The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry

  • Park, So Young (Division of Pulmonary, Allergy and Critical Care Medicine, Hallym University Kangdong Sacred Heart Hospital and Lung Research Institute, Hallym University College of Medicine) ;
  • Lee, Sang Min (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine) ;
  • Shin, Jong Wook (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chung-Ang University College of Medicine) ;
  • Choi, Byoung Whui (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chung-Ang University College of Medicine) ;
  • Kim, Hojoong (Division of Pulmonary Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lee, Jae Seung (Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Sang Do (Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Park, Sung Soo (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Moon, Hwa Sik (Department of Internal Medicine, College of Medicine, St. Paul's Hospital, The Catholic University of Korea) ;
  • Park, Yong Bum (Division of Pulmonary, Allergy and Critical Care Medicine, Hallym University Kangdong Sacred Heart Hospital and Lung Research Institute, Hallym University College of Medicine)
  • Received : 2014.04.30
  • Accepted : 2015.04.28
  • Published : 2016.03.01
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Abstract

Background/Aims: The diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is difficult for numerous reasons and is related with a poor prognosis. In Korea, the incidence of CTEPH and its clinical features are unknown. Thus, in this study, we evaluated the clinical characteristics and outcomes of CTEPH in a Korean cohort. Methods: This study included South Korean patients diagnosed with CTEPH between September 2008 and October 2011. Baseline characteristics, treatments and outcomes were analyzed. Results: A total of 134 patients were included in this study with 76 females (56.7%). Their median age was $58.3{\pm}15.9years$ and dyspnea (112 patients, 83.5%) was the most common presenting symptom. Sixty-three patients (47%) had a history of acute pulmonary embolism or deep vein thrombosis, and six (4.5%) had pulmonary tuberculosis. In total, 28 patients (21%) underwent pulmonary thromboendarterectomy (PTE), and 99 patients had medical therapy. During the study period, 18 patients (13.4%) died. In a multivariate analysis, higher hemoglobin (relative risk [RR], 1.516; 95% confidence interval [CI], 1.053 to 2.184; p = 0.025) and lower total cholesterol levels (RR, 0.982; 95% CI, 0.965 to 0.999; p = 0.037) were associated with increased mortality. Conclusions: This was the first national cohort study of Korean patients with CTEPH. Accurate diagnosis, characterization and distributions of CTEPH are imperative for prompt treatment in patients, particularly those undergoing PTE.

Keywords

References

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