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Regulation of Th2 Cell Immunity by Dendritic Cells

  • Hyeongjin Na (Laboratory of Immune Regulation, Research Institute for Pharmaceutical Sciences, College of Pharmacy, Seoul National University) ;
  • Minkyoung Cho (Laboratory of Immune Regulation, Research Institute for Pharmaceutical Sciences, College of Pharmacy, Seoul National University) ;
  • Yeonseok Chung (Laboratory of Immune Regulation, Research Institute for Pharmaceutical Sciences, College of Pharmacy, Seoul National University)
  • Received : 2015.12.17
  • Accepted : 2016.01.26
  • Published : 2016.02.29
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Abstract

Th2 cell immunity is required for host defense against helminths, but it is detrimental in allergic diseases in humans. Unlike Th1 cell and Th17 cell subsets, the mechanism by which dendritic cells modulate Th2 cell responses has been obscure, in part because of the inability of dendritic cells to provide IL-4, which is indispensable for Th2 cell lineage commitment. In this regard, immune cells other than dendritic cells, such as basophils and innate lymphoid cells, have been suggested as Th2 cell inducers. More recently, multiple independent researchers have shown that specialized subsets of dendritic cells mediate Th2 cell responses. This review will discuss the current understanding related to the regulation of Th2 cell responses by dendritic cells and other immune cells.

Keywords

Acknowledgement

This work was supported by research grants SNU invitation for distinguished scholar (to YC) and 2014R1A2A1A11054364 (to YC), 2015R1D1A1A01059719 (to MC) from the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) and by Global Ph.D. Fellowship Program through the NRF funded by the Ministry of Education (2015H1A2A1030805) (to HN).

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