The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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A prospective cohort study of latent tuberculosis in adult close contacts of active pulmonary tuberculosis patients in Korea

  • Park, Sun Hyo (Department of Internal Medicine, Dongnam Institute of Radiological & Medical Sciences Cancer Center) ;
  • Lee, Seung Jun (Department of Internal Medicine, Gyeongsang National University School of Medicine) ;
  • Cho, Yu Ji (Department of Internal Medicine, Gyeongsang National University School of Medicine) ;
  • Jeong, Yi Yeong (Department of Internal Medicine, Gyeongsang National University School of Medicine) ;
  • Kim, Ho Cheol (Department of Internal Medicine, Gyeongsang National University School of Medicine) ;
  • Lee, Jong Deog (Department of Internal Medicine, Gyeongsang National University School of Medicine) ;
  • Kim, Hee Jin (Korean Institute of Tuberculosis) ;
  • Menzies, Dick (Montreal Chest Institute, McGill University)
  • Received : 2015.04.09
  • Accepted : 2015.06.15
  • Published : 2016.05.01
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Abstract

Background/Aims: The objective of this prospective study was to evaluate the diagnosis and treatment of latent tuberculosis infection (LTBI) in adult close contacts of active pulmonary tuberculosis (TB) patients in Korea. Methods: Adult close contacts of active pulmonary TB patients were recruited at a regional tertiary hospital in Korea. The participants were tested for LTBI using the tuberculin skin test (TST) and/or QuantiFERON-TB Gold (QFT-G) test. LTBI patients, who consented to treatment, were randomly assigned to receive isoniazid for 9 months (9INH) or rifampin for 4 months (4RIF). Results: We examined 189 adult close contacts (> 18 years) of 107 active pulmonary TB patients. The TST and QFT-G were positive (${\geq}10mm$) in 75/183 (39.7%) and 45/118 (38.1%) tested participants, respectively. Among 88 TST or QFT-G positive LTBI participants, 45 participants were randomly assigned to receive 4RIF (n = 21) or 9INH (n = 24), respectively. The average treatment duration for the 4RIF and 9INH groups was $3.3{\pm}1.3$ and $6.1{\pm}2.7months$, respectively. Treatment was completed in 25 participants (4RIF, n = 16; 9INH, n = 9). LTBI participants who accepted treatment were more likely to be women and have more cavitary lesions on the chest radiographs of index cases and positive TST and QFT-G results compared to those who refused treatment. Conclusions: About 40% of adult close contacts of active pulmonary TB patients had LTBI; about 50% of these LTBI participants agreed to treatment.

Keywords

Acknowledgement

Supported by : Canadian Institutes of Health Research

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