Journal of Cardiovascular Imaging

  • 제24권3호
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  • Pages.215-222
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  • 2016
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  • 2586-7210(pISSN)
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  • 2586-7296(eISSN)
한국심초음파학회 (Korean Society of Echocardiography)
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The Value of Elastic Modulus Index as a Novel Surrogate Marker for Cardiovascular Risk Stratification by Dimensional Speckle-Tracking Carotid Ultrasonography

  • Yoon, Ji Hyun (Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Cho, In-Jeong (Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Chang, Hyuk-Jae (Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Sung, Ji Min (Cardiovascular Research Institute, Yonsei University College of Medicine) ;
  • Lee, Jinyong (Infrastructure Technology Lab, Samsung Medison) ;
  • Ryoo, Hojin (Infrastructure Technology Lab, Samsung Medison) ;
  • Shim, Chi Young (Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Hong, Geu-Ru (Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Chung, Namsik (Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine)
  • 투고 : 2016.04.26
  • 심사 : 2016.07.26
  • 발행 : 2016.09.27
⟨ 이전 논문 다음 논문 ⟩

초록

Background: Carotid intima media thickness (CIMT) and the presence of carotid plaque have been used for risk stratification of cardiovascular disease (CVD). To date, however, the association between multi-directional functional properties of carotid artery and CVD has not been fully elucidated. We sought to explore the multi-directional mechanics of the carotid artery in relation to cardiovascular risk. Methods: Four hundred one patients who underwent carotid ultrasound were enrolled between January 2010 and April 2013. A high risk of CVD was defined as more than 20% of 10-year risk based on the Framingham risk score. Using a speckle-tracking technique, the longitudinal and radial movements were analyzed in the B-mode images. Peak longitudinal and radial displacements, strain and strain rate were also measured. Beta stiffness and elastic modulus index were calculated from the radial measurements. Results: Of the overall sample, 13% (52) of patients comprised the high-risk group. In multivariate logistic regression, CIMT and elastic modulus index were independently associated with a high-risk of CVD {odds ratio (OR): 1.810 [95% confidence interval (CI) 1.249-2.622] and OR: 1.767 (95% CI: 1.177-2.652); p = 0.002, 0.006, respectively}. The combination of CIMT and elastic modulus index correlated with a high-risk of CVD more so than CIMT alone. Conclusion: The elastic modulus index of the carotid artery might serve as a novel surrogate marker of high-risk CVD. Measurement of the multi-directional mechanics of the carotid artery using the speckle tracking technique has potential for providing further information over conventional B-mode ultrasound for stratification of CVD risk.

키워드

과제정보

연구 과제 주관 기관 : National Research Foundation of Korea (NRF)

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피인용 문헌

  1. Ultrasound assessment of tensile stress in carotid arteries of healthy human subjects with varying age vol.19, pp.1, 2019, https://doi.org/10.1186/s12880-019-0394-5