. Vandelli C, Renzo F, Romano L, et al. Lack of evidence of sexual transmission of hepatitis C among monogamous couples: results of a 10-year prospective follow-up study. Am J Gastroenterol 2004;99:855-859. https://doi.org/10.1111/j.1572-0241.2004.04150.x
  10. Soto B, Rodrigo L, Garcia-Bengoechea M, et al. Heterosexual transmission of hepatitis C virus and the possible role of coexistent human immunodeficiency virus infection in the index case: a multicentre study of 423 pairings. J Intern Med 1994;236:515-519. https://doi.org/10.1111/j.1365-2796.1994.tb00838.x
  11. Browne R, Asboe D, Gilleece Y, et al. Increased numbers of acute hepatitis C infections in HIV positive homosexual men: is sexual transmission feeding the increase? Sex Transm Infect 2004;80:326-327. https://doi.org/10.1136/sti.2003.008532
  12. Danta M, Brown D, Bhagani S, et al. Recent epidemic of acute hepatitis C virus in HIV-positive men who have sex with men linked to high-risk sexual behaviours. AIDS 2007;21:983-991. https://doi.org/10.1097/QAD.0b013e3281053a0c
  13. Taylor LE, Holubar M, Wu K, et al. Incident hepatitis C virus infection among US HIV-infected men enrolled in clinical trials. Clin Infect Dis 2011;52:812-818. https://doi.org/10.1093/cid/ciq201
  14. van de Laar TJ, van der Bij AK, Prins M, et al. Increase in HCV incidence among men who have sex with men in Amsterdam most likely caused by sexual transmission. J Infect Dis 2007;196:230-238. https://doi.org/10.1086/518796
  15. European AIDS Clinical Society. European guidelines for treatment of HIV infected adults version 7.1 [Internet]. Brussels (BE): European AIDS Clinical Society, c2016 [cited 2016 Mar 30]. Available from: http://www.eacsociety.org.
  16. Nishijima T, Shimbo T, Komatsu H, Hamada Y, Gatanaga H, Oka S. Incidence and risk factors for incident hepatitis C infection among men who have sex with men with HIV-1 infection in a large urban HIV clinic in Tokyo. J Acquir Immune Defic Syndr 2014;65:213-217. https://doi.org/10.1097/QAI.0000000000000044
  17. Sun HY, Chang SY, Yang ZY, et al. Recent hepatitis C virus infections in HIV-infected patients in Taiwan: incidence and risk factors. J Clin Microbiol 2012;50:781-787. https://doi.org/10.1128/JCM.06014-11
  18. 1993 Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR Recomm Rep 1992;41(RR-17):1-19.
  19. Garg S, Taylor LE, Grasso C, Mayer KH. Prevalent and incident hepatitis C virus infection among HIV-infected men who have sex with men engaged in primary care in a Boston Community Health Center. Clin Infect Dis 2013;56:1480-1487. https://doi.org/10.1093/cid/cit054
  20. Giraudon I, Ruf M, Maguire H, et al. Increase in diagnosed newly acquired hepatitis C in HIV-positive men who have sex with men across London and Brighton, 2002-2006: is this an outbreak? Sex Transm Infect 2008;84:111-115. https://doi.org/10.1136/sti.2007.027334
  21. Linas BP, Wong AY, Schackman BR, Kim AY, Freedberg KA. Cost-effective screening for acute hepatitis C virus infection in HIV-infected men who have sex with men. Clin Infect Dis 2012;55:279-290. https://doi.org/10.1093/cid/cis382
  22. Kim do Y, Kim IH, Jeong SH, et al. A nationwide seroepidemiology of hepatitis C virus infection in South Korea. Liver Int 2013;33:586-594. https://doi.org/10.1111/liv.12108
  23. Oh DJ, Park YM, Seo YI, Lee JS, Lee JY. Prevalence of hepatitis C virus infections and distribution of hepatitis C virus genotypes among Korean blood donors. Ann Lab Med 2012;32:210-215. https://doi.org/10.3343/alm.2012.32.3.210
  24. Park SH, Park CK, Lee JW, et al. Efficacy and tolerability of peginterferon alpha plus ribavirin in the routine daily treatment of chronic hepatitis C patients in Korea: a multi-center, retrospective observational study. Gut Liver 2012;6:98-106. https://doi.org/10.5009/gnl.2012.6.1.98
  25. Afdhal NH, McHutchison JG, Zeuzem S, et al. Hepatitis C pharmacogenetics: state of the art in 2010. Hepatology 2011;53:336-345. https://doi.org/10.1002/hep.24052
  26. Sulkowski MS. HCV therapy in HIV-infected patients. Liver Int 2013;33 Suppl 1:63-67. https://doi.org/10.1111/liv.12082
  27. Jeong SH, Jung YK, Yang JW, et al. Efficacy of peginterferon and ribavirin is associated with the IL28B gene in Korean patients with chronic hepatitis C. Clin Mol Hepatol 2012;18:360-367. https://doi.org/10.3350/cmh.2012.18.4.360
  28. Jung YK, Kim JH, Ahn SM, et al. Role of interleukin 28B-related gene polymorphisms in chronic hepatitis C and the response to antiviral therapy in Koreans. J Clin Gastroenterol 2013;47:644-650. https://doi.org/10.1097/MCG.0b013e3182896abf
  29. Kil H, Jeong SH, Kim JW, et al. Role of interleukin-28B genetic polymorphisms in Korean patients with hepatitis C virus infection. Gut Liver 2014;8:70-78. https://doi.org/10.5009/gnl.2014.8.1.70
  30. Sulkowski MS, Sherman KE, Dieterich DT, et al. Combination therapy with telaprevir for chronic hepatitis C virus genotype 1 infection in patients with HIV: a randomized trial. Ann Intern Med 2013;159:86-96.
  31. Sulkowski M, Pol S, Mallolas J, et al. Boceprevir versus placebo with pegylated interferon alfa-2b and ribavirin for treatment of hepatitis C virus genotype 1 in patients with HIV: a randomised, double-blind, controlled phase 2 trial. Lancet Infect Dis 2013;13:597-605. https://doi.org/10.1016/S1473-3099(13)70149-X
  32. Holmes JA, Thompson AJ. Interferon-free combination therapies for the treatment of hepatitis C: current insights. Hepat Med 2015;7:51-70.
  33. Korean Centers for Disease Control and Prevention. Annual report on the notified HIV/AIDS in Korea 2014 [Internet]. Cheongju (KR): Korean Centers for Disease Control and Prevention, 2014 [cited 2016 Mar 30]. Available from: http://nih.go.kr/NIH_NEW/main.jsp.
  34. Korean Centers for Disease Control and Prevention. Annual report on the notified HIV/AIDS in Korea 2010 [Internet]. Cheongju (KR): Korean Centers for Disease Control and Prevention, 2010 [cited 2016 Mar 30]. Available from: http://nih.go.kr/NIH_NEW/main.jsp.

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